Nature Search

Nitrification rates and ¹⁵N abundances of N₂O and NO₃⁻ in the western North Pacific

Naohiro Yoshida
Hajime Morimoto
Akihiko Hattori
Research28 Dec 1989
Nature

Volume: 342, P: 895-897
Evidence of mature adipocyte proliferation regulated by proliferin

Kazuo Kajita
Ichiro Mori
Tatsuo Ishizuka
ResearchOpen Access28 Jul 2010
Nature Precedings

P: 1
Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations

Miyazaki et al. characterize vepafestinib, a next-generation RET inhibitor that is selective for wild-type RET and solvent front mutants. Due to a unique binding mode, it has enhanced brain penetrance and overcomes resistance to other RET inhibitors.

Isao Miyazaki
Igor Odintsov
Romel Somwar
ResearchOpen Access21 Sept 2023
Nature Cancer

Volume: 4, P: 1345-1361
A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

SARS-CoV-2 Omicron XEC variant, a recombinant of JN.1 progeny, shows increased viral fitness and pathogenicity. Here, the authors show that the nucleocapsid mutation R204P enhances inflammation and suggest a growing role of non-spike mutations in viral evolution.

Shuhei Tsujino
Masumi Tsuda
Miki Kawano
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Geographical cline of allele frequency of group-specific component (GC) in the Japanese populations: An analysis of data obtained by immunoelectrophoresis

Isao Yuasa
Yukio Saneshige
Kichiro Okada
Research01 Dec 1983
Japanese journal of human genetics

Volume: 28, P: 255-261
Author Correction: Vepafestinib is a pharmacologically advanced RET-selective inhibitor with high CNS penetration and inhibitory activity against RET solvent front mutations

Isao Miyazaki
Igor Odintsov
Romel Somwar
Amendments and CorrectionsOpen Access09 Oct 2023
Nature Cancer

Volume: 4, P: 1526
ATP-sensitive K⁺ channel in the mitochondrial inner membrane

Isao Inoue
Hideki Nagase
Tomihiko Higuti
Research18 Jul 1991
Nature

Volume: 352, P: 244-247
Blockage of αβ T-cell development by TCR γδ transgenes

Marc Bonneville
Isao Ishida
Susumu Tonegawa
Research28 Dec 1989
Nature

Volume: 342, P: 931-934
Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

The P681R mutation in the spike protein renders the Delta variant more pathogenic than prototypic SARS-CoV-2 in infected hamsters, and facilitates spike protein cleavage and enhances viral fusogenicity.

Akatsuki Saito
Takashi Irie
Kei Sato
ResearchOpen Access25 Nov 2021
Nature

Volume: 602, P: 300-306
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

XBB.1.5 of SARS-CoV-2 is a descendant of XBB.1 and has mutations in spike and ORF8, making it more infectious to humans. Here, the authors examined in detail the differences in virological properties of the two variants.

Tomokazu Tamura
Takashi Irie
Takasuke Fukuhara
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-17
Essential role for phosphatidylinositol 4,5-bisphosphate in yeast cell proliferation

Isao Uno
Kiyoko Fukami
Tatsuo Ishikawa
Research12 May 1988
Nature

Volume: 333, P: 188-190
Clinical evaluation of a new rapid immunochromatographic test for detection of Bordetella pertussis antigen

Kenji Okada
Yuho Horikoshi
Kazunobu Ouchi
ResearchOpen Access16 May 2022
Scientific Reports

Volume: 12, P: 1-10
Thickness Anomalies in Supported Polystyrene Films with Thicknesses Comparable to the Radius of Gyration

Chunming Yang
Amane Kitahara
Isao Takahashi
Research28 Sept 2009
Polymer Journal

Volume: 41, P: 1036-1040
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

A study of SARS-CoV-2 variants examining their transmission, infectivity, and potential resistance to therapies provides insights into the biology of the Delta variant and its role in the global pandemic.

Petra Mlcochova
Steven A. Kemp
Ravindra K. Gupta
ResearchOpen Access06 Sept 2021
Nature

Volume: 599, P: 114-119
A protein language model for exploring viral fitness landscapes

Ito et al. present CoVFit, an AI model that predicts variant fitness (transmissibility) from spike protein sequences alone. They further demonstrate its utility in forecasting viral evolution via single amino acid mutations.

Jumpei Ito
Adam Strange
Kei Sato
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-16
Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Hisano Yajima
Yuki Anraku
Takao Hashiguchi
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny

Eiji Nagayasu
Myo Pa Pa Thet Hnin Htwe Aung
Haruhiko Maruyama
ResearchOpen Access07 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

A chemical array screen identifies a small-molecule inhibitor of pirin that inhibits its interaction with the oncoprotein Bcl3 and decreases the expression of the tumor mobility protein SNAI2. As a result, the compound perturbs the migration of melanoma cells that have high pirin expression levels.

Isao Miyazaki
Siro Simizu
Hiroyuki Osada
Research15 Aug 2010
Nature Chemical Biology

Volume: 6, P: 667-673
Associations of low carbohydrate diet score with blood pressure levels and hypertension among middle-aged Japanese: the Toon Health Study

Shoaib Aziz
Koutatsu Maruyama
Isao Saito
Research19 Sept 2025
Hypertension Research

Volume: 48, P: 2854-2863
New loci and coding variants confer risk for age-related macular degeneration in East Asians

Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans.

Ching-Yu Cheng
Kenji Yamashiro
Chiea Chuen Khor
ResearchOpen Access28 Jan 2015
Nature Communications

Volume: 6, P: 1-10
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kenya Kusunose
Hisako Yoshida
Mikiko Kagiyama
ResearchOpen Access17 Oct 2021
Hypertension Research

Volume: 45, P: 106-115
Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

An implantable, wirelessly powered optoelectronic device that adheres to tissue for the delivery of low-dose, long-term photodynamic therapy leads to significant antitumour effects in mice with intradermally transplanted tumours.

