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This study finds that the most dangerous tick-borne viruses infect many tick and animal species, boosting their chances of reaching humans. Bird migration helps spread them worldwide, and genetic adaptation may increase their ability to infect people.

Efficient removal of nitrogen-rich wastewater while recovering valuable chemicals remains a major challenge for sustainable water treatment. Here, the authors develop an integrated electrochemical membrane system that achieves near-complete urea removal and effective recovery of potassium hydroxide.

This study examines severe lattice distortions in concentrated solid solutions, enabling an energy landscape that immobilizes vacancies and interstitials which curbs their harmful evolution under irradiation conditions.

Here, the authors report a strategy using picolinoylated N,S-benzylidene thioacetal dipeptides to facilitate the chemical synthesis of difficult peptides and proteins.

Excess free fatty acids are toxic to cells. Here, the authors identify TMEM120A as a GPAT4 activator that promotes the incorporation of medium- and long-chain fatty acids into glycerolipids to prevent lipotoxicity.

Single-atom catalysts offer high efficiency for hydrogen evolution, but control of metal–support interactions remains challenging. Here, the authors report a rhodium single-atom catalyst platform enabling continuous tuning of metal–support frontier orbital interactions via anion-engineered supports.

Acoustic sensing devices are important to realize human‒machine interfaces. Here, the authors report the fabrication of freestanding reduced graphene oxide membranes with a diameter-to-thickness ratio of ~10⁶, leading to a static pressure responsivity of ~ 500 μm/Pa and high-performance microphone applications.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Valine metabolism disruption is linked to heart disease, but the mechanisms are unclear. Here, the authors show that ACAD8 deficiency drives isobutyryl-CoA accumulation and histone isobutyrylation, increasing chromatin accessibility and gene expression to promote cardiac hypertrophy, while ACAD8 overexpression reverses these effects.

Acute severe ulcerative colitis lacks effective therapies. Here, the authors show that PIAS1-mediated SUMO1 modification of RIPK1 drives necroptosis via phase separation and develops a synergistic therapy of necroptosis blockade and organoid transplantation.

Self-healing materials typically suffer from poor mechanical properties due to the inherent trade-off between mechanical robustness and self-healing capability. Here the authors report a composite featuring an aligned array of hydroxyapatite nanowires interwoven with dynamic borate bond networks by a bidirectional freeze-drying method.

Nonreciprocal magneto-transport is often attributed to Zeeman-driven mechanisms. Here, the authors identify Lorentz skew scattering nonreciprocal magneto-transport in BiTeBr which emerges from the cooperation of classical Lorentz force and quantum skew scattering.

The lack of hormone-responsive follicles is a major challenge in treating infertility related to premature ovarian insufficiency and diminished ovarian reserve. Here, the authors show that intraovarian securinine injection promotes small follicle development in aged mice and cynomolgus macaques by modulating stromal–granulosa signaling.

The authors establish high-resolution spatiotemporal landscapes of AKI. They reveal that surviving epithelial cells are the primary drivers of kidney regeneration through proliferation, offering insights into the mechanism of kidney repair after AKI

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Decoding skin gases can reveal a lot about our health. Here, the authors introduce a monolithic AI-powered wearable ring designed to non-invasively monitor dermal volatile-organic-compounds associated with diet-related metabolism.

Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

This study highlights a strategy to additively manufacture lightweight, strong, and ductile heat-resistant aluminum alloys. The partial solid-state amorphization of the nanoprecipitates during high-temperature tension offers an additional toughening mechanism.

Liquid–liquid phase separation organizes cellular signaling, but its role in antiviral RNA sensing remains to be further explored. The authors here show that CSDE1 forms condensates that sequester viral RNA and exclude RIG-I to suppress immunity, while targeting CSDE1 condensation suppresses viral replication.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

This study shows that the EBF2 activates brown fat through biomolecular condensation. Disrupting EBF2 condensates impairs thermogenic gene expression, while small molecules that modulate condensate dynamics improve thermogenic programming.

Authors reveal symmetry-protected topological phonons and strong phonon interactions in the thermoelectric Mg₃Bi_2-xSb_x family, explaining its low thermal conductivity and offering a strategy to engineer heat flow in thermoelectric materials.

