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Scientific Reports (17)
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Showing 1–50 of 54 results

Advanced filters: Author: Hongquan Li Clear advanced filters

Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation

Metabolic syndrome (MS) is associated with enhanced risk to develop endometrial cancer (EC). Here, the authors show that oleic acid, increased in MS, promotes endometrial cancer by supporting the stability of the rate-limiting enzyme in polyamine metabolism ODC1 and polyamine accumulation.

Lirong Zhai
Yuan Cheng
Jianliu Wang
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 17, P: 1-22
CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription

DDX41 is thought to act solely as a tumor suppressor or DNA virus sensor. Here, the authors uncover DDX41’s oncogenic role in liver cancer, linking it to R-loop processing, ribosome biogenesis, and protein synthesis, extending DDX41’s relevance beyond myeloid neoplasms and viral sensing.

Hongquan Li
Yifei He
Xianghuo He
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-18
IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation

Lai and colleagues show that the RNA helicase DDX5 mediates the alternative splicing of the IL-36R mRNA in keratinocytes and modulates skin inflammation downstream of IL-17D signaling.

Xinhui Ni
Yi Xu
Yuping Lai
ResearchOpen Access21 Oct 2022
Nature Immunology

Volume: 23, P: 1577-1587
The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain

The neuraminidase antigenicity of the circulating influenza A(H3N2) viruses differs from that of a recent A(H3N2) vaccine virus due to three amino acid substitutions, two of which introduce an N-linked glycosylation site that significantly reduces the binding of neuraminidase by antibodies.

Hongquan Wan
Jin Gao
Zhiping Ye
Research12 Aug 2019
Nature Microbiology

Volume: 4, P: 2216-2225
Single cell profiling of primary and paired metastatic lymph node tumors in breast cancer patients

Lymph node metastasized tumours (LNMT) in breast cancer have not been comprehensively characterised. Here, the authors perform single cell RNA sequencing analysis of paired primary and LNMT breast cancer samples and suggest a more immunosuppressive tumour microenvironment in the latter.

Tong Liu
Cheng Liu
Hongquan Zhang
ResearchOpen Access10 Nov 2022
Nature Communications

Volume: 13, P: 1-17
Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid

Isoniazid (INH) is an anti-tuberculosis drug; however the underlying cause of its various side effects are not understood. Here the authors identified lysine isonicotinylation as a histone modification on chromatin that is metabolically regulated by INH and its metabolites.

Yuhan Jiang
Yixiao Li
Hongquan Zhang
ResearchOpen Access20 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Multichrome encoding-based multiplexed, spatially resolved imaging reveals single-cell RNA epigenetic modifications heterogeneity

Understanding the heterogeneity of epigenetic modifications is pivotal for unraveling cellular functions. Here, the authors developed a strategy based on multichrome encoding and “AND” Boolean logic recognition, termed as PREEM, for multiplexed imaging of m6A modifications of single-cell RNA.

Dongsheng Mao
Xiaochen Tang
Xiaoli Zhu
ResearchOpen Access22 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Efficacy of progesterone for moderate to severe traumatic brain injury: a meta-analysis of randomized clinical trials

Chao Lin
Hongquan He
Ning Liu
ResearchOpen Access25 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
Correction: The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21

Yifei He
Hongquan Li
Xianghuo He
Amendments and CorrectionsOpen Access06 May 2025
Cell Death & Disease

Volume: 16, P: 1-2
APOBEC3 induces mutations during repair of CRISPR–Cas9-generated DNA breaks

The APOBEC-AID family of cytidine deaminases target single-stranded nucleic acids for cytidine-to-uridine deamination and can thereby affect DNA repair processes that occur during CRISPR–Cas9-mediated genome editing.

Liqun Lei
Hongquan Chen
Jia Chen
Research11 Dec 2017
Nature Structural & Molecular Biology

Volume: 25, P: 45-52
A microRNA-initiated DNAzyme motor operating in living cells

Synthetic DNA nanomachines have been designed to perform a variety of tasksin vitro. Here, the authors build a nanomotor system that integrates a DNAzyme and DNA track on a gold nanoparticle, to facilitate cellular uptake, and apply it as a real-time miRNA imaging tool in living cells.

Hanyong Peng
Xing-Fang Li
X. Chris Le
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-13
The enhanced cytotoxicity on breast cancer cells by Tanshinone I-induced photodynamic effect

Chen Fengchao
Zhang Siya
Li Kun
ResearchOpen Access23 Oct 2023
Scientific Reports

Volume: 13, P: 1-11
In vitro SELEX and application of an African swine fever virus (ASFV) p30 protein specific aptamer

Changchun Hu
Shuo Li
Yan Deng
ResearchOpen Access19 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21

Yifei He
Hongquan Li
Xianghuo He
ResearchOpen Access14 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-15
Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes

Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.