Kento Yamagishi
Izumi Kirino
Toshinori Fujie
Research16 Jul 2018
Nature Biomedical Engineering

Volume: 3, P: 27-36
Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

In vitro studies in human cell lines and in vivo studies in a hamster model show that the SARS-CoV-2 Omicron variant is less pathogenic than both the Delta variant and an ancestral strain of SARS-CoV-2.

Rigel Suzuki
Daichi Yamasoba
Kei Sato
ResearchOpen Access01 Feb 2022
Nature

Volume: 603, P: 700-705
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development

Akihiro Nishida
Akiko Furukawa
Takahisa Furukawa
Research16 Nov 2003
Nature Neuroscience

Volume: 6, P: 1255-1263
Reclassification prediction of first-year protocol biopsy on active surveillance of prostate cancer by p2PSA-related parameters: from PRIAS-JAPAN

Takuma Kato
Hiromi Hirama
Mikio Sugimoto
Research12 Jul 2021
Prostate Cancer and Prostatic Diseases

Volume: 25, P: 666-671
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

Yuichi Saito
Atsushi Tanaka
Kosuke Nishio
Research14 Nov 2023
Hypertension Research

Volume: 47, P: 168-176
Depth-dependent inhomogeneous characteristics in supported glassy polystyrene films revealed by ultra-low X-ray reflectivity measurements

Long-time measurements on the glass transition of polystyrene thin films supported on Si substrates were performed at various heating rates using X-ray reflectivity. Reconstructed depth profiles of thermal expansivity were obtained by fitting via an integral model, which indicated that the length scale of the interfacial dead region decreases with decreasing heating rate, whereas the thickness of the mobile surface layer increases.

Chunming Yang
Kohei Ishimoto
Isao Takahashi
Research10 Sept 2014
Polymer Journal

Volume: 46, P: 873-879
Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population

Nozomi Yokoyama
Aya Kawasaki
Naoyuki Tsuchiya
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
Author Correction: Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy

Toshihiro Shibutani
Risa Goto
Shuichi Ohkubo
Amendments and CorrectionsOpen Access27 Feb 2024
Scientific Reports

Volume: 14, P: 1-3
Neutralizing immunity against coronaviruses in Tanzanian health care workers

Godfrey Barabona
Isaac Ngare
Takamasa Ueno
ResearchOpen Access06 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Cytomegalovirus Infection of the Central Nervous System Stem Cells from Mouse Embryo: A Model for Developmental Brain Disorders Induced by Cytomegalovirus

Isao Kosugi
Yuichiro Shinmura
Yoshihiro Tsutsui
Research01 Sept 2000
Laboratory Investigation

Volume: 80, P: 1373-1383
Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study

Yuichi Saito
Atsushi Tanaka
Mikiko Kagiyama
ResearchOpen Access05 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

Hiroyuki Muranushi
Takero Shindo
Koji Kato
Research14 Jul 2020
Bone Marrow Transplantation

Volume: 56, P: 155-166
Calboxyvinyl polymer adjuvant enhances respiratory IgA responses through mucosal and systemic administration

Eita Sasaki
Hideki Asanuma
Yoshimasa Takahashi
ResearchOpen Access11 Feb 2025
npj Vaccines

Volume: 10, P: 1-19
A randomized double-blind placebo-controlled trial of an inhibitor of plasminogen activator inhibitor-1 (TM5614) in mild to moderate COVID-19

Toyohiro Hirai
Koichiro Asano
Hideo Harigae
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-11
Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy

Toshihiro Shibutani
Risa Goto
Shuichi Ohkubo
ResearchOpen Access31 May 2023
Scientific Reports

Volume: 13, P: 1-13
Electrocardiogram findings at the initiation of hemodialysis and types of subsequent cardiovascular events

Satoshi Yamaguchi
Takayuki Hamano
Yoshitaka Isaka
Research04 Jan 2021
Hypertension Research

Volume: 44, P: 571-580
Hidden Hypocalcemia as a Risk Factor for Cardiovascular Events and All-Cause Mortality among Patients Undergoing Incident Hemodialysis

Satoshi Yamaguchi
Takayuki Hamano
Yoshitaka Isaka
ResearchOpen Access10 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Non-aqueous, zwitterionic solvent as an alternative for dimethyl sulfoxide in the life sciences

Dimethyl sulfoxide is a commonly used solvent, but its permeability and effect on cells is problematic. Here, an alternative solvent, a zwitterion-type ionic liquid, and its plasma membrane affinity as well as cryo-protecting property and drug-dissolution ability are reported.

Kosuke Kuroda
Tetsuo Komori
Eishu Hirata
ResearchOpen Access11 Nov 2020
Communications Chemistry

Volume: 3, P: 1-7
Outcome of allogeneic hematopoietic stem cell transplantation for follicular lymphoma relapsing after autologous transplantation: analysis of the Japan Society for Hematopoietic Cell Transplantation

Masatoshi Sakurai
Takehiko Mori
Shinobu Tamura
Correspondence29 Jan 2021
Bone Marrow Transplantation

Volume: 56, P: 1462-1466
A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration

Kenji Yamashiro
Keisuke Mori
Nagahisa Yoshimura
ResearchOpen Access23 Aug 2017
Scientific Reports

Volume: 7, P: 1-8
Correction: GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

Hiroyuki Muranushi
Takero Shindo
Koji Kato
Amendments and Corrections25 Aug 2020
Bone Marrow Transplantation

Volume: 56, P: 298

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