Gene fusion products involving protein kinases are known drivers in human cancers and actionable targets for personalized therapy. Here, the authors uncover the structural and molecular determinants that control the mechanism of autoactivation of the CCDC6-RET oncogenic fusion protein revealing a dual ATP and ADP dependent activity, with implications in cancer signaling.
- Ana Martín-Hurtado
- Julia Contreras
- Iván Plaza-Menacho
