Nature Search

Obesity rise plateaus in developed nations and accelerates in developing nations

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Bin Zhou
Nowell H. Phelps
Majid Ezzati
ResearchOpen Access13 May 2026
Nature

Volume: 653, P: 510-518
Tetrameric assembly disruption impairs CXCL4 chaperon ability for DNA and type I interferon immune amplification

Molecular analysis and functional data shed light on the crucial role of CXCL4 tetramerization in immune amplification mediated by CXCL4-DNA complexes in SSc and in other autoimmune diseases characterized by platelets activation

Giuseppe Ocone
Anna Mennella
Loredana Frasca
ResearchOpen Access19 May 2026
Communications Biology

P: 1-11
Sex and gender differences in rheumatology: clinical impact and future directions

Sex and gender influence disease presentation, diagnostic accuracy, treatment response and outcomes across rheumatology, yet remain insufficiently integrated into practice. Integrating sex-aware and gender-aware approaches can improve disease assessment, risk stratification and personalized care, advancing equity and precision in rheumatology.

Marina Pierdominici
Marta Borgi
Elena Ortona
Reviews05 May 2026
Nature Reviews Rheumatology

P: 1-16
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
Tapering and discontinuation of glucocorticoids in patients with rheumatoid arthritis treated with tofacitinib

Francesca Romana Spinelli
Cristina Garufi
Fabrizio Conti
ResearchOpen Access20 Sept 2023
Scientific Reports

Volume: 13, P: 1-7
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.

Zhaohui Gu
Michelle Churchman
Charles G. Mullighan
ResearchOpen Access08 Nov 2016
Nature Communications

Volume: 7, P: 1-10
An exploratory cross-sectional study of subclinical vascular damage in patients with polymyalgia rheumatica

Rossana Scrivo
Valeria Silvestri
Guido Valesini
ResearchOpen Access09 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Factors influencing the choice of non-biologic versus biologic immunosuppressive therapy in systemic lupus erythematosus

Alessandra Bortoluzzi
Antonio Marangoni
Gian Domenico Sebastiani
ResearchOpen Access13 Oct 2025
Scientific Reports

Volume: 15, P: 1-10
Development and validation of the sitting balance assessment for spinal cord injury (SitBASCI)

Alessia Guizzardi
Piero Artuso
Giannettore Bertagnoni
Research12 Apr 2022
Spinal Cord

Volume: 60, P: 826-830
gDNA qPCR is statistically more reliable than mRNA analysis in detecting leukemic cells to monitor CML

Alessia Rainero
Fabrizio Angaroni
Giovanni Porta
ResearchOpen Access02 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-8
Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

It’s well known that hippocampal synaptic plasticity and memory are impaired in experimental models of metabolic diseases, however, it is unclear if maternal diet or metabolic alterations around the gestational age may multigenerationally affect learning and memory. In this study, authors demonstrate that maternal high fat diet-dependent insulin resistance affects synaptic plasticity and memory of descendants until the third generation via reduced exon specific brain-derived neurotrophic factor expression in the hippocampus of descendants

Salvatore Fusco
Matteo Spinelli
Claudio Grassi
ResearchOpen Access22 Oct 2019
Nature Communications

Volume: 10, P: 1-17
Breaking down costs: rehabilitation robotics vs. usual care therapy in diverse healthcare models

Valerio Gower
Taya Hamilton
Hermano Igo Krebs
ResearchOpen Access19 Nov 2025
Scientific Reports

Volume: 15, P: 1-13
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Roger L Milne
Karoline B Kuchenbaecker
Jacques Simard
Research23 Oct 2017
Nature Genetics

Volume: 49, P: 1767-1778
GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway

Francesca Cirillo
Marianna Talia
Marcello Maggiolini
ResearchOpen Access26 Sept 2023
Cell Death Discovery

Volume: 9, P: 1-16
Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.

