Nature Search

MRI of carotid atherosclerosis: clinical implications and future directions

In this Review, the authors discuss the utilization of multiple, high spatial resolution contrast weightings for thein vivoassessment of carotid atherosclerotic disease. Although 'carotid MRI' is presently an established imaging tool dedicated to research, the burgeoning data from prospective studies has placed it at the precipice of translation to clinical practice.

Hunter R. Underhill
Thomas S. Hatsukami
Chun Yuan
Reviews26 Jan 2010
Nature Reviews Cardiology

Volume: 7, P: 165-173
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Reza Asadollahi
Aisha Ahmad
Noa Lipstein
ResearchOpen Access22 Oct 2025
Nature Genetics

Volume: 57, P: 2691-2704
Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer

There is high prevalence of whole genome duplication (WGD) in high grade serous ovarian cancer. Here, the authors compare tumours with and without WGD and find that those that acquired WGD early during tumour evolution are associated with worse survival and have the lowest expression of MHC-II.

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-13
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC.

Olga Kondrashova
Monique Topp
Clare L. Scott
ResearchOpen Access28 Sept 2018
Nature Communications

Volume: 9, P: 1-16
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang
Dane Cheasley
Kylie L. Gorringe
Research28 Jul 2020
Modern Pathology

Volume: 34, P: 194-206
Heterozygous variants that disturb the transcriptional repressor activity of FOXP4 cause a developmental disorder with speech/language delays and multiple congenital abnormalities

Lot Snijders Blok
Arianna Vino
Simon E. Fisher
ResearchOpen Access28 Oct 2020
Genetics in Medicine

Volume: 23, P: 534-542
Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

Nikki L. Burdett
Madelynne O. Willis
Elizabeth L. Christie
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao
Amanda Russell
Anna deFazio
ResearchOpen Access09 May 2014
Scientific Reports

Volume: 4, P: 1-9
Quality of life and quality-adjusted survival (Q-TWiST) in patients receiving dose-intensive or standard dose chemotherapy for high-risk primary breast cancer

J Bernhard
D Zahrieh
A S Coates
ResearchOpen Access27 Nov 2007
British Journal of Cancer

Volume: 98, P: 25-33

Search

MRI of carotid atherosclerosis: clinical implications and future directions

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer

The Somatic Mosaicism across Human Tissues Network

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Heterozygous variants that disturb the transcriptional repressor activity of FOXP4 cause a developmental disorder with speech/language delays and multiple congenital abnormalities

Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Quality of life and quality-adjusted survival (Q-TWiST) in patients receiving dose-intensive or standard dose chemotherapy for high-risk primary breast cancer

Search

Quick links

Search

Filter By:

Search

Quick links