Nature Search

RK-95113, a New Angiogenesis Inhibitor Produced by Aspergillus fumigatus

Yukihiro Asami
Hideaki Kakeya
Hiroyuki Osada
Research01 Nov 2006
The Journal of Antibiotics

Volume: 59, P: 724-728
Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation

Hiroshi Kamiyama
Takeo Usui
Hiroyuki Osada
Research01 Feb 2008
The Journal of Antibiotics

Volume: 61, P: 94-97
Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis

Masahiko Watabe
Hideaki Kakeya
Hiroyuki Osada
Research17 Sept 1999
Oncogene

Volume: 18, P: 5211-5220
Isolation and structure determination of streptospherins B–F, novel cancer stem cell inhibitors, produced by Streptomyces sp. KUSC-240

Morihiro Shibasaki
Hiroaki Ikeda
Hideaki Kakeya
Research19 Jun 2025
The Journal of Antibiotics

Volume: 78, P: 535-541
A new pyranonaphthoquinone, actinoquinonal A, and its congeners from the combined-culture of Streptomyces sp. 23–50 and Tsukamurella pulmonis TP-B0596

Kazuki Yanagisawa
Kensuke Kaneko
Hideaki Kakeya
Research22 Apr 2025
The Journal of Antibiotics

Volume: 78, P: 350-358
Identification of the polyether ionophore lenoremycin through a new screening strategy for targeting cancer stem cells

Hiroaki Ikeda
Misato Kawami
Hideaki Kakeya
Research08 Oct 2022
The Journal of Antibiotics

Volume: 75, P: 671-678
Longicatenamides A–D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596

Yulu Jiang
Takumi Matsumoto
Hideaki Kakeya
Research22 Jan 2021
The Journal of Antibiotics

Volume: 74, P: 307-316
Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

The target of theonellamides, a family of bicyclic peptides with antifungal activity, has previously proven elusive. A combination of chemical-genomic profiling and biochemical and cellular analysis now reveals that these compounds target sterols to activate Rho1 signaling and induce membrane damage.

Shinichi Nishimura
Yuko Arita
Minoru Yoshida
Research13 Jun 2010
Nature Chemical Biology

Volume: 6, P: 519-526
In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes

Akihiro Moriyama
Naohiro Katagiri
Hideaki Kakeya
ResearchOpen Access30 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

When stabilized, HIF-1 can activate adaptation to hypoxia and metastasis. Here the authors show that upregulation of Ubiquitin C-terminal hydrolase-L1 in human cancers promotes metastasis and correlates with poor prognosis because of its role in opposing ubiquitin-mediated degradation of HIF-1.

Yoko Goto
Lihua Zeng
Hiroshi Harada
ResearchOpen Access23 Jan 2015
Nature Communications

Volume: 6, P: 1-13
A bridge between chemistry and biology

Chemical biology is an interdisciplinary field that is undergoing rapid expansion around the globe. Recently, the Japanese Society for Chemical Biology sponsored its inaugural scientific meeting to discuss research at the interface of chemistry and biology.

Kazuya Kikuchi
Hideaki Kakeya
News & Views01 Aug 2006
Nature Chemical Biology

Volume: 2, P: 392-394
Mechanistic study of the retro-aza-Michael reaction in saccharothriolide L: identification of 2-amino-4-methylphenol as an effective protecting tool for the Michael acceptor

Shan Lu
Lingling Ren
Hideaki Kakeya
Research24 May 2024
The Journal of Antibiotics

Volume: 77, P: 544-547
Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10–13

Di Mao
Pengwei Yu
Hideaki Kakeya
Research10 Jan 2024
The Journal of Antibiotics

Volume: 77, P: 189-192
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis

Chengqian Pan
Hiroaki Ikeda
Hideaki Kakeya
Research30 Oct 2023
The Journal of Antibiotics

Volume: 77, P: 66-70
Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast

Akihiko Kanou
Shinichi Nishimura
Hideaki Kakeya
Research20 Apr 2020
The Journal of Antibiotics

Volume: 73, P: 574-580
Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506

Shan Lu
Shinichi Nishimura
Hideaki Kakeya
Research21 Dec 2016
The Journal of Antibiotics

Volume: 70, P: 718-720
RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

Hideaki Kakeya
Daisuke Kaida
Hiroyuki Osada
Research09 Sept 2015
The Journal of Antibiotics

Volume: 69, P: 121-123
The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice

Kana Shimizu
Yoichi Sunagawa
Tatsuya Morimoto
ResearchOpen Access28 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei

Kensuke Kaneko
Marika Mieda
Hideaki Kakeya
Research25 Mar 2024
The Journal of Antibiotics

Volume: 77, P: 353-364
A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

Yutaka Furutani
Yoshinori Hirano
Tomokazu Matsuura
ResearchOpen Access22 Dec 2023
Cell Death Discovery

Volume: 9, P: 1-13
Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity

Chemical variational autoencoder (VAE) is a deep learning method for constructing chemical latent spaces, however, the current chemical VAE variants are limited in their ability to handle complex compound structures like natural products. Here, the authors develop a variational autoencoder that can handle natural products and demonstrate its utility as an in silico drug discovery tool.

Toshiki Ochiai
Tensei Inukai
Yasubumi Sakakibara
ResearchOpen Access16 Nov 2023
Communications Chemistry

Volume: 6, P: 1-14
Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy

Hiroaki Ikeda
Hideaki Kakeya
Reviews30 Jul 2021
The Journal of Antibiotics

Volume: 74, P: 687-695
Methylation deficiency disrupts biological rhythms from bacteria to humans

Fustin et al. reveal the evolutionarily conserved link between methyl metabolism and biological clocks. This study suggests the possibility of translating fundamental understanding of methylation deficiencies to clinical applications.

Jean-Michel Fustin
Shiqi Ye
Hitoshi Okamura
ResearchOpen Access06 May 2020
Communications Biology

Volume: 3, P: 1-14
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans

Jean-Michel Fustin
Shiqi Ye
Hitoshi Okamura
Amendments and CorrectionsOpen Access04 Jun 2020
Communications Biology

Volume: 3, P: 1

Search

RK-95113, a New Angiogenesis Inhibitor Produced by Aspergillus fumigatus

Fungal Metabolite, Epoxyquinol B, Crosslinks Proteins by Epoxy-thiol Conjugation

Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis

Isolation and structure determination of streptospherins B–F, novel cancer stem cell inhibitors, produced by Streptomyces sp. KUSC-240

A new pyranonaphthoquinone, actinoquinonal A, and its congeners from the combined-culture of Streptomyces sp. 23–50 and Tsukamurella pulmonis TP-B0596

Identification of the polyether ionophore lenoremycin through a new screening strategy for targeting cancer stem cells

Longicatenamides A–D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596

Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling

In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

A bridge between chemistry and biology

Mechanistic study of the retro-aza-Michael reaction in saccharothriolide L: identification of 2-amino-4-methylphenol as an effective protecting tool for the Michael acceptor

Precezomycin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10–13

Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis

Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast

Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice

Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei

A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor

Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity

Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy

Methylation deficiency disrupts biological rhythms from bacteria to humans

Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans

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