Nature Search

The University of California San Diego Post-Treatment Glioblastoma (UCSD-PTGBM) annotated multimodal MRI Dataset

Louis Gagnon
Diviya Gupta
Jeffrey D. Rudie
ResearchOpen Access06 Jan 2026
Scientific Data

P: 1-6
An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy

Genome-wide analysis in individuals of African ancestry identifies a nonsense variant in CD36 associated with increased risk of dilated cardiomyopathy (DCM), partly accounting for the higher incidence of DCM in African-ancestry populations.

Jennifer E. Huffman
Liam Gaziano
Krishna G. Aragam
ResearchOpen Access31 Oct 2025
Nature Genetics

Volume: 57, P: 2682-2690
CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling

Cancer cell motility is necessary for cell invasion and metastasis. Here, the authors identify CNK2 as a key mediator of cancer cell motility, linking extracellular stimuli via AXL signalling and downstream activation of ARF6 GTPase, resulting in increased metastasis in preclinical models.

Guillaume Serwe
David Kachaner
Marc Therrien
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-21
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis

The regulation of the E2F pathway remains incompletely established. Here the authors find that the O-GlcNAcylated FOXK1 associates with the deubiquitinase BAP1 to upregulate transcription of E2F target genes and promote cancer progression.

Oumaima Ahmed
Louis Masclef
El Bachir Affar
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans

Head-to-head comparison of third doses of mRNA COVID-19 vaccines in US Veterans finds that both are effective against documented SARS-CoV-2 infection and severe COVID-19 outcomes.

Barbra A. Dickerman
Hanna Gerlovin
Miguel A. Hernán
Research02 Jan 2023
Nature Microbiology

Volume: 8, P: 55-63
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

REM-sleep behavior disorder often precedes Parkinson’s disease or dementia. Here, the authors perform a genome-wide association study for REM-sleep behavior disorder, and discover how it potentially affects gene expression in the brain.

Lynne Krohn
Karl Heilbron
Ziv Gan-Or
ResearchOpen Access05 Dec 2022
Nature Communications

Volume: 13, P: 1-16
Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH

Vinh Truong
Siying Huang
France Gagnon
ResearchOpen Access11 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.

Usman A. Tahir
Daniel H. Katz
Robert E. Gerszten
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-16
UV LED disinfection as a novel treatment for common salmonid pathogens

Kyle D. Rauch
Jessica L. Bennett
Graham A. Gagnon
ResearchOpen Access18 Nov 2024
Scientific Reports

Volume: 14, P: 1-8
ERK signalling: a master regulator of cell behaviour, life and fate

Extracellular signal-regulated kinase 1 (ERK1) and ERK2 relay cell growth and mitogenic signals to multiple substrates, and thus control essential physiological processes. This Review discusses the regulation of ERKs, and their control of cell proliferation, cell survival, cell growth, cell metabolism, cell migration and cell differentiation.

Hugo Lavoie
Jessica Gagnon
Marc Therrien
Reviews23 Jun 2020
Nature Reviews Molecular Cell Biology

Volume: 21, P: 607-632
Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

Gregor Andelfinger and colleagues identify mutations in SGOL1 that cause a novel cohesinopathy characterized by chronic atrial and intestinal dysrhythmia, termed CAID syndrome. SGOL1 encodes a component of the cohesin complex, suggesting that cardiac and gut rhythm are regulated by this complex.

Philippe Chetaille
Christoph Preuss
Gregor Andelfinger
Research05 Oct 2014
Nature Genetics

Volume: 46, P: 1245-1249
Assessing the impact of multiple ultraviolet disinfection cycles on N95 filtering facepiece respirator integrity

C. Carolina Ontiveros
Crystal L. Sweeney
Graham A. Gagnon
ResearchOpen Access10 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Jorim J. Tielbeek
Emil Uffelmann
Danielle Posthuma
Research25 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4453-4463
Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia

Claudia A Penafuerte
Bruno Gagnon
Michel L Tremblay
ResearchOpen Access08 Mar 2016
British Journal of Cancer

Volume: 114, P: 680-687

Search

The University of California San Diego Post-Treatment Glioblastoma (UCSD-PTGBM) annotated multimodal MRI Dataset

An African ancestry-specific nonsense variant in CD36 is associated with a higher risk of dilated cardiomyopathy

CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling

A second update on mapping the human genetic architecture of COVID-19

O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis

Comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans

Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH

Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

UV LED disinfection as a novel treatment for common salmonid pathogens

ERK signalling: a master regulator of cell behaviour, life and fate

Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm

Assessing the impact of multiple ultraviolet disinfection cycles on N95 filtering facepiece respirator integrity

Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia

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