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Showing 1–50 of 55 results

Advanced filters: Author: Hiroshi Suga Clear advanced filters

Thermodynamic Studies of Solid Polyethers. IV. Poly(octamethylene oxide), –[–(CH₂)₈O–]–n

Shohei Yoshida
Hiroshi Suga
Syûzô Seki
Research01 Oct 1973
Polymer Journal

Volume: 5, P: 33-40
Thermodynamic Studies of Solid Polyethers. II. Heat Capacity of Poly(oxacyclobutane), –[–(CH₂)₃O–]–n, between 1.4 and 330°K

Shohei Yoshida
Hiroshi Suga
Syûzô Seki
Research01 Oct 1973
Polymer Journal

Volume: 5, P: 11-24
Thermodynamic Studies of Solid Polyethers. III. Poly(tetrahydrofuran), –[–(CH₂)₄O–]–n

Shohei Yoshida
Hiroshi Suga
Syûzô Seki
Research01 Oct 1973
Polymer Journal

Volume: 5, P: 25-32
The Capsaspora genome reveals a complex unicellular prehistory of animals

Unicellular ancestors of metazoans can provide significant insights into the origin of multicellularity. Suga et al. present the first complete genome of the filasterean Capsaspora owczarzakiand suggest an evolutionary mechanism for the transition from unicellular protists to metazoans.

Hiroshi Suga
Zehua Chen
Iñaki Ruiz-Trillo
ResearchOpen Access14 Aug 2013
Nature Communications

Volume: 4, P: 1-9
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Energetics of proton release on the first oxidation step in the water-oxidizing enzyme

The availability of crystal structures of photosystem II opens up the possibility of gaining insights into its mechanism. Here, the authors use a computational approach and propose a deprotonation event at O4 followed by long-range proton-transfer along a chain of strongly bonded water molecules.

Keisuke Saito
A. William Rutherford
Hiroshi Ishikita
ResearchOpen Access07 Oct 2015
Nature Communications

Volume: 6, P: 1-10
Correction: Corrigendum: A highly flexible tRNA acylation method for non-natural polypeptide synthesis

Hiroshi Murakami
Atsushi Ohta
Hiroaki Suga
Amendments and Corrections01 Aug 2006
Nature Methods

Volume: 3, P: 657
Highly stable, extremely high-temperature, nonvolatile memory based on resistance switching in polycrystalline Pt nanogaps

Hiroshi Suga
Hiroya Suzuki
Yasuhisa Naitoh
ResearchOpen Access11 Oct 2016
Scientific Reports

Volume: 6, P: 1-9
Oxygen-evolving photosystem II structures during S₁–S₂–S₃ transitions

Serial femtosecond crystallography reveals the structural dynamics of photosystem II during the S-state transitions that produce dioxygen, providing insight into electron transfer, water insertion, proton release and O–O bond formation on sub-microsecond timescales.

Hongjie Li
Yoshiki Nakajima
Jian-Ren Shen
ResearchOpen Access31 Jan 2024
Nature

Volume: 626, P: 670-677
A highly flexible tRNA acylation method for non-natural polypeptide synthesis

Hiroshi Murakami
Atsushi Ohta
Hiroaki Suga
Research20 Apr 2006
Nature Methods

Volume: 3, P: 357-359
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
High-temperature non-volatile memory technology

Non-volatile memory devices capable of recording and reading information at temperatures up to 600 °C can be built using aluminium scandium nitride ferroelectric diodes.

Hiroshi Suga
News & Views22 May 2024
Nature Electronics

Volume: 7, P: 330-331
The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B

Kizuki Watanabe
Shin-ya Nishio
Shunsuke Kondo
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-19
Chromatin loops are an ancestral hallmark of the animal regulatory genome

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of genome architecture and spatial genome regulation emerged early in animal evolution.

Iana V. Kim
Cristina Navarrete
Arnau Sebé-Pedrós
ResearchOpen Access07 May 2025
Nature

Volume: 642, P: 1097-1105
Diverse backbone-cyclized peptides via codon reprogramming

Takashi Kawakami
Atsushi Ohta
Hiroaki Suga
Research25 Oct 2009
Nature Chemical Biology

Volume: 5, P: 888-890
Enantioselective acyl transfer catalysis by a combination of common catalytic motifs and electrostatic interactions

Nucleophilic catalysts are widely used for acyl transfer reactions, but chiral variants can be difficult to design or synthesise. Here, the authors report catalysts with chirality imparted from a binaphtyl moiety with tert-alcohol unit that show both high activity and enantioselectivity for a range of acyl transfer reactions.

