Nature Search

Risperidone reduces individualized morphometric similarity deviation in schizophrenia and associates with cortical transcriptomic patterns

Liju Liu
Mi Yang
Xiangyang Zhang
ResearchOpen Access10 Jan 2026
Schizophrenia

P: 1-13
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.

Huafu Li
Linxiang Lan
Axel Behrens
ResearchOpen Access24 Sept 2025
Nature

Volume: 648, P: 203-209
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.

Hengxing Chen
Yun Li
Changhua Zhang
ResearchOpen Access03 Jul 2024
Nature

Volume: 631, P: 663-669
Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia

Compressed organizational axis of cortical thickness in early-onset schizophrenia reveals a systematic disturbance of maturational processes and supports the neurodevelopmental hypothesis of schizophrenia.

Yun-Shuang Fan
Yong Xu
Huafu Chen
ResearchOpen Access21 May 2025
Communications Biology

Volume: 8, P: 1-9
NLRP3-mediated trained immunity of microglia is involved in the recurrence-like episode of depressive disorders

Gaojie Xu
Minlan Yuan
Zili You
Research18 Nov 2025
Molecular Psychiatry

P: 1-12
Major depressive disorder on a neuromorphic continuum

Li et al. identify three latent patterns of brain abnormalities in MDD using an unsupervised machine learning technique, and quantify their expression level for each patient.

Jiao Li
Zhiliang Long
Wei Liao
ResearchOpen Access11 Mar 2025
Nature Communications

Volume: 16, P: 1-13
Diffusion trajectory of atypical morphological development in autism spectrum disorder

Using Kullback–Leibler divergence to analyze distribution deviations in brain morphology between ASDs and TDCs, this study reveals a shift from gray matter overgrowth to delayed maturation, with atypically developing regions constrained by intrinsic functional networks.

Yu Feng
Weixing Zhao
Xujun Duan
ResearchOpen Access16 Oct 2025
Communications Biology

Volume: 8, P: 1-12
Parsing altered gray matter morphology of depression using a framework integrating the normative model and non-negative matrix factorization

The neuroanatomical heterogeneity of depression is not well understood. Here, the authors identify four latent factors which characterise different patterns of gray matter morphology and are related to clinical symptoms.

Shaoqiang Han
Qian Cui
Yong Zhang
ResearchOpen Access08 Jul 2023
Nature Communications

Volume: 14, P: 1-10
Decomposing cortical activity through neuronal tracing connectome-eigenmodes in marmosets

The relationship between neuroanatomical connections and functional activity is still unclear. Using graph signal processing, the authors show neuronal tracing connectome eigenmodes constrain cortical activity in marmosets.

Jie Xia
Cirong Liu
Wei Liao
ResearchOpen Access13 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations

Yun-Shuang Fan
Yong Xu
Huafu Chen
Research28 Aug 2025
Molecular Psychiatry

Volume: 31, P: 929-940
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures

The correlation between brain structural changes in major depressive disorder (MDD) and gene expression is unclear. Here, the authors explore the correlation between cell type-specific gene expression changes and cortical structural difference in individuals with major depressive disorder.

Jiao Li
Jakob Seidlitz
Wei Liao
ResearchOpen Access12 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Progressive brain structural alterations assessed via causal analysis in patients with generalized anxiety disorder

Yuyan Chen
Qian Cui
Huafu Chen
Research12 May 2020
Neuropsychopharmacology

Volume: 45, P: 1689-1697
Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders

Shared neuroanatomical differential factors explain heterogeneous gray matter volume variations in five common psychiatric disorders. These factors are characterized by dissociable cognitive processes, molecular signatures, and connectome-informed epicenters.

