Search

Lewis acid additive semicarbazide hydrochloride improves the formation of α-phase FAPbI₃-based films and promotes a homogeneous vertical distribution of A-site cations through a deprotonation–reprotonation process. The upgraded device performance reaches up to 26.12% with high stability, and mini-module perovskite solar cells achieving 21.47% (area, 11.52 cm²) demonstrate great scalability.

Heterogeneous surface frustrated Lewis pairs catalysis have been predominantly focused on metal oxide hydroxides. This study instead explores a different chemical composition space by shifting from metal oxides to metal nitrides for CO₂ photoreduction.

Results from integrative population-based investigations indicate co-occurring types of clonal hematopoiesis are highly enriched and markedly increase blood cancer risk, highlighting new opportunities for early detection and targeted surveillance of high-risk individuals.

The structure, molecular and mechanistic details of the human α1,3-fucosyltransferase FUT9 provide insight into the synthesis of diverse and modified glycan-capping Lewis antigen structures by a conserved family of mammalian fucosyltransferases.

Here, in a large-scale study of over 900 companion dogs, the authors examine how the gut microbiome varies as dogs age, identifying consistent microbial shifts associated with age, as well as associations with diet, behavior, and health.

Changing the catalytic metal centre of a non-haem iron dioxygenase to copper results in an enzyme capable of Lewis acid catalysis of new-to-nature enantioselective Conia-ene reactions.

Wong et al. uncover a nutritional dependency for acute lymphoblastic leukemia cells that spread to the central nervous system and propose using copper restriction to impair leukemia progression by disrupting nucleotide synthesis through the inhibition of electron transport chain activity.

Gene editing technologies enable precise DNA modifications but remain limited by efficiency, precision of intended edits, and flexibility. Here, authors develop chimeric oligonucleotide-directed and Cas polymerase-based systems that enhance programmable gene correction across cells and embryos.

Diorganozinc reagents (ZnR₂, e.g. R = Et, Ph, C₆F₅) are widely used as Lewis acid catalysts or Lewis base reagents, however, descriptors for predicting the influence of the R substituent are scarce. Here, by using liquid-phase X-ray spectroscopy, the authors have identified the geometric structures of diorganozincs in weakly coordinating solvents and then established Zn-specific descriptors to quantify the properties of their underlying Lewis acidity/basicity.

Selective iodoplumbate cold casting enables kinetically stabilized hybrid perovskites through control of precursor chemistry and crystallization kinetics. This strategy produces uniform 2D layers that enhance out-of-plane charge transport in 3D:2D bilayer devices, achieving power conversion efficiencies of 25.14% in small-area devices and 22.36% in mini-modules.

Here the authors report NiGa₂O_4–x(OH)_y for light-driven CO₂ hydrogenation to methanol. The surface Lewis acid–base pairs and -OH groups act as conduits for H^- /H⁺ transport to active sites, enhancing photocatalytic methanol production.

ΨDNA guides are used with Cas12 for precise, programmable targeting of cellular RNA.

Neutrophil accumulation in the ischemic heart occurs rapidly after myocardial infarction, but their early origin has been unclear. Here, the authors show that β2-adrenergic signaling drives stress-induced demargination of vascular neutrophils, supplying the first wave of early post-MI neutrophils.

The efficacy of CAR-T cells against solid tumors is still limited by immunosuppressive factors. Here, the authors show that engineering of CAR T cells with A1R enhances their efficacy against solid tumors in vitro and in vivo.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Interface engineering is promising for advancing perovskite solar cell (PSC) performance and longevity. This Review highlights three emerging strategies for interfacial optimization in PSCs: multifunctional molecular passivation, heterostructures and self-assembled monolayers. The authors discuss relevant materials, assess their limitations and outline challenges and prospective directions for future research.

This study found COVID-19 vaccination offers added protection against reinfection in children and adolescents with prior infection but variable effectiveness across variants. Findings support vaccination benefits beyond infection-acquired immunity.

Alkyl alcohols are attractive surrogates for alkyl halides in the Suzuki–Miyaura cross-coupling reactions, but methods to activate the C–O bond are underdeveloped. Now a Ni-catalysed arylation is reported that uses aryl boronic esters and tertiary alcohols, through in situ alcohol silylation.

Norovirus genotype GII.17 has been linked with a recent increase in cases in Europe and the Americas. Here, the authors investigate the genetic diversity and mutational patterns, and phenotypic differences associated with the recent circulating strain.

Vertical transmission is thought to favour beneficial host–microbe interactions, but these may also be context dependent. Here Bruijning et al. show with a model that variable environments can select for bet-hedging by hosts via imperfect vertical transmission of microbes.

This study explores the clonal architecture of aplastic anemia across age using single-cell approaches. Somatic inactivation of specific human leukocyte antigen risk alleles is a frequent event and often occurs in multiple independent events.

Post-translational site-selective formation of boronoalanine in proteins enables applications of boron for binding partner capture, footprinting of interactions with reactive oxygen species, proteolytic control and mapping of transient structures.

RNA velocity is a widely used method to predict the fate of single cells. Here the authors show that the concept can be adapted to predict the fate of individual human subjects, using RNA velocity of whole blood at a single point in time to predict future clinical outcomes and treatment responses.

The design and improvement of enzymes based on physical principles remain challenging. Now, the vibrational Stark effect has been used to demonstrate how an electrostatic model can unify the catalytic effects of distinct chemical forces in a quantitative manner and guide the design of enzyme variants that outperform their natural counterpart.

This study introduces an ion mobility–mass spectrometry method for de novo glycan structure identification, using a self-expanding database that reduces reliance on synthetic reference standards.

Divergent white matter metabolic patterns reveal a mechanistic basis for cognitive resilience and enhance prediction of future cognitive decline beyond established aging and dementia biomarkers.

Magnesium is an ideal rechargeable battery anode material, but coupling it with a low-cost sulphur cathode, requires a non-nucleophilic electrolyte. Kimet al. prepare a non-nucleophilic electrolyte from hexamethyldisilazide magnesium chloride and aluminium trichloride, and show its compatibility with a sulphur cathode.

Bacterial persister cells exhibit a transient state of antibiotic tolerance and are commonly assumed to be metabolically ‘dormant’. In this Perspective, Orman et al. re-examine common assumptions and emphasize that persisters represent a range of metabolic states, driven by internal and external factors, which may explain the inconsistent expression of classic persister hallmarks.

Light-driven approaches could lower the carbon footprint of chemical production. Here the authors use the perovskite oxide LaMn_1−xCu_xO₃ as a photocatalyst to convert ethane to ethylene and hydrogen.

Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of the tetrasaccharide sLex on the surface of basophils, resulting in cells that are less sticky and therefore less able to form the necessary adhesions for exiting the blood vessel to drive the allergic reaction.