Matteo Spinelli
Salvatore Fusco
Claudio Grassi
ResearchOpen Access08 Dec 2017
Nature Communications

Volume: 8, P: 1-14
High fat diet affects the hippocampal expression of miRNAs targeting brain plasticity-related genes

Matteo Spinelli
Francesco Spallotta
Claudio Grassi
ResearchOpen Access23 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity

Gregory A. Raciti
Rosa Spinelli
Francesco Beguinot
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-13
Composition and geographic variation of the bacterial microbiota associated with the coelomic fluid of the sea urchin Paracentrotus lividus

Teresa Faddetta
Francesco Ardizzone
Vincenzo Cavalieri
ResearchOpen Access08 Dec 2020
Scientific Reports

Volume: 10, P: 1-12
Exploring the relationship between cardiac awareness and balance

Gerardo Salvato
Claudio Bertolotti
Gabriella Bottini
ResearchOpen Access10 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
miR-126 identifies a quiescent and chemo-resistant human B-ALL cell subset that correlates with minimal residual disease

Carolina Caserta
Silvia Nucera
Bernhard Gentner
Research28 Aug 2023
Leukemia

Volume: 37, P: 1994-2005
Stable and sustainable perovskite solar modules by optimizing blade coating nickel oxide deposition over 15 × 15 cm² area

Perovskite solar cells and have shown great promise on the lab scale, but work is needed to scale-up their fabrication. Here, blade coating is used to fabricate 15 cm×15 cm perovskite modules with a nickel oxide hole transport layer, achieving high power conversion efficiency and stability.

Farshad Jafarzadeh
Luigi Angelo Castriotta
Aldo Di Carlo
ResearchOpen Access12 Sept 2024
Communications Materials

Volume: 5, P: 1-9
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19

Gaetano Spinelli
Giuseppa Biddeci
Francesco Di Blasi
ResearchOpen Access25 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
Gradual enhancement of corticomotor excitability during cortico-cortical paired associative stimulation

Sonia Turrini
Francesca Fiori
Alessio Avenanti
ResearchOpen Access29 Aug 2022
Scientific Reports

Volume: 12, P: 1-8
Impact of baseline genetic profile and treatment on outcome and hematological toxicity in CEBPA-mutated AML

Francesco Mannelli
Matteo Piccini
Alessandro M. Vannucchi
CorrespondenceOpen Access01 Mar 2025
Blood Cancer Journal

Volume: 15, P: 1-4
Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Kimon Stamatelopoulos
Georgios Georgiopoulos
Omer Mohammed
ResearchOpen Access12 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

Alessandro Mengozzi
Georgios Georgiopoulos
Sciuto Maria
ResearchOpen Access22 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Late-onset neonatal sepsis: genetic differences by sex and involvement of the NOTCH pathway

Timothy H. Ciesielski
Xueyi Zhang
Giorgio Sirugo
Research14 Jul 2022
Pediatric Research

Volume: 93, P: 1085-1095

Search

Obesity rise plateaus in developed nations and accelerates in developing nations

Tetrameric assembly disruption impairs CXCL4 chaperon ability for DNA and type I interferon immune amplification

Sex and gender differences in rheumatology: clinical impact and future directions

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Tapering and discontinuation of glucocorticoids in patients with rheumatoid arthritis treated with tofacitinib

Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

An exploratory cross-sectional study of subclinical vascular damage in patients with polymyalgia rheumatica

Factors influencing the choice of non-biologic versus biologic immunosuppressive therapy in systemic lupus erythematosus

Development and validation of the sitting balance assessment for spinal cord injury (SitBASCI)

gDNA qPCR is statistically more reliable than mRNA analysis in detecting leukemic cells to monitor CML

Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

Breaking down costs: rehabilitation robotics vs. usual care therapy in diverse healthcare models

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

High fat diet affects the hippocampal expression of miRNAs targeting brain plasticity-related genes

Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity

Composition and geographic variation of the bacterial microbiota associated with the coelomic fluid of the sea urchin Paracentrotus lividus

Exploring the relationship between cardiac awareness and balance

miR-126 identifies a quiescent and chemo-resistant human B-ALL cell subset that correlates with minimal residual disease

Stable and sustainable perovskite solar modules by optimizing blade coating nickel oxide deposition over 15 × 15 cm² area

Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19

Gradual enhancement of corticomotor excitability during cortico-cortical paired associative stimulation

Impact of baseline genetic profile and treatment on outcome and hematological toxicity in CEBPA-mutated AML

Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

Late-onset neonatal sepsis: genetic differences by sex and involvement of the NOTCH pathway

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