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Showing 1–50 of 55 results

Advanced filters: Author: HIROSHI AZUMA Clear advanced filters

IQ in Japan and the United States

HAROLD W. STEVENSON
HIROSHI AZUMA
Research17 Nov 1983
Nature

Volume: 306, P: 291-292
Relationship between Cell Morphology and Intracellular Potassium Concentration in Candida albicans

Hiroshi Watanabe
Masayuki Azuma
Hiroshi Ooshima
Research01 May 2006
The Journal of Antibiotics

Volume: 59, P: 281-287
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

Yukiko Kurihara
Hiroki Kurihara
Yoshio Yazaki
Research21 Apr 1994
Nature

Volume: 368, P: 703-710
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Hiroshi Suzuki
Yukiko Kurihara
Tatsuhiko Kodama
Research20 Mar 1997
Nature

Volume: 386, P: 292-296
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Correction: Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Yasuhito Yahara
Hiroshi Takemori
Noriyuki Tsumaki
Amendments and CorrectionsOpen Access27 Jun 2016
Nature Communications

Volume: 7, P: 1-2
Valinomycin Affects the Morphology of Candida albicans

Hiroshi Watanabe
Masayuki Azuma
Hiroshi Ooshima
Research01 Dec 2005
The Journal of Antibiotics

Volume: 58, P: 753-758
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Masaki Okamoto
Kiminori Fujimoto
Tomoaki Hoshino
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion

A new system to monitor the effects of nucleosome depletion in Xenopus egg extracts reveals that nucleosomes are required for spindle assembly and for recruitment of nuclear pore complex (NPC) components to the nuclear envelope for NPC formation.

Christian Zierhut
Christopher Jenness
Hironori Funabiki
Research22 Jun 2014
Nature Structural & Molecular Biology

Volume: 21, P: 617-625
Relationship between Pb ion off-centering and lone pair electrons

Kosuke Kurushima
Hiroshi Nakajima
Shigeo Mori
ResearchOpen Access18 Mar 2025
Scientific Reports

Volume: 15, P: 1-7
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Carminerin contributes to chondrocyte calcification during endochondral ossification

Takashi Yamada
Hirotaka Kawano
Hiroshi Kawaguchi
Research07 May 2006
Nature Medicine

Volume: 12, P: 665-670
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis.

Yasuhito Yahara
Hiroshi Takemori
Noriyuki Tsumaki
ResearchOpen Access24 Mar 2016
Nature Communications

Volume: 7, P: 1-14
Relationship between visual acuity and visual field and its reproducibility in patients with retinitis pigmentosa

Ryo Asaoka
Manabu Miyata
Tatsuya Inoue
Research20 Apr 2022
Eye

Volume: 37, P: 1094-1099
Development and validation of a visual field cluster in retinitis pigmentosa

Takashi Omoto
Akio Oishi
Tatsuya Inoue
ResearchOpen Access06 May 2021
Scientific Reports

Volume: 11, P: 1-7
Assessment of the choroidal structure in pregnant women in the first trimester

Keiko Azuma
Atsushi Okubo
Ryo Obata
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-7
Evaluation of focal damage in the retinal pigment epithelium layer in serous retinal pigment epithelium detachment

Masahiro Miura
Shuichi Makita
Hiroshi Goto
ResearchOpen Access01 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Corneal biomechanical properties are associated with the activity and prognosis of Angioid Streaks

Shotaro Asano
Kosuke Nakajima
Ryo Asaoka
ResearchOpen Access25 May 2018
Scientific Reports

Volume: 8, P: 1-7
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Asynchrony between Antarctic temperature and CO₂ associated with obliquity over the past 720,000 years

The Antarctic temperature record displays a puzzling asynchrony with changes in CO₂ through glacial cycles. Here, the authors show that a 720,000-year Antarctic temperature record is affected by variations in obliquity-induced local insolation that are associated with phase modulation of eccentricity cycle.

Ryu Uemura
Hideaki Motoyama
Yoshiyuki Fujii
ResearchOpen Access06 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease

Inflammatory bowel disease (IBD) is initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Here, the authors show that inhibition of the calreticulin binding to integrin α subunits ameliorates the severity of IBD in animal models.

Masayoshi Ohkuro
Jun-Dal Kim
Akiyoshi Fukamizu
ResearchOpen Access17 May 2018
Nature Communications

Volume: 9, P: 1-10
Comprehensive analysis of syndromic hearing loss patients in Japan

Michie Ideura
Shin-ya Nishio
Shin-ichi Usami
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-13
Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry

Hisashi Fukuyama
Hiroto Ishikawa
Shin Yamane
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Three-dimensional motion control of an untethered magnetic object using three rotating permanent magnets

Hiroshi Sakuma
ResearchOpen Access23 Oct 2023
Scientific Reports

Volume: 13, P: 1-8
Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging

Kazuo Yamagata
Kouhei Nagai
Akira Iritani
ResearchOpen Access11 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Surface modification of poly(phenylene sulfide) using photoinitiated chlorine dioxide radical as an oxidant

Surface oxidation method using chlorine dioxide radical (ClO₂^•) for poly(phenylene sulfide) (PPS) was developed. During the oxidation reaction, sulfonyl groups and sulfite groups were successfully introduced to the surface of the PPS films. The water contact angle of the surface of the PPS film decreased dramatically after the oxidation, indicating that the surface hydrophilicity was improved. Electroless plating demonstrates that typical metals could be tightly deposited on the surface of oxidized PPS film and cannot be removed. This method provides an effective, clean, energy-saving treatment for super engineering plastics.

