The prevalence of hepatocellular carcinoma (HCC) is increasing worldwide. Despite the use of aggressive treatments, the survival of patients with HCC is affected by tumor recurrence and the development of extrahepatic metastases. This Review discusses the available evidence for specific multimodal approaches in the treatment of HCC. Future directions of combinatory treatment approaches are also discussed.
- Giuseppe Cabibbo
- Federica Latteri
- Antonio Craxì
