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Showing 1–13 of 13 results
Advanced filters: Author: Geert Jan Biessels Clear advanced filters

  • Cognitive dysfunction is an important comorbidity of diabetes mellitus. In this Review, Geert Jan Biessels and Florin Despa discuss the different manifestations of diabetes-mellitus-associated cognitive dysfunction. They also review the role of experimental models in improving our understanding of the pathophysiological mechanisms.

    • Geert Jan Biessels
    • Florin Despa
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 591-604

  • A recent study indicates that type 1 diabetes mellitus is associated with vascular brain lesions that affect cognition and might represent a target for preventive measures. This commentary discusses methods to ascertain vascular contributions to cerebral dysfunction in diabetes mellitus and indicates that we might only be seeing the tip of the iceberg.

    • Geert Jan Biessels
    News & Views
    Nature Reviews Endocrinology
    Volume: 11, P: 447-448

  • Diabetes mellitus is associated with cognitive decrements and alterations on brain imaging. However, important questions remain concerning risk factors and mechanisms for cerebral damage in patients with this condition. Data from two new studies shed new light on the relationship between hypoglycemia and cognitive dysfunction in older people with type 2 diabetes mellitus.

    • Geert Jan Biessels
    News & Views
    Nature Reviews Endocrinology
    Volume: 5, P: 532-534

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436

  • Type 2 diabetes mellitus is associated with an increased risk of cognitive dysfunction and Alzheimer disease. In this Review, Biessels and Reagan discuss findings from human studies and animal models which suggest that hippocampal insulin resistance is one of the mechanisms underlying the links between these disorders.

    • Geert Jan Biessels
    • Lawrence P. Reagan
    Reviews
    Nature Reviews Neuroscience
    Volume: 16, P: 660-671

  • Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

    • Matthew Bracher-Smith
    • Federico Melograna
    • Valentina Escott-Price
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Individuals with acute ischemic stroke are frequently shown to have hyperglycemia when admitted to hospital and elevated levels of blood glucose are associated with a poor prognosis. Tight glycemic control (TGC) might be an effective treatment for hyperglycemia in patients with acute ischemic stroke; however, successful and safe provision of TGC is a challenging task. This Review examines the evidence linking hyperglycemia to unfavorable prognoses in patients with acute stroke, provides a systematic review of the literature concerning TGC treatment after stroke and proposes directions on how to treat hyperglycemia in patients with stroke.

    • Nyika D. Kruyt
    • Geert Jan Biessels
    • Yvo B. Roos
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 145-155

  • Peripheral organ dysfunction can have considerable effects on brain health, contributing to neurodegeneration and dementia. This Review explores how clinical and subclinical dysfunction of specific organ systems can impact brain health and discusses the implications for dementia prevention.

    • Eric E. Smith
    • Geert Jan Biessels
    • Costantino Iadecola
    Reviews
    Nature Reviews Neurology
    Volume: 20, P: 647-659