Nature Search

Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
PLD3 variants in population studies

Sven J. van der Lee
Henne Holstege
Cornelia M. van Duijn
Research01 Apr 2015
Nature

Volume: 520, P: E2-E3
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

MicroRNAs (miRNAs) are involved in the regulation of gene expression and have been implicated in the pathology of several diseases. Here, van Rooij and Olson discuss the chemistry of current miRNA inhibitors and evaluate miRNAs as potential therapeutic targets for cardiovascular disorders.

Eva van Rooij
Eric N. Olson
Reviews19 Oct 2012
Nature Reviews Drug Discovery

Volume: 11, P: 860-872
Maintaining the LYVE1 line through macrophage and lymphatic interplay in the regenerating neonatal heart

The lymphatic vasculature has emerged as a key component of the heart’s response to injury, influencing both regeneration and maladaptive remodeling. Research now highlights the role of lymphatic clearance in shaping the composition of tissue-resident macrophages within the neonatal heart.

Tim Koopmans
Eva van Rooij
News & Views17 Sept 2025
Nature Cardiovascular Research

Volume: 4, P: 1211-1213
Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation

To regenerate the injured heart, cardiomyocytes must proliferate to replace lost myocardial tissue, but this capacity is largely absent in adult mammals. In this Review, Koopmans and van Rooij explore the key pathways that drive cardiomyocyte maturation after birth and how targeted manipulation might reactivate the cell cycle in adult cardiomyocytes.

Tim Koopmans
Eva van Rooij
Reviews07 Apr 2025
Nature Reviews Cardiology

Volume: 22, P: 857-882
The transcriptional landscape of age in human peripheral blood

Ageing increases the risk of many diseases. Here the authors compare blood cell transcriptomes of over 14,000 individuals and identify a set of about 1,500 genes that are differently expressed with age, shedding light on transcriptional programs linked to the ageing process and age-associated diseases.

Marjolein J. Peters
Roby Joehanes
Andrew D. Johnson
ResearchOpen Access22 Oct 2015
Nature Communications

Volume: 6, P: 1-14
Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Kyriakopoulou et al. report that adeno-associated virus-mediated delivery of PKP2 in PKP2^{c.2013delC/WT} induced pluripotent stem cell-derived cardiomyocytes and heterozygous Pkp2^c.1755delA knock-in mice restores cardiomyocyte junctions, enhances cardiac function and mitigates arrhythmogenic substrates leading to arrhythmogenic cardiomyopathy.

Eirini Kyriakopoulou
Danielle Versteeg
Eva van Rooij
ResearchOpen Access07 Dec 2023
Nature Cardiovascular Research

Volume: 2, P: 1262-1276
Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

Bouwman et al. identify Hmga1-mediated chromatin remodeling as the fundamental regulator of zebrafish cardiac regeneration and reveal the potential of Hmga1 to restore heart repair in mice by reactivating developmental genes, suggesting potential therapeutic applications.

Mara Bouwman
Dennis E. M. de Bakker
Jeroen Bakkers
ResearchOpen Access02 Jan 2025
Nature Cardiovascular Research

Volume: 4, P: 64-82
ChatGPT: five priorities for research

Conversational AI is a game-changer for science. Here’s how to respond.

Eva A. M. van Dis
Johan Bollen
Claudi L. Bockting
Comments & Opinion03 Feb 2023
Nature

Volume: 614, P: 224-226
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ischemia-driven heart failure.

Niels Grote Beverborg
Daniela Später
Peter van der Meer
ResearchOpen Access30 Aug 2021
Nature Communications

Volume: 12, P: 1-15
Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation

Cardiac regeneration is hindered by the limited division of cardiomyocytes. Here, the authors show that Arid1a drives maturation and limits proliferation through interaction with Yap. Suppression of Arid1a enhances proliferation after injury.

Cornelis J. Boogerd
Ilaria Perini
Eva van Rooij
ResearchOpen Access05 Aug 2023
Nature Communications

Volume: 14, P: 1-17
ATF3’s shielding hand to counter ischemia-reperfusion injury in cardiac macrophages

Pro-reparative cardiac-resident macrophages have emerged as major players in salvaging the ischemic myocardium of a diseased heart. New research now highlights ATF3 as a key transcription factor that governs macrophage survival and proliferation and myocardial repair.

Tim Koopmans
Alejandro Cardona-Monzonís
Eva van Rooij
News & Views04 Jan 2024
Nature Cardiovascular Research

Volume: 3, P: 15-17
Genome-wide association study identifies 48 common genetic variants associated with handedness

A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.

Gabriel Cuellar-Partida
Joyce Y. Tung
Sarah E. Medland
Research28 Sept 2020
Nature Human Behaviour

Volume: 5, P: 59-70
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

DNA methylation quantitative trait locus (mQTL) analyses on 32,851 participants identify genetic variants associated with DNA methylation at 420,509 sites in blood, resulting in a database of >270,000 independent mQTLs.

