Amyotrophic lateral sclerosis is a devastating neurodegenerative motor neuron disease that results in progressive loss of bulbar and limb function. In this Review, Hardiman et al. provide an overview of the clinical aspects of the disease, discussing epidemiology, clinical presentation, diagnosis and management, with an emphasis on recent key advances.
- Orla Hardiman
- Leonard H. van den Berg
- Matthew C. Kiernan
