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Showing 1–7 of 7 results
Advanced filters: Author: Ivan B. Lomakin Clear advanced filters

  • Computational methods can be used to find potent neutralizing antibodies against viruses such as SARS-CoV-2. Here the authors use an AI method to landscape antibodies, predict specificity and antibody-antigen structure, pick out potent neutralizers and show that these antibodies are protective against SARS-CoV-2 challenge in mice models.

    • Stanislav S. Terekhov
    • Nikita V. Ivanisenko
    • Roger D. Kornberg
    ResearchOpen Access
    Nature Communications
    P: 1-16

  • Three structures of the eukaryotic small ribosomal subunit in complex with initiator tRNA, mRNA and the initiation factors eIF1 and eIF1A have been solved; these structures offer insight into the contributions of the initiation factors, the mechanism by which mRNA is scanned, and the interactions that occur in the ribosome’s P site.

    • Ivan B. Lomakin
    • Thomas A. Steitz
    Research
    Nature
    Volume: 500, P: 307-311

  • Understanding protein synthesis in its cellular context is essential. Here, authors apply in situ cryo-EM to reveal the human ribosome at 2.2 Å resolution, capture 23 states, and uncover drug-specific translation features in native cells.

    • Wei Zheng
    • Yuekang Zhang
    • Yong Xiong
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The human cytoskeleton consists of three major classes of filaments: microfilaments, microtubules and intermediate filaments. Here, we summarize recent progress in deciphering the structure and function of intermediate filaments and their implications for human disease.

    • Ivan B. Lomakin
    • Minh Ho
    • Christopher G. Bunick
    News & Views
    Nature Structural & Molecular Biology
    Volume: 31, P: 849-851