Josine L. Min
Gibran Hemani
Caroline L. Relton
Research06 Sept 2021
Nature Genetics

Volume: 53, P: 1311-1321
Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

ZEB2 transcription factor is increased in a subset of cardiomyocytes during stress to induce cardioprotective effects after injury. Here the authors show that therapeutic delivery of ZEB2 prevents cardiac dysfunction after ischemic damage and promotes the activation of pro-angiogenic signals.

Monika M. Gladka
Arwa Kohela
Eva van Rooij
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-16
CRISPR base editing lowers cholesterol in monkeys

Targeting a gene linked to cardiovascular disease shows therapeutic promise.

Sebastiaan Johannes van Kampen
Eva van Rooij
News & Views24 Jun 2021
Nature Biotechnology

Volume: 39, P: 920-921
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Living guidelines for generative AI — why scientists must oversee its use

Establish an independent scientific body to test and certify generative artificial intelligence, before the technology damages science and public trust.

Claudi L. Bockting
Eva A. M. van Dis
Johan Bollen
Comments & Opinion19 Oct 2023
Nature

Volume: 622, P: 693-696
Defining the pathways of heart regeneration

Although cardiac cell therapy has been intensely studied, the high expectations are still an unmet goal. A study now characterizes the translational potential and mode of action of human ventricular progenitors (HVPs) derived from embryonic stem cells, as a source for cardiac cell therapy.

Louk Theodoor Timmer
Eva van Rooij
News & Views12 May 2022
Nature Cell Biology

Volume: 24, P: 606-607
High-throughput methods to help understand heart disease

Recent developments in high-throughput, in-depth sequencing platforms are providing opportunities to improve our understanding of biology and disease. Here, Kuppe et al. use a combinatorial approach to relate transcriptional changes to translational and functional implications for the heart in response to myocardial infarction.

Martijn Wehrens
Louk T. Timmer
Eva van Rooij
News & Views29 Aug 2022
Nature Cardiovascular Research

Volume: 1, P: 798-799
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
ResearchOpen Access07 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1063-1074
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Jenny van Dongen
Fiona A. Hagenbeek
Dorret I. Boomsma
ResearchOpen Access08 Jan 2021
Molecular Psychiatry

Volume: 26, P: 2148-2162
Author Correction: The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy

Tim R. Eijgenraam
Bastiaan J. Boukens
Rudolf A. de Boer
Amendments and CorrectionsOpen Access02 Oct 2020
Scientific Reports

Volume: 10, P: 1
The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy

Tim R. Eijgenraam
Bastiaan J. Boukens
Rudolf A. de Boer
ResearchOpen Access17 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy

Henne Holstege
Sven J van der Lee
Philip Scheltens
ResearchOpen Access24 May 2017
European Journal of Human Genetics

Volume: 25, P: 973-981
Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

Tim Koopmans
Henriette van Beijnum
Kerstin Bartscherer
ResearchOpen Access17 Nov 2021
npj Regenerative Medicine

Volume: 6, P: 1-16
A comparison of genotyping arrays

Joost A. M. Verlouw
Eva Clemens
Linda Broer
ResearchOpen Access18 Jun 2021
European Journal of Human Genetics

Volume: 29, P: 1611-1624
Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
Amendments and CorrectionsOpen Access07 Mar 2024
Molecular Psychiatry

Volume: 29, P: 1216
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

W J Peyrot
S H Lee
B W J H Penninx
Research28 Apr 2015
Molecular Psychiatry

Volume: 20, P: 735-743
Anti-Mullerian hormone and endometrial cancer: a multi-cohort study

Renée T Fortner
Helena Schock
Joanne F Dorgan
ResearchOpen Access05 Sept 2017
British Journal of Cancer

Volume: 117, P: 1412-1418
Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

Molenaar et al. use scRNA-seq to profile cardiac cell gene expression changes at three time points following ischemic injury. They observe that B2M is secreted by cardiomyocytes following injury, promoting scar formation. This data may be useful in finding therapeutic targets for cardiac repair

Bas Molenaar
Louk T. Timmer
Eva van Rooij
ResearchOpen Access29 Jan 2021
Communications Biology

Volume: 4, P: 1-15

Search

Diminishing benefits of urban living for children and adolescents’ growth and development

PLD3 variants in population studies

New insights into the genetic etiology of Alzheimer’s disease and related dementias

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles

Maintaining the LYVE1 line through macrophage and lymphatic interplay in the regenerating neonatal heart

Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation

The transcriptional landscape of age in human peripheral blood

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration

ChatGPT: five priorities for research

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation

ATF3’s shielding hand to counter ischemia-reperfusion injury in cardiac macrophages

Genome-wide association study identifies 48 common genetic variants associated with handedness

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

CRISPR base editing lowers cholesterol in monkeys

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Living guidelines for generative AI — why scientists must oversee its use

Defining the pathways of heart regeneration

High-throughput methods to help understand heart disease

White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Author Correction: The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unresponsive to standard heart failure therapy

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy

Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

A comparison of genotyping arrays

Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects

Anti-Mullerian hormone and endometrial cancer: a multi-cohort study

Single-cell transcriptomics following ischemic injury identifies a role for B2M in cardiac repair

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