Hiroki Mandai
Kazuki Fujii
Seiji Suga
ResearchOpen Access15 Apr 2016
Nature Communications

Volume: 7, P: 1-11
Establishment of a stem cell administration imaging method in bleomycin-induced pulmonary fibrosis mouse models

Saho Morita
Mayumi Iwatake
Hiroshi Yukawa
ResearchOpen Access14 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme

Flexizyme is an in vitro evolved ribozyme which can specifically add an amino acid onto the terminal 3'OH of a tRNA. The structure of flexizyme joined to a tRNA mimic is solved. Interestingly, the RNA displays many of the known aminoacyl tRNA synthetase–tRNA interactions, approaches the tRNA in a similar manner, and exhibits an induced fit conformation that enhances specificity.

Hong Xiao
Hiroshi Murakami
Adrian R. Ferré-D’Amaré
Research01 Jul 2008
Nature

Volume: 454, P: 358-361
Variations of organic functional chemistry in carbonaceous matter from the asteroid 162173 Ryugu

A new study of samples from the Ryugu asteroid reveal a greater diversity of macromolecular organic matter than that found in related carbonaceous meteorites. Researchers find distinct populations of alkyl-aromatic grains, and organic carbonate is found with coarse-grained clay minerals

Bradley De Gregorio
George D. Cody
Yuichi Tsuda
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Structural basis for high selectivity of a rice silicon channel Lsi1

The rice Lsi1 aquaporin mediates uptake of silicic acid via the roots. Here the authors show the crystal structure of rice Lsi1 and characterize a unique five residue hydrophilic selectivity filter providing a structural basis for the highly selective activity of Lsi1 in Si uptake.

Yasunori Saitoh
Namiki Mitani-Ueno
Michihiro Suga
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-14
A new primate model of hypophyseal dysfunction

Teppei Kawabata
Hidetaka Suga
Toshihiko Wakabayashi
ResearchOpen Access24 May 2021
Scientific Reports

Volume: 11, P: 1-7
Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by ¹⁸F-FDG PET/CT texture analysis

Makito Suga
Ryuichi Nishii
Tatsuya Higashi
ResearchOpen Access01 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models

Here, the authors report bi-functional, wide tropic macrocycles that bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion and show efficacy in preventing severe pneumonia at later stages of infection in mouse and non-human primate cynomolgus macaque models.

Makoto Saito
Yasushi Itoh
Michinori Kohara
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-11
Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro-o
Yutaka Matsumura
Yo-ichi Nabeshima
Research06 Nov 1997
Nature

Volume: 390, P: 45-51
Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes

The repertoire of amino acids available for ribosomal peptide synthesis is limited by the genetic code. Now, a method to reduce the redundancy of codons has been developed based on the artificial division of codon boxes. This method enables non-proteinogenic amino acids to be included in peptides without sacrificing proteinogenic ones.

Yoshihiko Iwane
Azusa Hitomi
Hiroaki Suga
Research01 Feb 2016
Nature Chemistry

Volume: 8, P: 317-325
Bases in the anticodon loop of tRNA^Ala_GGC prevent misreading

The conserved A32-U38 pair in the anticodon loop of tRNA^Ala_GGC is now shown to be important for accurate decoding. Using tRNA^Ala variants in this pair in an in vitro translation system showed that some variants could decode both the cognate and a near-cognate codons with high efficiency. These mutants tRNA were toxic in vivo, supporting the biological relevance of this accuracy determinant.

Hiroshi Murakami
Atsushi Ohta
Hiroaki Suga
Research22 Mar 2009
Nature Structural & Molecular Biology

Volume: 16, P: 353-358
Conformation of Block Copolypeptides of γ-Benzyl L-GIutamate and ε-Carbobenzoxy L-Lysine in m-Cresol

Noboru Nishioka
Akio Teramoto
Hiroshi Fujita
Research01 Jan 1976
Polymer Journal

Volume: 8, P: 121-128
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Structure and function of Zucchini endoribonuclease in piRNA biogenesis

Zucchini has been identified as an endoribonuclease responsible for the maturation of small RNA molecules that protect the genome from the damaging effects of unrestrained expression of mobile elements.