Yelin Wu
Yanchun Quan
Yuping Lai
ResearchOpen Access10 Nov 2016
Nature Communications

Volume: 7, P: 1-14
Comparative Analysis of VOCs in Exhaled Breath of Amyotrophic Lateral Sclerosis and Cervical Spondylotic Myelopathy Patients

Changsong Wang
Mingjuan Li
Enyou Li
ResearchOpen Access23 May 2016
Scientific Reports

Volume: 6, P: 1-7
Lightweight aerial image object detection algorithm based on improved YOLOv5s

Lixia Deng
Lingyun Bi
Haiying Liu
ResearchOpen Access15 May 2023
Scientific Reports

Volume: 13, P: 1-10
A microfluidic platform for highly parallel bite by bite profiling of mosquito-borne pathogen transmission

High-throughput molecular surveillance of mosquitoes carrying dangerous pathogens is currently challenging. Here the authors present Vectorchip, a low-cost microfluidic platform enabling multiplexed detection of mosquito DNA, viral RNA and infectious viral particles at single bite resolution.

Shailabh Kumar
Felix J. H. Hol
Manu Prakash
ResearchOpen Access14 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Scale-free vertical tracking microscopy

Scale-free vertical tracking microscopy based on a ‘hydrodynamic treadmill’ enables measuring long-range movements of freely suspended organisms with high spatiotemporal resolution.

Deepak Krishnamurthy
Hongquan Li
Manu Prakash
Research17 Aug 2020
Nature Methods

Volume: 17, P: 1040-1051
KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid accumulation in pancreatic ductal adenocarcinoma

Yumin Wang
Shiqian Liu
Hongquan Wang
ResearchOpen Access24 May 2024
Cell Death Discovery

Volume: 10, P: 1-14
The significance of glycemic variability in conjunction with lactate metabolism levels in the clinical assessment of neonatal hypoxic-ischemic encephalopathy

Lili Zhang
Chuanhua Wang
Lijun Jiang
ResearchOpen Access08 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

A group of neutralizing monoclonal antibodies (mAbs) targeting the influenza A hemagglutinin has been selected and characterized. Remarkably, these mAbs were able to neutralize a broad array of group 1 strains and could protect mice from infection when given prophylactically or therapeutically. The crystal structure of one such mAb in complex with hemagglutinin provides insight into its mechanism of neutralization and broad specificity.

Jianhua Sui
William C Hwang
Wayne A Marasco
Research22 Feb 2009
Nature Structural & Molecular Biology

Volume: 16, P: 265-273
Towards explicit regulating-ion-transport: nanochannels with only function-elements at outer-surface

Function elements are key components for nanochannel systems for artificial regulation of ion transport. Here, the authors investigate the independent role of function elements at the outer surface of nanochannel systems, without function elements at inner walls, in promoting osmotic energy conversion and biochemical sensing.

Qun Ma
Yu Li
Fan Xia
ResearchOpen Access10 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Ultralong well-aligned TiO₂:Ln³⁺ (Ln = Eu, Sm, or Er) fibres prepared by modified electrospinning and their temperature-dependent luminescence

Hongquan Yu
Yue Li
Baojiu Chen
ResearchOpen Access07 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Reproducible Ultrahigh SERS Enhancement in Single Deterministic Hotspots Using Nanosphere-Plane Antennas Under Radially Polarized Excitation

Jing Long
Hui Yi
Tian Yang
ResearchOpen Access13 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
The immune adherence receptor CR1-like existed on porcine erythrocytes membrane

Wei Yin
Jiaoyan Cui
Hongquan Li
ResearchOpen Access13 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
Dual base editor catalyzes both cytosine and adenine base conversions in human cells

Base editors that modify both adenine and cytosine broaden the potential applications of base editing.

Xiaohui Zhang
Biyun Zhu
Dali Li
Research01 Jun 2020
Nature Biotechnology

Volume: 38, P: 856-860
Isovolumic relaxation intraventricular pressure difference predicts elevated left ventricular end-diastolic pressure in patients with coronary artery disease

Hongquan Lu
Fujian Duan
Hui Li
ResearchOpen Access13 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Myosin-X provides a motor-based link between integrins and the cytoskeleton

Hongquan Zhang
Jonathan S. Berg
Staffan Strömblad
Research23 May 2004
Nature Cell Biology

Volume: 6, P: 523-531
Donor liver natural killer cells ameliorate liver allograft rejection via inducing apoptosis of alloreactive CD8⁺ T cells generating CD4⁺CD25⁺ regulatory T cells

Jiandong Yu
Jiayan Wu
Yunle Wan
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Author Correction: Emergent topological states via digital (001) oxide superlattices

Zhiwei Liu
Hongquan Liu
Hanghui Chen
Amendments and CorrectionsOpen Access17 Jun 2024
npj Computational Materials

