Di-tert-butylphosphine is an important substituent in many phosphine ligands, however, its heterocyclic analogues have not yet been isolated. Here, the authors report the synthesis and isolation of 2,2,6,6-tetramethylphosphinane on a gram scale starting from ammonium hypophosphite, and its facile use as a building block in ligand construction.
- James D. Nobbs
- Sigit Sugiarto
- Martin van Meurs
