Search

The combination of JWST and ALMA data here unravel the history of the gas content of a quiescent galaxy, which became quenched through an act of self-sabotage. Black-hole accretion feedback heated the galaxy’s surrounding material, preventing its accretion.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

A recent study shows that neural symbolic regression offers a route to automated discovery of governing equations for network dynamics across high-dimensional complex systems.

Spatial dynamics can obscure epidemic trends from surveillance data, biasing reproduction ratio estimates over long periods. A spectral correction reweights incidence data to remove this bias, thus improving monitoring to inform response strategies.

In this Consensus Statement, an international panel of experts present an overview of the latest developments in the field of cholangiocarcinoma. A set of consensus recommendations and research priorities is provided.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Leukaemia development has been reported as an associated risk of haematopoietic stem cell gene therapy (HSPC-GT) using retroviral vectors in different diseases. Here, the authors show a case of T-cell acute lymphoid leukaemia in a patient with Adenosine Deaminase-deficient Severe Combined Immunodeficiency (ADA-SCID) treated with retroviral gene therapy.

Activity recognition in live-cell imaging is laborious. Here, authors present, IVEA, a fully automated AI ImageJ plugin, that efficiently detects and classifies exocytosis events, from synaptic transmission to single-vesicle fusion, across cell types and imaging setups.

Two-colour X-ray free electron laser is a powerful tool for pump–probe measurements, but currently constrained by limited tunability. Here, Ferrari et al. develop a configuration that allows tuning both the pump and the probe to specific electronic excitations, providing element selectivity.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Spatially resolved JWST spectroscopy of a massive, quiescent galaxy at a redshift of ~4 reveals that it formed its stars and quenched rapidly, despite being surrounded by an abundant gas reservoir and gravitationally bound to a star-bursting companion.

To celebrate the first 10 years ofNature Reviews Neuroscience, we invited the authors of the most cited article of each year to look back on the state of their field at the time of publication and the impact their article has had, and to discuss the questions that might be answered in the next 10 years.

We’re all familiar with the annoying problem of trying to peel sticky tape from a surface, only for the detached piece to narrow into a point and break off. Surprisingly, this phenomenon can be put to good use in deriving the mechanical parameters of a wide variety of thin, adhesive films.

Combined analysis of new genomic data from 116 ancient hunter-gatherer individuals together with previously published data provides insights into the genetic structure and demographic shifts of west Eurasian forager populations over a period of 30,000 years.

Anlló et al. show that context effects on reward value encoding are found across 11 diverse countries, suggesting that this may be a basic feature of human decision-making.

A long-lived photoinduced metastable state in a quasi-one-dimensional cuprate, Sr₁₄Cu₂₄O₄₁, is reported.

A new approach called liquid biopsy integration site sequencing enables monitoring of genetically modified cells in solid tissues of patients receiving gene therapy.

Strong near-infrared spectral features from asymptotic giant branch stars are detected by JWST in the integrated light from distant quiescent galaxies, clarifying their contribution to galaxy spectra and population synthesis models.

Earth surface continues to slip after large earthquakes at a slow velocity for a period of a year or more. In this study, the authors show how such slow slip before and after large earthquakes relates to the interaction of the brittle zone of the fault with the ductile zone at greater depth.

The authors report the photometric detection of the distant spectroscopically confirmed galaxy JADES-GS-z14-0 at z > 14 with JWST/MIRI. The inferred properties suggest rapid mass assembly and metal enrichment during the earliest phases of galaxy formation.

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

A dormant supermassive black hole at high redshift that is substantially overmassive relative to its host galaxy has been detected, indicating a much larger population of dormant black holes around the epoch of reionization.

Approaches for assessing epidemic risks meet challenges when dealing with high-resolution data available nowadays, that includes behaviors, disease progression, and interventions. The authors propose an analytical framework to compute the epidemic threshold for arbitrary models of diseases, interventions, and hosts contact patterns.

A massive galaxy hosting an accreting supermassive black hole two billion years after the Big Bang shows fast neutral-gas outflows that are capable of stopping star formation by removing its fuel while the stars keep rotating in a disk.

