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Progressive T cell exhaustion and predominance of aging tissue associated macrophages with advancing disease stage in penile squamous cell carcinoma

Hiroko Miyagi
Xiaoqing Yu
Jad Chahoud
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
The opportunities and barriers for developing tumour-infiltrating lymphocyte therapy for patients with advanced genitourinary cancers

Adoptive cell therapy using tumour-infiltrating lymphocytes (TILs) can enhance immune-based therapies and could be applied to genitourinary cancers. Advances in TIL manufacturing, optimization and delivery methodologies have the potential to improve the safety and efficacy of TIL therapy in the management of advanced genitourinary malignancies. In this Perspective, the authors consider how and why TIL therapy warrants evaluation in clinical trials treating patients with genitourinary cancers.

Marine Potez
Gabriel Roman Souza
Jad Chahoud
Reviews26 Sept 2025
Nature Reviews Urology

P: 1-17
Effective combinatorial immunotherapy for penile squamous cell carcinoma

Penile squamous cell carcinoma (PSCC) is a cancer that is associated with significant mortality. Here, the authors develop a mouse model of PSCC by co-deletion of Smad4 and Apc in the androgen-responsive penile epithelium, and show synergistic efficacy of checkpoint therapy with cabozantinib or celecoxib in their model.

Tianhe Huang
Xi Cheng
Xin Lu
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-15
Immune-based therapies in penile cancer

In this Review, Joshi and colleagues describe the immune landscape of penile cancer, examine existing and novel immune-based therapeutic targets, and discuss the future directions of immune-based therapies in penile cancer based on preclinical and clinical studies.

Vidhu B. Joshi
Philippe E. Spiess
Jad Chahoud
Reviews18 Jul 2022
Nature Reviews Urology

Volume: 19, P: 457-474
Prevalence and biological impact of clinically relevant gene fusions in head and neck cancers

Emily L. Hoskins
Raven Vella
Sameek Roychowdhury
ResearchOpen Access03 Jul 2025
npj Precision Oncology

Volume: 9, P: 1-13
A clinical overview of people living with HIV and genitourinary cancer care

Antiretroviral therapy means that people living with HIV (PLWH) now often have a long life expectancy. However, their risk of developing cancer — most notably virus-related cancers — has been increasing. In this Review, the authors discuss the risk of genitourinary cancers in PLWH, the inequity of health care access and consider how including PLWH in ongoing cancer trials can help to improve cancer care for this population.

Chalairat Suk-Ouichai
Anna E. Coghill
Philippe E. Spiess
Reviews18 Jan 2024
Nature Reviews Urology

Volume: 21, P: 373-383
Understanding genomics and the immune environment of penile cancer to improve therapy

In this Review, Aydin et al. discuss our current knowledge of the genomic, molecular and immunological make-up of penile squamous cell carcinoma and the findings of research studies to explore future therapeutic approaches in this disease.

Ahmet Murat Aydin
Jad Chahoud
Philippe E. Spiess
Reviews18 Aug 2020
Nature Reviews Urology

Volume: 17, P: 555-570

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Progressive T cell exhaustion and predominance of aging tissue associated macrophages with advancing disease stage in penile squamous cell carcinoma

The opportunities and barriers for developing tumour-infiltrating lymphocyte therapy for patients with advanced genitourinary cancers

Effective combinatorial immunotherapy for penile squamous cell carcinoma

Immune-based therapies in penile cancer

Prevalence and biological impact of clinically relevant gene fusions in head and neck cancers

A clinical overview of people living with HIV and genitourinary cancer care

Understanding genomics and the immune environment of penile cancer to improve therapy

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