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The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Glaucoma is a common cause of vision loss. Here the authors show that elevated intraocular pressure disrupts the blood retinal barrier (BRB) and contributes to retinal ganglion cell death in mouse glaucoma models, and detect similar BRB disruption in human glaucoma donor eyes.

Response to vagus nerve stimulation cannot currently be predicted, leaving many children to undergo implantation without benefit. We present a deep representation learning model using preoperative T1-weighted MRI to predict treatment response.

Three-dimensional Raman modelling of multiphase inclusions in Sumdo eclogites reveals sulfur rich slab-derived fluids at sub-arc depths, providing direct constraints on deep sulfur cycling and copper mobilization in subduction zones.

Microbial biosynthesis of monoterpene esters remains a major challenge due to the limited repertoire of highly selective alcohol acyltransferases (AATs). Here the authors discovered and engineered AATs for various monoterpene esters using a dual-substrate microbial platform.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

The cellular origin and developmental trajectory of DICER1 syndrome-associated tumors are currently unknown. Here, the authors employ a lineage-traceable genetically modified mouse model for DICER1 syndrome to identify universal fibroblasts as the likely cellular origin of mouse Dicer1 sarcoma and map their developmental trajectory, findings that are validated in human DICER1 mesenchymal tumors.

Midbrain dopamine neurons play a key role in schizophrenia and bipolar disorder. The authors report that altered dopaminergic gene expression in schizophrenia preferentially affects sites with complex chromosomal organization linked to genetic risk.

AlphaFold’s success in protein structure predictions has led to similar attempts to predict interactomes. Here, the authors demonstrate that AI-based screens are very limited in discovering truly novel interactions compared to experimental screens, exposing open challenges in interaction prediction.

Developing efficient battery electrolytes is a slow and complex challenge. Here, authors create a deep active learning framework that rapidly identifies high-performance materials and transfers knowledge to new designs, tripling battery lifespan while requiring significantly fewer experiments.

Microplastic-oil co-contaminants are environmentally concerning, though conventional membranes are typically designed for single pollutant removals. Here the authors design a membrane using a sodium periodate-assisted co-deposition of caffeic acid and ε-polylysine method for the removal of complex mixtures from water.

In this study, the authors show that pulmonary fibroblasts act as dualfunction responders to the human-pathogenic fungus Aspergillus fumigatus, modulating immune responses while safeguarding tissue integrity.

Landform assemblages co-develop with ecosystems to distinguish fundamental permafrost properties across a continental-scale ecoclimate gradient, combining into finer-scale permafrost landsystems that vary with geological and climatic legacies to define predictable consequences of thaw.

Here the authors report that lipidomics analysis of over 13,000 Australians from two cohorts identifies distinct blood lipid signatures linked to habitual dietary exposures. Lipid markers of healthier diets were associated with lower cardiovascular risk and reduced all-cause mortality.

Ribosomal Protein S15 (RPS15) is recurrently mutated in B-cell leukemia but its leukemogenic role remains unclear. Here, the authors establish mutant RPS15 as a cancer driver and reveal mechanisms by which these mutations induce translational defects, DNA damage and genomic instability that together promote leukemogenesis.

The reconstruction and control of supramolecular ropes using minimalist building units remains a fundamental challenge. Here the authors demonstrate self-assembly of cyclo-tryptophan-proline dipeptide stereoisomers into crystalline supramolecular triple-helical structures with tunable S- or Z- twists governed by the configuration of tryptophan residues.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

Using an evolutionary optimization approach, the authors report a culture medium that matures stem cell-derived heart cells, improving their structure, metabolism and electrical activity to advance highly functional models for in vitro testing.

Controlled-source Electromagnetic imaging of the Shumagin Gap shows strong resistivity heterogeneity, with limited fluid volume and low inferred pore pressure along the shallow megathrust, suggesting that structural complexity, not fluid overpressure alone, governs creeping behavior.

This study shows that transcranial ultrasound stimulation can suppress a pathological biomarker in the brain network responsible for symptoms of Parkinson’s disease. This discovery could pave the way for future ultrasound-based deep brain stimulation.