Volume: 10, P: 1
Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice

Xiaochun Chi
Weiwei Luo
Hongquan Zhang
ResearchOpen Access11 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-16
Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland

Zhenbin Wang
Lei Zhang
Hongquan Zhang
ResearchOpen Access13 Oct 2023
Cell Death & Disease

Volume: 14, P: 1-17
Exosomes derived from endothelial progenitor cells ameliorate LPS-induced brain microvascular endothelial cells injury by delivering miR-126a-5p

Hongquan Zhang
Caiyun Lu
Baohui Jia
ResearchOpen Access09 Aug 2024
Scientific Reports

Volume: 14, P: 1-10
An immune gene signature to predict prognosis and immunotherapeutic response in lung adenocarcinoma

Hongquan Chen
Renxi Lin
Yuanlin Qi
ResearchOpen Access17 May 2022
Scientific Reports

Volume: 12, P: 1-20
Emergent topological states via digital (001) oxide superlattices

Zhiwei Liu
Hongquan Liu
Hanghui Chen
ResearchOpen Access29 Sept 2022
npj Computational Materials

Volume: 8, P: 1-12
Near infrared emissions from both high efficient quantum cutting (173%) and nearly-pure-color upconversion in NaY(WO₄)₂:Er³⁺/Yb³⁺ with thermal management capability for silicon-based solar cells

The Yb³⁺ emissions from both the quantum cutting and nearly-pure infrared upconversion and excellent temperature detection were realized in Er³⁺/Yb³⁺ co-doped NaY(WO₄)₂ phosphors.

Duan Gao
Baojiu Chen
Lihong Cheng
ResearchOpen Access16 Jan 2024
Light: Science & Applications

Volume: 13, P: 1-14
Regional and functional division of functional elements of solid-state nanochannels for enhanced sensitivity and specificity of biosensing in complex matrices

This protocol enables explicit regional and functional division of functional elements of solid-state nanochannels to improve the sensitivity and specificity of bioanalysis in complex matrices.

Pengcheng Gao
Dagui Wang
Fan Xia
Protocols28 Jul 2021
Nature Protocols

Volume: 16, P: 4201-4226
Inhibitory effect and mechanism of Tagetes erecta L. fungicide on Fusarium oxysporum f. sp. niveum

Ruochen Du
Jiandong Liu
Jinsheng Wang
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-13
Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells

Xiaoran Li
Jie Lu
Zhenhe Suo
ResearchOpen Access11 Jul 2017
Scientific Reports

Volume: 7, P: 1-20
Cell graph neural networks enable the precise prediction of patient survival in gastric cancer

Yanan Wang
Yu Guang Wang
Jiangning Song
ResearchOpen Access23 Jun 2022
npj Precision Oncology

Volume: 6, P: 1-12
A lightweight YOLOv3 algorithm used for safety helmet detection

Lixia Deng
Hongquan Li
Jason Gu
ResearchOpen Access29 Jun 2022
Scientific Reports

Volume: 12, P: 1-15
p53-dependent elimination of aneuploid mitotic offspring by entosis

Jianqing Liang
Zubiao Niu
Qiang Sun
Research27 Oct 2020
Cell Death & Differentiation

Volume: 28, P: 799-813
Antigenic comparison of the neuraminidases from recent influenza A vaccine viruses and 2019–2020 circulating strains

Jin Gao
Xing Li
Robert Daniels
ResearchOpen Access14 Jul 2022
npj Vaccines

Volume: 7, P: 1-11
M2-like tumor-associated macrophages transmit exosomal miR-27b-3p and maintain glioblastoma stem-like cell properties

Guifang Zhao
Lijuan Ding
Ling Qi
ResearchOpen Access04 Aug 2022
Cell Death Discovery

Volume: 8, P: 1-10
microRNA-27a-3p delivered by extracellular vesicles from glioblastoma cells induces M2 macrophage polarization via the EZH1/KDM3A/CTGF axis

Guifang Zhao
Hongquan Yu
Ling Qi
ResearchOpen Access14 May 2022
Cell Death Discovery

Volume: 8, P: 1-12
Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK

Sen Li
Yan Zhang
Ting Wang
ResearchOpen Access07 Oct 2019
Nutrition & Diabetes

Volume: 9, P: 1-10
Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

Pengfei Xu
Xiaohao Zhang
Gelin Xu
ResearchOpen Access19 Jul 2019
Cell Death & Disease

Volume: 10, P: 1-17
Microscopy with microfluidics in microgravity using FlightScope

Thomas Wareing
Alexander Stokes
Adam J. M. Wollman
ResearchOpen Access06 May 2025
npj Microgravity

Volume: 11, P: 1-8
Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2

Na Sun
Panpan Sun
Hongquan Li
ResearchOpen Access15 Apr 2016
Scientific Reports

Volume: 6, P: 1-13

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