Zeying Cao
Yu-I Hsu
Hiroshi Uyama
Research12 Aug 2021
Polymer Journal

Volume: 53, P: 1231-1239
A monolithically integrated polarization entangled photon pair source on a silicon chip

Nobuyuki Matsuda
Hanna Le Jeannic
Hiroki Takesue
ResearchOpen Access12 Nov 2012
Scientific Reports

Volume: 2, P: 1-7
Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model

Atsushi Mima
Azuma Kimura
Kenji Osafune
ResearchOpen Access07 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Versatile application of fast green FCF as a visible cholangiogram in adult mice to medium-sized mammals

Tomoyuki Niimi
Nanae Miyazaki
Yoshiakira Kanai
ResearchOpen Access16 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Author Correction: New theropod dinosaur from the Lower Cretaceous of Japan provides critical implications for the early evolution of ornithomimosaurs

Soki Hattori
Masateru Shibata
Yoichi Azuma
Amendments and CorrectionsOpen Access28 Sept 2023
Scientific Reports

Volume: 13, P: 1
Objective evaluation of choroidal melanin loss in patients with Vogt–Koyanagi–Harada disease using polarization-sensitive optical coherence tomography

Masahiro Miura
Shuichi Makita
Hiroshi Goto
ResearchOpen Access03 Mar 2022
Scientific Reports

Volume: 12, P: 1-11
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Mutation spectrum and phenotypic variation in nine patients with SOX2 abnormalities

Junichi Suzuki
Noriyuki Azuma
Maki Fukami
Research08 May 2014
Journal of Human Genetics

Volume: 59, P: 353-356
Improvement of the rheological properties of trans-1,4-polyisoprene from Eucommia ulmoides Oliver by tri-branched poly(ricinoleic acid)

Amorphous and flexible tri-branched poly(ricinoleic acid) was introduced to semi-crystalline and rigid trans-1,4-polyisoprene from Eucommia ulmoides Oliver to improve the processing ability.

Bo-xing Zhang
Jun-ichi Azuma
Hiroshi Uyama
Research16 Mar 2016
Polymer Journal

Volume: 48, P: 821-827
Impact of gallbladder hypoplasia on hilar hepatic ducts in biliary atresia

Miyazaki, Takami et al. assess the relationship between biliary atresia and the gallbladder in Sox17 haploinsufficient mice and human biliary atresia patients. They report findings on the perinatal pathological condition in which abnormalities in the gallbladder wall extend to the intrahepatic bile duct through the common hepatic duct.

Nanae Miyazaki
Shohei Takami
Yoshiakira Kanai
ResearchOpen Access11 Jun 2024
Communications Medicine

Volume: 4, P: 1-12
Age-specific assessment of initial hemoglobin levels and shock index for predicting life-saving interventions in pediatric blunt liver and spleen injuries

Tetsuya Yumoto
Takafumi Obara
Tamotsu Gotou
ResearchOpen Access12 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
New theropod dinosaur from the Lower Cretaceous of Japan provides critical implications for the early evolution of ornithomimosaurs

Soki Hattori
Masateru Shibata
Yoichi Azuma
ResearchOpen Access07 Sept 2023
Scientific Reports

Volume: 13, P: 1-16
Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis

Erina Nakahara
Keiko Shimojima Yamamoto
Hitoshi Kanno
ResearchOpen Access02 Mar 2023
Human Genome Variation

Volume: 10, P: 1-6
Genetic abnormalities in a large cohort of Coffin–Siris syndrome patients

Futoshi Sekiguchi
Yoshinori Tsurusaki
Naomichi Matsumoto
Research17 Sept 2019
Journal of Human Genetics

Volume: 64, P: 1173-1186
The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish

Jun Hirayama
Yikelamu Alifu
Hiroshi Nishina
ResearchOpen Access17 Jan 2019
Scientific Reports

Volume: 9, P: 1-15
A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration

Kenji Yamashiro
Keisuke Mori
Nagahisa Yoshimura
ResearchOpen Access23 Aug 2017
Scientific Reports

Volume: 7, P: 1-8
The mevalonate pathway regulates primitive streak formation via protein farnesylation

Yoshimi Okamoto-Uchida
Ruoxing Yu
Hiroshi Nishina
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-11
A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS

Seiji Yamamoto
Masashi Muramatsu
Masakiyo Sasahara
ResearchOpen Access20 Jun 2017
Scientific Reports

Volume: 7, P: 1-16
Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes

Seiji Yamamoto
Shumpei Niida
Masakiyo Sasahara
ResearchOpen Access17 Feb 2015
Scientific Reports

Volume: 5, P: 1-10

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