Nature Search

Z-Calling: a tool for A/Z (2,6-diaminopurine) base calling and dZ-DNA detection using PacBio HiFi reads

Machine learning models using PacBio kinetic signals enable high-sensitivity detection of dZ-DNA and single-nucleotide A/Z base calling to explore the biological roles and biotechnological potential of 2,6-diaminopurine.

Bo Wu
Ying Chen
Chuan-Le Xiao
ResearchOpen Access13 Mar 2026
Communications Biology

P: 1-13
Neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors improves survival from resectable hepatocellular carcinoma in a multicenter, retrospective study (GUIDANCE002)

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

Da-Long Yang
Chuang Qin
Ting Quan
ResearchOpen Access12 Mar 2026
Communications Medicine

Volume: 6, P: 1-11
Topological polarization singular lasing with highly efficient radiation channel

Here the authors develop topological polarization singular lasers that feature paired radiation channels carrying distinct topological properties which leads to single mode lasing with high external quantum efficiency.

Yun-Gang Sang
Jing-Yu Lu
Ren-Min Ma
ResearchOpen Access30 Oct 2022
Nature Communications

Volume: 13, P: 1-6
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Copper-catalysed enantioconvergent O-alkylation of alcohols with racemic α-tertiary haloamides to access enantioenriched hindered dialkyl ethers

The O-alkylation of tertiary alcohols with racemic tertiary electrophiles to access chiral hindered dialkyl ethers has remained elusive. Now this synthetic challenge has been accomplished by copper-catalysed C–O cross-coupling between tertiary haloamides and alcohols using designed ligands.

Jia-Yong Zhang
Ji-Jun Chen
Xin-Yuan Liu
Research28 Aug 2025
Nature Catalysis

Volume: 8, P: 919-930
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Amendments and Corrections11 Mar 2026
Nature Medicine

Volume: 32, P: 1160
Laboratory Study on Disconnection Events in Comets

Yan-Fei Li
Yu-Tong Li
Jie Zhang
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-7
Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines

The chemoselective and enantioconvergent N-alkylation of aliphatic amines, including ammonia, is achieved using chiral tridentate anionic ligands and a copper catalyst; the method shows excellent enantioselectivity and functional-group tolerance.

Ji-Jun Chen
Jia-Heng Fang
Xin-Yuan Liu
Research20 Mar 2023
Nature

Volume: 618, P: 294-300

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