The enantioselective construction of quaternary stereocentres, particularly those with all-carbon substituents, is a challenging problem in asymmetric synthesis. It has now been shown that an alternative retrosynthesis of aldol products provides an opportunity to form such stereocentres with a reaction that creates three new carbon–carbon bonds in a single step.
- Jaya Prakash Das
- Helena Chechik
- Ilan Marek