To directly examine how burst-suppression emerges across large neuronal populations, here authors present a Cortex-wide Optical-electrical Dual-modal Explorer (CODE) system. This integrated optical–electrical recording system reveals how large-scale neuronal ensembles organize burst and suppression activity across the mouse cortex during anesthesia, uncovering coordinated dynamics underlying cortical state transitions.

The authors report associations of social isolations and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioral phenotypes among UK Biobank participants.

Cell fate decisions during early embryonic development require precise regulatory control. Here, the authors show that m6A RNA modification regulates primitive endoderm differentiation by modulating the stability of key transcripts during the second cell fate decision in mouse embryos.

The treatment and diagnosis of rheumatoid arthritis (RA) remain challenging. Here, the authors use a collagen-hybridizing peptide specific for damaged collagen, allowing both therapeutic targeting and imaging of inflamed joints in a mouse model of RA.

Developing efficient battery electrolytes is a slow and complex challenge. Here, authors create a deep active learning framework that rapidly identifies high-performance materials and transfers knowledge to new designs, tripling battery lifespan while requiring significantly fewer experiments.

RNA-binding proteins (RBPs) regulate gene expression, but predicting RBP–RNA interactions across species is challenging. Here, the authors introduce MuSIC, a deep learning framework leveraging label smoothing and evolutionary conservation across 11 species to predict cross-species RBP–RNA interactions.

Hong Kong experienced a severe wave of SARS-CoV-2 in early 2022. Here, the authors use genomic and serosurveillance data and show that this wave was dominated by the Omicron BA.2 sublineage, and that low protective immunity, particularly in older age groups, contributed to its severity.

Microplastics were detected in half of the intestinal tumours sampled, and patients with microplastic-positive tumours showed considerably higher tumour recurrence rates and elevated gastrointestinal symptom severity over 34 months of follow-up.

Microcavity exciton polaritons are a promising platform for optical parametric processes. Here, authors achieve efficient parametric emission with strong phase coherence in quantum confined microcavities, demonstrating a polariton supersolid phase at room temperature.

Microbial biosynthesis of monoterpene esters remains a major challenge due to the limited repertoire of highly selective alcohol acyltransferases (AATs). Here the authors discovered and engineered AATs for various monoterpene esters using a dual-substrate microbial platform.

Here the authors reveal a large-scale multi-ancestry genome-wide association study (GWAS) that identifies 11 new risk loci for kidney cancer, including one specific to Chinese populations.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Current artificial vision systems suffer from high energy consumption and latency due to the von Neumann bottleneck and separated spatiotemporal processing. Wu et al. propose a vision system achieving native spatiotemporal co-processing with millisecond latency and 95% action recognition accuracy at low computational cost.

Synthetic DNA guides (crDNA) reprogram Cas12a nucleases for RNA targeting.

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8⁺ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.

Tight regulation of thymic T cell development is critical for immune homeostasis and leukemia prevention. Here, the authors identify USP10 as a MYC-induced deubiquitinase stabilizing SOX4 in early T cell development and T-cell acute lymphoblastic leukemia progression, while USP10 inhibition delays leukemogenesis in mice.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Superionic conductors are typically engineered from static crystal structures. Here, authors present how flexible polyanion rotations induce dynamic disorder in lithium sublattice, enabling liquid-like ion diffusion and enhanced ionic conductivity.

Quantum gravity theories predict a Generalized Uncertainty Principle (GUP) that modifies quantum mechanics at the Planck scale. The authors propose an optomechanical scheme based on interference to measure the GUP, with resolution unconstrained by the oscillator quality factor and expected to detect signals ten orders of magnitude below the electroweak scale under current experimental conditions.

How magnetic impurities influence superconductivity and electronic order in kagome metals remains unclear. Now anisotropic Kondo resonances intertwined with the superconducting gap are observed in a magnetically doped kagome superconductor.

This study reveals that enhanced autophagy in root-hair-forming cells helps Arabidopsis store excess sodium, control oxidative stress and tolerate salt stress.