Pre-exposure prophylaxis (PrEP) is an effective HIV prevention measure but identifying those most at risk to target for treatment is challenging. Here, the authors demonstrate that non-selective PrEP distribution outperforms targeted strategies when use is not consistent, and/or prevalence of untreated HIV is high.

ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear. Here authors use structural and biophysical methods to show how human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation.

A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

In a randomized phase 3 trial, the combination of the BET inhibitor pelabresib with the JAK inhibitor ruxolitinib resulted in a significantly higher spleen volume reduction from baseline versus placebo with ruxolitinib in patients with JAK inhibitor-naive myelofibrosis.

This study on respiratory syncytial virus (RSV) reveals global genomic gaps. Using INFORM-RSV data, it uncovers selection’s impact on RSVA and RSVB diversity. Analysing full genomes, it highlights non-neutral epidemic processes. The research emphasises air travel’s influence on global spread, underscoring the need for comprehensive RSV genomic surveillance.

Human mobility influences the spatial distribution of infectious diseases such as HIV. Here, the authors use call data records from mobile phones to model HIV networks in Namibia and estimate that ~40% of the risk of HIV acquisition is driven by mobility.

An analysis of viral genomes and epidemiological data from the 2022 mpox outbreak in Portugal sheds light on the heterogeneity of early transmission events, with national and international linkages.

Spectroscopy from the JWST Advanced Deep Extragalactic Survey of a galaxy at redshift 13 shows a singular, bright emission line identified as Lyman-α, suggesting the onset of reionization only 330 Myr after the Big Bang.

Membrane contact sites (MCS) are subcellular regions where two organelles appose their membranes to exchange small molecules, including lipids. Here authors designed an in vitro MCS suitable for cryotomography and sub-tomogram analysis which sheds light on the recruitment of proteins of different sizes within MCS of adjustable thickness.

Extending quantum photonics’ capabilities from simple linear-optics-based schemes to universal quantum computing presents several challenges, but intermediate regimes with some degree of adaptivity might already bring practical advantages. Here, the authors experimentally emulate an adaptive Boson Sampling scheme using post-selection, and apply it to a data classification task.

Using hard X-rays for transient grating (TG) spectroscopy, fundamental excitations can be followed with femtosecond temporal and nanometer spatial resolution, selecting momenta, chemical elements and their chemical environment. The authors demonstrate the first experiment of all X-ray TG on an amorphous film of FeGd and on a silicon single crystal.

Analysis of the JWST/NIRSpec spectrum of the recently observed Lyman-break galaxy JADES-GS+53.15508-27.80178 revealed a redshift of z = 7.3, a Balmer break and a complete absence of nebular emission lines, indicating that quenching occurred only 700 million years after the Big Bang.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Evidence is found for a distant galaxy growing inside-out within the first 700 million years of the Universe. The galaxy has a dense central core comparable in mass density to local massive ellipticals, and an extended star-forming disc.

Experimental approaches that can directly measure spin-lattice coupling are rare. Here, authors report direct observation of the coupling of the phonon and magnon dynamics of a coherently driven electromagnon in a multiferroic hexaferrite using time-resolved X-ray diffraction. (277 characters in total).

Four mechanical waveforms at the nanoscale have been electrically generated by Fourier synthesis of a monochromatic surface acoustic wave and three of its harmonics.

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

JWST–NIRSpec spectroscopic confirmation of two luminous galaxies is presented, proving that luminous galaxies were already in place 300 million years after the Big Bang and are more common than what was expected before JWST.

Duchenne muscular dystrophy is characterised by progressive muscle weakness and variable brain involvement. In this review the authors describe the molecular underpinning of this brain involvement, and how genetic therapies improve behavioural outcomes in the dystrophic mouse models.

As part of the JWST Advanced Deep Extragalactic Survey (JADES), NIRSpec has spectroscopically confirmed four young and metal-poor galaxies at redshift 10.3–13.2, from an early epoch of galaxy formation.

The JWST Advanced Deep Extragalactic Survey using NIRCam to find the earliest galaxies reveals the size and star formation rates of four extreme redshift (z > 10) galaxies of the distant Universe.

Multiancestry genome-wide association analyses identify new risk loci for stroke and stroke subtypes. Fine mapping and bioinformatics analyses of these risk loci point to mechanisms not previously implicated in stroke pathophysiology.