Hiroshi Nishimasu
Hirotsugu Ishizu
Osamu Nureki
Research14 Oct 2012
Nature

Volume: 491, P: 284-287
A deep learning approach to predict differentiation outcomes in hypothalamic-pituitary organoids

A deep learning model predicts gene expression and subsequent adrenocorticotropic hormone secretory function in the differentiation process of hypothalamic–pituitary organoids.

Tomoyoshi Asano
Hidetaka Suga
Hiroshi Arima
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-10
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice

Akira Mizoguchi
Ryoichi Banno
Hiroshi Arima
ResearchOpen Access18 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
GABA_B receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice

Runan Sun
Taku Tsunekawa
Hiroshi Arima
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-11
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
The association between prehospital vital signs of children and their critical clinical outcomes at hospitals

Hiroshi Kurosawa
Yuko Shiima
Kazumoto Iijima
ResearchOpen Access25 Mar 2022
Scientific Reports

Volume: 12, P: 1-7
Infiltrating CCR2⁺ monocytes and their progenies, fibrocytes, contribute to colon fibrosis by inhibiting collagen degradation through the production of TIMP-1

Naoki Kuroda
Masahiro Masuya
Naoyuki Katayama
ResearchOpen Access12 Jun 2019
Scientific Reports

Volume: 9, P: 1-17
Next-generation sequencing analysis of multiplex families with atypical psychosis

Tatsushi Okayama
Yasuyuki Hashiguchi
Tetsufumi Kanazawa
ResearchOpen Access15 Oct 2018
Translational Psychiatry

Volume: 8, P: 1-7
Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state

Hajime Ozaki
Hidetaka Suga
Hiroshi Arima
ResearchOpen Access17 Oct 2022
Scientific Reports

Volume: 12, P: 1-11
Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice

Yohei Kawaguchi
Daisuke Hagiwara
Hiroshi Arima
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-13
Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

Norio Okada
Shintaro Iwama
Hiroshi Arima
ResearchOpen Access03 Feb 2020
British Journal of Cancer

Volume: 122, P: 771-777
Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors

Koichiro Ogawa
Hidetaka Suga
Hiroshi Arima
ResearchOpen Access26 Feb 2018
Scientific Reports

Volume: 8, P: 1-10
Assessment of catabolic state in infants with the use of urinary titin N-fragment

Sachiyo Fukushima
Nobuto Nakanishi
Masafumi Matsuo
Research17 Jul 2021
Pediatric Research

Volume: 91, P: 1748-1753
Ichthyosporea: a window into the origin of animals

Ichthyosporea are unicellular eukaryotes crucial for understanding animal origins and evolution. This Review outlines the history and recent advancements in ichthyosporean biology, genomics, and genetics, and provides insight into their environmental diversity.

Victoria Shabardina
Jennah E. Dharamshi
Iñaki Ruiz-Trillo
ReviewsOpen Access29 Jul 2024
Communications Biology

Volume: 7, P: 1-13
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells

Ken-Ichi Suehiro
Akira Suto
Hiroshi Nakajima
Research09 Mar 2020
Cellular & Molecular Immunology

Volume: 18, P: 1729-1738
Enhanced proliferation of HeLa cells on PLLA-PCL and PLGA-PCL multiblock copolymers

HeLa cell culture was enhanced on the film prepared from poly(l-lactide)-poly(ɛ-caprolactone) (PLLA-PCL) and poly(L-lactide-co-glycolide)-poly(ɛ-caprolactone) (PLGA-PCL) multiblock copolymers (MBCs) without any coatings or treatments. (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) reduction assay quantitatively showed the enhanced proliferation of HeLa cells on the MBC films in comparison with the film prepared from a PLLA-PCL random copolymer. The microphase-separated morphology of the multiblock copolymers plays an important role in protein adhesion behavior and subsequent cell proliferation.

Takahiro Suga
Nguyen T Xuyen
Taku Tamura
Research05 Apr 2017
Polymer Journal

Volume: 49, P: 567-573
Relationship of early acute complications and insertion site in push method percutaneous endoscopic gastrostomy

Hiroshi Suzuki
Satoru Joshita
Takeji Umemura
ResearchOpen Access25 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice

Masaaki Ito
Shintaro Iwama
Hiroshi Arima
ResearchOpen Access12 Apr 2023
Scientific Reports

Volume: 13, P: 1-11
Peripheral T cell cytotoxicity predicts the efficacy of anti-PD-1 therapy for advanced non-small cell lung cancer patients

Kota Iwahori
Takeshi Uenami
Hisashi Wada
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-11

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