Search

Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen where therapeutic antibiotic treatment can release toxins and disrupt gut microbiota. Here the authors demonstrate a therapeutic strategy where an engineered Escherichia coli Nissle 1917 limits the glucuronic acid utilization by EHEC.

Sodium metal halide batteries are attractive technologies for stationary electrical energy storage. Here, the authors report that planar sodium-nickel chloride batteries operated at an intermediate temperature of 190 °C display larger energy densities than tubular batteries operated at higher temperatures.

TMAO from gut microbes has been linked to some cases of atherosclerosis. Here, authors report on the use of nano-functionalized probiotics to reduce the production and absorption of TMA, reduce plasma TMAO levels, and alleviate the progression of atherosclerotic plaques.

Active lifestyle has considerable cardiac health benefits, but the metabolic and immunological background need further investigation. Here the authors show that a cardiac macrophage population, characterised by simultaneous pro-inflammatory and reparative properties, accumulate upon exercise, and these cells restore cardiac health upon transfer in a mouse model of sepsis-induced cardiomyopathy.

Here, authors report an iron flow battery, using earth-abundant materials like iron, ammonia, and phosphorous acid. This work offers a solution to reduce materials cost and extend cycle life in energy storage applications for grid decarbonization.

Inflammatory bowel disease (IBD) is a chronic immune-mediated condition. This study presents a drug-free treatment strategy for IBD that targets bacterial adhesion, utilizing mannan oligosaccharide-loaded porous microgels to selectively capture adherent-invasive E. coli and competitively inhibit bacterial colonization on the gut epithelium.

Atherosclerosis is driven in part by neutrophil elastase, an enzyme that weakens plaque stability and increases cardiovascular risk. Here, the authors show that a novel nanoprobe can non-invasively detect and quantify this enzyme in real time, helping predict plaque rupture.

Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

Conventional redox flow batteries have low energy densities. Here the authors present an aqueous redox flow battery with an ambipolar and bifunctional zinc-polyiodide electrolyte, which exhibits an energy density approaching to that of lithium ion batteries.

Single-cell RNA sequencing, whole-exome sequencing and spatial transcriptome sequencing of gallbladder adenocarcinomas from 75 patients stratifies the disease into groups with distinct clinical outcomes.

Two-dimensional Ruddlesden–Popper layered metal-halide perovskites show better performance over three-dimensional versions, but are typically based on quantum wells with random width distribution. Liang et al. show that introducing molten salt spacers gives phase-pure quantum wells and improved solar cell performance.

Heme units are immobilised in diverse heme enzymes for oxidation, and have been immobilised also in hydrogen-bonded organic frameworks. Here, the authors show the use of hydrogen-bonded organic framework to modulate the enzyme’s conformation and show different biofunction from the original.

Biodegradation of polyesters such as polylactic acid (PLA), which could serve as a carbon source for value-added chemicals, leads to CO₂ emissions. Here the authors develop a two-step catalytic process to convert PLA into methyl methacrylate, a key building-block molecule, for sustainable valorization of waste PLA.

Sodium–beta alumina batteries often need high operating temperatures, and one of the reasons is poor wettability of liquid sodium on the surface of beta alumina. Here, Lu et al. report an alloying strategy that improves the wettability, allowing the batteries to be operated at much lower temperatures.

Lipase is one of the most important industrial biocatalysts with wide applications, but its catalytic efficiency is often hindered by a closed lid conformation. Here, the authors present an aggregation-induced conformation locking strategy that enables the facile synthesis of highly activated lipase hybrid biocatalysts.

Soft tissue fabrication using digital light processing remains challenging. Here the authors present a molecular cleavage approach to achieve high-performance bioprinting of constructs with tissue-matching mechanical properties and structural complexity.

Manufacturing complexities, low yield and stability issues have hampered the clinical translation and scaling-up of immunoliposomes to meet the needs of pharmaceutical-grade products. The authors propose a one-step method of incorporating chimeric nanobodies tagged to hydrophobic linkers into liposomes, allowing targeted delivery of small-molecule anti-cancer drugs to tumours.