Shaoqiang Han
Ya Tian
Yong Zhang
ResearchOpen Access14 Feb 2025
Communications Biology

Volume: 8, P: 1-15
Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson’s disease

Xinmin Hou
Kai Zhou
Qing Gao
ResearchOpen Access28 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Brain structural features with functional priori to classify Parkinson’s disease and multiple system atrophy using diagnostic MRI

Kai Zhou
Jie Li
Qing Gao
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Neural encoding with unsupervised spiking convolutional neural network

Unsupervised spiking convolutional neural networks (SCNNs) exhibit improved performance to object-optimized CNNs in predicting fMRI responses induced by visual stimuli and achieve promising results on image identification and reconstruction tasks.

Chong Wang
Hongmei Yan
Huafu Chen
ResearchOpen Access28 Aug 2023
Communications Biology

Volume: 6, P: 1-11
Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis

Xiqin Liu
Benjamin Klugah-Brown
Benjamin Becker
ResearchOpen Access23 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-19
Antagonistic network signature of motor function in Parkinson’s disease revealed by connectome-based predictive modeling

Xuyang Wang
Kwangsun Yoo
Rong Li
ResearchOpen Access22 Apr 2022
npj Parkinson's Disease

Volume: 8, P: 1-13
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

Xue-Ru Fan
Ye He
Xi-Nian Zuo
ResearchOpen Access05 Aug 2025
Communications Biology

Volume: 8, P: 1-16
Correction: Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia

Xiangyang Zhang
Mi Yang
Huafu Chen
Amendments and Corrections22 Oct 2019
Molecular Psychiatry

Volume: 25, P: 3454
Differential contributions of subregions of medial temporal lobe to memory system in amnestic mild cognitive impairment: insights from fMRI study

Jiu Chen
Xujun Duan
Zhijun Zhang
ResearchOpen Access17 May 2016
Scientific Reports

Volume: 6, P: 1-14
Chemoarchitectural signatures of subcortical shape alterations in generalized epilepsy

Genetic generalized epilepsies (GGE)exhibited widespread shape alterations in subcortical structures and these morphological anomalies linked to specific neurotransmitter profiles

Yao Meng
Jinming Xiao
Wei Liao
ResearchOpen Access20 Aug 2024
Communications Biology

Volume: 7, P: 1-8
Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response

Mi Yang
Liju Liu
Xiangyang Zhang
ResearchOpen Access04 Jul 2023
Schizophrenia

Volume: 9, P: 1-8
Divergent suicidal symptomatic activations converge on somato-cognitive action network in depression

Jiao Li
Dajing Wang
Wei Liao
ResearchOpen Access14 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1980-1989
Macroscale intrinsic dynamics are associated with microcircuit function in focal and generalized epilepsies

An fMRI study suggests that epilepsy-related perturbations of spontaneous brain activity affect macroscale intrinsic dynamics and microcircuit organizations, and that they are highly spatially correlated.

Siqi Yang
Yimin Zhou
Zhiqiang Zhang
ResearchOpen Access01 Feb 2024
Communications Biology

Volume: 7, P: 1-12
Correction: Individual-specific functional connectivity markers track dimensional and categorical features of psychotic illness

Danhong Wang
Meiling Li
Hesheng Liu
Amendments and Corrections16 Jan 2019
Molecular Psychiatry

Volume: 25, P: 2200
Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia

Xiangyang Zhang
Mi Yang
Huafu Chen
Research13 Aug 2019
Molecular Psychiatry

Volume: 25, P: 3220-3230
White-matter functional topology: a neuromarker for classification and prediction in unmedicated depression

Jiao Li
Heng Chen
Wei Liao
ResearchOpen Access30 Oct 2020
Translational Psychiatry

Volume: 10, P: 1-10
Correction: Corrigendum: Mapping the small-world properties of brain networks in deception with functional near-infrared spectroscopy

Jiang Zhang
Xiaohong Lin
Zhen Yuan
Amendments and CorrectionsOpen Access31 May 2016
Scientific Reports

Volume: 6, P: 1
Atypical developmental trajectory of local spontaneous brain activity in autism spectrum disorder

Xiaonan Guo
Heng Chen
Huafu Chen
ResearchOpen Access06 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Investigation of the Changes in the Power Distribution in Resting-State Brain Networks Associated with Pure Conduct Disorder

Jiang Zhang
Jiansong Zhou
Zhen Yuan
ResearchOpen Access17 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Extraversion and neuroticism related to the resting-state effective connectivity of amygdala

Yajing Pang
Qian Cui
Huafu Chen
ResearchOpen Access21 Oct 2016
Scientific Reports

Volume: 6, P: 1-9
Cortical gradient of a human functional similarity network captured by the geometry of cytoarchitectonic organization

Analysis of functional MRI data from the Human Connectome Project reveals the presence of a cortical gradient, which reflects functional topology and links the macroscale functional landscape with mesoscale laminar differentiation principles.

