Nature Search

Genetic insights into resting heart rate and its role in cardiovascular disease

The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

Yordi J. van de Vegte
Ruben N. Eppinga
Pim van der Harst
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-21
Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice

Secco et al. develop a genetic tracing method, CycleTrack, to monitor cardiac regeneration. CycleTrack visualizes cardiomyocyte turnover in neonatal and adult mice, after myocardial infarction, and upon stimulation with pro-regenerative microRNAs.

Ilaria Secco
Ana Backovic
Mauro Giacca
ResearchOpen Access07 Mar 2025
Nature Cardiovascular Research

Volume: 4, P: 397-411
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease.

William J. Young
Najim Lahrouchi
Patricia B. Munroe
ResearchOpen Access01 Sept 2022
Nature Communications

Volume: 13, P: 1-18
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.

Ioanna Ntalla
Lu-Chen Weng
Patricia B. Munroe
ResearchOpen Access21 May 2020
Nature Communications

Volume: 11, P: 1-12
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

The spatial and frontal QRS-T angles are electrocardiographic (ECG) predictors for arrhythmia. This work used genetic analyses to identify associated loci and pathways, and explore their relationships with other ECG traits and cardiovascular disease.

William J. Young
Jeffrey Haessler
Patricia B. Munroe
ResearchOpen Access14 Mar 2023
Nature Communications

Volume: 14, P: 1-16
The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Mutation of LMNA, encoding Lamin A/C nuclear proteins, cause dilated cardiomyopathy and conduction disorders. Here, the authors show that patient-specific iPSC-derived CMs carrying the K219T LMNA mutation have downregulated Na_v1.5 channels due to dynamic cooperation of Lamin A/C and Polycomb repressor complex 2 at the SCN5A promoter.

Nicolò Salvarani
Silvia Crasto
Elisa Di Pasquale
ResearchOpen Access22 May 2019
Nature Communications

Volume: 10, P: 1-16
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Abnormal PR interval duration is associated with risk for atrial fibrillation and heart block. Here, van Setten et al. identify 44 PR interval loci in a genome-wide association study of over 92,000 individuals and find genetic overlap with QRS duration, heart rate and atrial fibrillation.

Jessica van Setten
Jennifer A. Brody
Nona Sotoodehnia
ResearchOpen Access25 Jul 2018
Nature Communications

Volume: 9, P: 1-11
Functional screening identifies miRNAs inducing cardiac regeneration

The human heart regenerates poorly, causing insufficient healing after injury; here, microRNAs screened for the ability to induce cardiomyocyte proliferation are shown to stimulate cardiac regeneration and almost complete recovery of the heart after infarction.

Ana Eulalio
Miguel Mano
Mauro Giacca
Research05 Dec 2012
Nature

Volume: 492, P: 376-381
Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction

Regulatory T cells (Tregs) expand during pregnancy to promote tolerance towards the fetus. Here the authors show that Tregs induce proliferation of fetal and maternal cardiomyocytes during pregnancy and enhance myocardial repair via proliferation-promoting paracrine actions.

Serena Zacchigna
Valentina Martinelli
Mauro Giacca
ResearchOpen Access26 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Christopher Newton-Cheh and colleagues report genome-wide association analyses for QT interval, an electrocardiographic measure reflecting myocardial repolarization, in 100,000 individuals. They identify 35 loci associated with QT interval and highlight a role for calcium regulation in myocardial repolarization.

Dan E Arking
Sara L Pulit
Christopher Newton-Cheh
Research22 Jun 2014
Nature Genetics

Volume: 46, P: 826-836
MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

MicroRNAs delivered by adeno-associated viral vectors improve global and regional contractility, increase muscle mass and reduce scar size in a porcine model of myocardial infarction.

Khatia Gabisonia
Giulia Prosdocimo
Mauro Giacca
Research08 May 2019
Nature

Volume: 569, P: 418-422
Heart failure with mid-range or mildly reduced ejection fraction

Heart failure with mid-range or mildly reduced ejection fraction (HFmrEF) accounts for up to 25% of patients with heart failure. In this Review, Lund and colleagues provide a comprehensive overview of the epidemiology, clinical profile, prognosis and potential treatment of patients with HFmrEF.

Gianluigi Savarese
Davide Stolfo
Lars H. Lund
Reviews06 Sept 2021
Nature Reviews Cardiology

Volume: 19, P: 100-116
Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine

In this Review, Mestroni and colleagues provide an overview of the pathophysiological mechanisms underlying dilated cardiomyopathy, including both genetic and non-genetic causes, and discuss the development of novel therapies, such as small molecules and gene therapy.

Marta Gigli
Davide Stolfo
Luisa Mestroni
Reviews11 Oct 2024
Nature Reviews Cardiology

Volume: 22, P: 183-198
The genetic architecture of Plakophilin 2 cardiomyopathy

Annika M. Dries
Anna Kirillova
Victoria N. Parikh
ResearchOpen Access12 Jun 2021
Genetics in Medicine

Volume: 23, P: 1961-1968
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

Jessica van Setten
Niek Verweij
Aaron Isaacs
ResearchOpen Access24 Jan 2019
European Journal of Human Genetics

Volume: 27, P: 952-962
MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy

Elena Sommariva
Yuri D’Alessandra
Claudio Tondo
ResearchOpen Access06 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Correction to: The genetic architecture of Plakophilin 2 cardiomyopathy

Annika M. Dries
Anna Kirillova
Victoria N. Parikh
Amendments and CorrectionsOpen Access18 Aug 2021
Genetics in Medicine

Volume: 23, P: 2014

Search

Genetic insights into resting heart rate and its role in cardiovascular disease

Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Functional screening identifies miRNAs inducing cardiac regeneration

Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

Heart failure with mid-range or mildly reduced ejection fraction

Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine

The genetic architecture of Plakophilin 2 cardiomyopathy

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy

Correction to: The genetic architecture of Plakophilin 2 cardiomyopathy

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