The NLRP3 inflammasome controls the response of the host to pathogens; precise regulation is required to limit autoimmune diseases. Here, the authors identify the E3 ligase TRIM31 that aids the ubiquitin-mediated proteasomal degradation of NLRP3, which may be a therapeutic target for alleviating disease.

Harsh operating conditions, such as high temperatures, hinder the grid-scale application of liquid metal batteries (LMBs). Now, their operating temperature is shown to be substantially lowered thanks to a lithium-ion-conducting solid-state electrolyte.

LMNA-related dilated cardiomyopathy (DCM) is an inherited cardiomyopathy featured by early-onset lethal arrhythmias, but the underlying mechanisms remain unclear. Here, the authors show that manipulation of impaired SIRT1 activity and excessive oxidative stress may offer new therapeutic strategies for LMNA-related DCM.

Active targeting and cytosolic delivery of therapeutic payloads are challenging in small extracellular vesicle-based drug delivery systems. Here, the authors engineer fusogen and targeting moiety co-functionalized cell-derived nanovesicles, which can selectively bind to target cells and efficiently fulfill cytosolic delivery through membrane fusion.

Annotating functional elements of the genome helps the interpretation of genetic variation. Here, the authors compile functional genomics data for the pig genome over 14 tissues with 15 different chromatin states, integrate the data with WGS and GWAS data, and compare conservation of regulatory elements across mouse and human tissues.

The hydroxyl radical is generated during radiotherapy and ferroptosis and accurate imaging of this reactive oxygen species may permit the monitoring of response to therapy. Here, the authors develop a ratiometric probe for accurate imaging of hydroxyl radical generation in vivo.

Strigolactones (SLs), key regulators of plant growth, are believed to mediate their responses through a proposed receptor (D14) that interacts with an F-box protein (D3) to form a D14–SCF^D3 protein complex; here the perception of SLs by the D14–SCF^D3 complex and the control of gene expression are linked by the finding that DWARF 53, a repressor protein of SL signalling, interacts with the D14–SCF^D3 complex and is ubiquitinated and degraded in a SL-dependent manner.

Integration of nanomaterials and enzymes has potential in the development of robust biocatalysts, but preparation can still be technically challenging. Here, the authors report the preparation of a hydrogen-bonded organic framework biocatalyst and its use as an immunosensor.

It is challenging to produce biomass FG continuously due to the lack of an integrated device. Here, we create an integrated automatic system with energy requirement-oriented allocation to achieve continuous biomass FG production with a much lower carbon footprint.

Layered double hydroxides (LDH) are ideal for charge storage, however, the sluggish reaction dynamics are obstacle to their development. Here, triggered by mismatching integration of Mn sites, the authors configure wrinkled Mn/NiCo-LDH with strains and defects, where promoted mass & charge transport behaviors are realized.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

CPT2 downregulation promotes colorectal cancer proliferation by enhancing GPAT4-mediated glycerophospholipid biosynthesis and activating selective autophagy.

Volumetric additive manufacturing of protein scaffolds has a wide range of possible biomedical applications. Here the authors report on the bioprinting of unmodified silk sericin and silk fibroin inks with shape-memory and tuneable mechanical properties and demonstrate the potential of the inks in different applications.

Qui et al. perform co-detection by indexing profiling of 401 hepatocellular carcinoma patient samples and identify a role for vimentin^high macrophages in instructing an immune-suppressive microenvironment by enhancing the suppressive activity of regulatory T cells via interleukin-1β.

Biomolecule-metal-organic-frameworks allow for the creation of hybrid materials with desired biological and chemical function. Here, the authors refine the structure-function relationship by identifying the atomic-layer structure of the hybrids and show differences in structure upon different crystallisation pathways.

Many of the molecular targets of strigolactones—plant hormones involved in development and in interactions with symbiotic and parasitic organisms—are uncovered, revealing how strigolactones function and an intriguing role for self-regulation of a downstream transcription factor.

We present a protocol for the encapsulation and stabilization of enzymes by using hydrogen-bonded organic frameworks (HOFs)—enzyme@HOF-101—along with procedures for their material characterization and testing of their biocatalytic performance.