Yao Meng
Siqi Yang
Wei Liao
ResearchOpen Access30 Oct 2022
Communications Biology

Volume: 5, P: 1-9
Remaining useful life prediction of lithium-ion batteries using a novel particle flow filter framework with grey model

Wang Shuai
Li Yiting
Michael Pecht
ResearchOpen Access26 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter

Jiao Li et al. evaluate the genetic basis underlying white matter functional connectivity variabilities in healthy human subjects. Their results shed light on how transcriptomic and cellular signatures converge to relate to macroscale brain specialization.

Jiao Li
Guo-Rong Wu
Wei Liao
ResearchOpen Access20 Dec 2021
Communications Biology

Volume: 4, P: 1-14
Individual-specific functional connectivity markers track dimensional and categorical features of psychotic illness

Danhong Wang
Meiling Li
Hesheng Liu
Research15 Nov 2018
Molecular Psychiatry

Volume: 25, P: 2119-2129
A neuromarker of individual general fluid intelligence from the white-matter functional connectome

Jiao Li
Bharat B. Biswal
Wei Liao
ResearchOpen Access13 May 2020
Translational Psychiatry

Volume: 10, P: 1-12
Frequency-dependent circuits anchored in the dorsal and ventral left anterior insula

Yifeng Wang
Qijun Zou
Huafu Chen
ResearchOpen Access05 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
Language lateralization during the Chinese semantic task relates to the contralateral cerebra-cerebellar interactions at rest

Qing Gao
Zhongping Tao
Huafu Chen
ResearchOpen Access25 Oct 2017
Scientific Reports

Volume: 7, P: 1-12
Effect of handedness on brain activity patterns and effective connectivity network during the semantic task of Chinese characters

Qing Gao
Junping Wang
Huafu Chen
ResearchOpen Access15 Dec 2015
Scientific Reports

Volume: 5, P: 1-11
Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures

Rong Li
Yibo Li
Huafu Chen
ResearchOpen Access25 Jun 2015
Scientific Reports

Volume: 5, P: 1-12
Altered Intrinsic Regional Activity and Interregional Functional Connectivity in Post-stroke Aphasia

Mi Yang
Jiao Li
Huafu Chen
ResearchOpen Access19 Apr 2016
Scientific Reports

Volume: 6, P: 1-9
An Investigation of the Differences and Similarities between Generated Small-World Networks for Right- and Left-Hand Motor Imageries

Jiang Zhang
Yuyao Li
Zhen Yuan
ResearchOpen Access04 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
Causal connectivity alterations of cortical-subcortical circuit anchored on reduced hemodynamic response brain regions in first-episode drug-naïve major depressive disorder

Qing Gao
Ke Zou
Huafu Chen
ResearchOpen Access25 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Alteration of functional connectivity in autism spectrum disorder: effect of age and anatomical distance

Zhiliang Long
Xujun Duan
Huafu Chen
ResearchOpen Access19 May 2016
Scientific Reports

Volume: 6, P: 1-8
Mapping the small-world properties of brain networks in deception with functional near-infrared spectroscopy

Jiang Zhang
Xiaohong Lin
Zhen Yuan
ResearchOpen Access29 Apr 2016
Scientific Reports

Volume: 6, P: 1-12
Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study

Yarui Wei
Ziyu Wang
Jingliang Cheng
ReviewsOpen Access22 Jan 2025
Schizophrenia

Volume: 11, P: 1-11

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