This long-term, large-scale intervention and follow-up MRI study suggests that sustained visceral fat loss, rather than weight loss, is linked to better cognition and attenuation of brain atrophy years later, mainly via improved glycaemic control.

Structural complexity often hinders the efficient conversion of lignin into sustainable high-value products. This bifunctional core–shell catalyst enables a relay reaction that transforms lignin into jet-fuel range cycloalkanes with high yields.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Macrophage-dependent phagocytosis elicits robust antitumor immunity. Nevertheless, therapeutic strategies harnessing phagocytosis have been met with limited success. Here the authors demonstrate that dual-phagocytosis checkpoint blockade, achieved by simultaneously targeting CD47 and CD24, greatly enhances tumor cell phagocytosis thus increasing antigen-presentation capacity, cGAS-STING activation and T cell infiltration into the tumor microenvironment, ultimately fostering robust antitumor immunity in preclinical mouse models of glioblastoma.

Here, the authors show that an Entamoeba histolytica protein, KERP2, binds parasite DNA to regulate virulence genes and then enters human gut cells, disrupting actin and weakening the epithelial barrier during infection.

A single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.

Converting methane into valuable chemicals is challenging due to its stable bonds and inefficient C–C coupling. Herein, a dual-site catalyst with high-valent metals to selectively converts methane to acetic acid with high efficiency and stability.

The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, enabling the inference of syntactic rules for motifs that govern cell-type-specific transcription factor binding and chromatin accessibility during human development.

Emerging multidrug-resistant Neisseria gonorrhoeae is a global health threat in the treatment of gonorrhoea. This study reports the discovery and characterization of a promising antigonorrhoea agent that addresses antibiotic resistance.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

The impact of cooling through the Eocene-Oligocene transition on the marine biosphere is not well constrained. Here the authors construct a high-resolution record of foraminiferal species richness history spanning this transition that reveals differential diversity trends depending on foraminiferal habitat and life mode.

The brain generates high-dimensional representations of complex sensory environments and concurrently predicts expected stimuli. Here the authors show that neural circuits that perform these computations exhibit desegregated representations of sensory stimuli and prediction errors.

Recovery of 48 bat and 9 horse HeV genomes from Australia (2016–2020) identified four Hendra virus clades, offering insights into evolutionary dynamics.

ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration.

Accurate characterization of emerging quantum sensors requires an imaging technique that does not depend on defect-specific optical readout. Here, using a NV center in diamond, the authors detect and map boron vacancy defects in hBN via spin cross-relaxation, enabling quantitative nanoscale imaging and spectroscopy without detecting hBN emission.

Analysis of FeTe films grown using molecular-beam epitaxy and annealed under a Te flux post-growth shows that stoichiometric FeTe is inherently a superconductor, contradicting the long-held view that it is an antiferromagnetic metal.

Synthetic super-enhancers enable specific delivery of anticancer payloads, achieving tumour elimination after a single dose in a mouse model of aggressive glioblastoma.

Dutta et al. demonstrate that the tumor suppressor complex BRCA1–BARD1 physically interacts with the RNA–DNA helicase Senataxin (SETX) and upregulates the activity of SETX to resolve harmful R-loops crucial for the avoidance of transcription–replication conflicts.

This study demonstrates spin–refractive-index locking in a microwave metamaterial, enabling frequency-controlled chiral photon–magnon coupling. This mechanism offers a route toward directional and reconfigurable microwave signal routing.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

This study uses brain recordings, self-reports, and facial analysis to decode acute pain in epilepsy patients. Machine learning reveals stable neural markers in mesolimbic, striatal, and cortical regions, plus facial cues, enabling reliable pain detection in naturalistic settings.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing an experimental framework for the exploration of antigen diversification in Trypanosoma brucei and in other pathogenic microorganisms.

Stable, ultra-low-noise integrated lasers are essential for scalable quantum computers and portable optical clocks. Here, authors demonstrate a chip-scale coil stabilized Brillion laser driving a room-temperature trapped-ion clock and qubit without a bulk reference cavity achieving 99.6% SPAM fidelity.

Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

Alzheimer’s disease-related pathology selectively disrupts those excitatory and inhibitory synapses most coupled to ongoing network activity. At the molecular level, parvalbumin interneurons show earliest signatures of abnormal synaptic processing.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..