Nature Search

Lifelike agility and play in quadrupedal robots using reinforcement learning and generative pre-trained models

A key challenge in robotics is leveraging pre-training as a form of knowledge to generate movements. The authors propose a general learning framework for reusing pre-trained knowledge across different perception and task levels. The deployed robots exhibit lifelike agility and sophisticated game-playing strategies.

Lei Han
Qingxu Zhu
Zhengyou Zhang
Research05 Jul 2024
Nature Machine Intelligence

Volume: 6, P: 787-798
AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis

Macrocyclization is an important process in bioactive natural product synthesis. Here, the authors report on the study of a macrocyclic ring constructing enzyme in the biosynthesis of alchivemycin A and using gene deletion, biochemical assays and isotope labelling show the enzyme catalyses tandem dehydration and Michael-type addition.

Hong Jie Zhu
Bo Zhang
Hui Ming Ge
ResearchOpen Access03 Aug 2022
Nature Communications

Volume: 13, P: 1-11
Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis

The global regulator PhoP plays crucial roles in bacterial pathogenicity. Shi et al. report four cryo-EM structures of PhoP-dependent transcription activation and repression complexes, revealing dual transcription regulation mechanisms of PhoP.

Jing Shi
Zhenzhen Feng
Wei Lin
ResearchOpen Access13 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Architecture of mammalian respiratory complex I

Complex I is the first enzyme of the mitochondrial electron transport chain and it is essential for oxidative phosphorylation in mammalian mitochondria; here the electron cryo-microscopy structure of complex I from bovine heart mitochondria is reported, advancing knowledge of its structure in mammals.

Kutti R. Vinothkumar
Jiapeng Zhu
Judy Hirst
Research07 Sept 2014
Nature

Volume: 515, P: 80-84
Transforming an ATP-dependent enzyme into a dissipative, self-assembling system

A dissipative self-assembly system was developed by re-engineering a naturally hexameric adenosine 5′-triphosphatase (ATPase) enzyme (filamentous temperature-sensitive protease H) to form transient one-dimensional tubular structures in an ATP-dependent fashion. These tubular structures in turn exert negative feedback on the ATP-dependent activation of the protein building blocks.

Yiying Li
Jie Zhu
F. Akif Tezcan
Research13 Jan 2025
Nature Chemical Biology

Volume: 21, P: 883-893
Comprehensive genomic insights into the genetic causality and comorbidity in urological cancers

Xiangyu Zhang
Feixiang Yang
Jialin Meng
ResearchOpen Access16 Dec 2025
npj Precision Oncology

Volume: 10, P: 1-16
High-resolution in situ structures of mammalian respiratory supercomplexes

Mammalian respiratory supercomplexes are imaged in their native membrane environment by in situ cryo-electron microscopy, providing insight into their reactive intermediates and conformational dynamics.

Wan Zheng
Pengxin Chai
Kai Zhang
ResearchOpen Access29 May 2024
Nature

Volume: 631, P: 232-239
Structures of the CcmABCD heme release complex at multiple states

Bacterial ABC transporter complex CcmABCD, a part of cytochrome c maturation system, transfers heme from one binding partner (CcmC) to another (CcmE). Here authors describe high resolution cryo-EM structures of CcmABCD in multiple states and propose a hypothetic model of heme trafficking, heme transfer and release of holoCcmE.

Jiao Li
Wan Zheng
Jiapeng Zhu
ResearchOpen Access28 Oct 2022
Nature Communications

Volume: 13, P: 1-13
Dynamic behaviors of approximately ellipsoidal microbubbles photothermally generated by a graphene oxide-microheater

Xiaobo Xing
Jiapeng Zheng
Ziyi Chen
ResearchOpen Access15 Aug 2014
Scientific Reports

Volume: 4, P: 1-8
Structure of mammalian respiratory complex I

Electron cryomicroscopy structures are provided for all core and supernumerary protein subunits of mammalian complex I, a 45-subunit enzyme that powers eukaryotic respiration.

Jiapeng Zhu
Kutti R. Vinothkumar
Judy Hirst
Research10 Aug 2016
Nature

Volume: 536, P: 354-358
Preparing a microemulsion-loaded hydrogel for cleaning wall paintings and coins

Jinmeng Zhu
Jiapeng Wang
Xuanhua Li
ResearchOpen Access14 May 2024
Heritage Science

Volume: 12, P: 1-13
Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products

Enzymatic catalysis of pericyclic [6+4] cycloaddition reactions to form ten-membered rings is observed during biosynthesis of the macrocyclic antibiotic streptoseomycin, and the mechanism of these transformations is established.

Bo Zhang
Kai Biao Wang
Hui Ming Ge
Research13 Mar 2019
Nature

Volume: 568, P: 122-126
The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity

Shangkun Zhang
Chaojiang Gu
Tongcun Zhang
ResearchOpen Access21 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression

Weifeng Liang
Ming Gu
Yin Chen
ResearchOpen Access13 Apr 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-4
UWB/MEMS IMU integrated positioning method based on NLOS angle discrimination and MAP constraints

Xin Sui
Jiapeng Song
Zhengxu Shi
ResearchOpen Access27 Aug 2024
Scientific Reports

Volume: 14, P: 1-17
Efficient photon-pair generation in layer-poled lithium niobate nanophotonic waveguides

Electrically creating bi-layer ferroelectric domains in a thin-film lithium niobate waveguide enables high-efficiency second-harmonic generation and photon-pair generation.

Xiaodong Shi
Sakthi Sanjeev Mohanraj
Di Zhu
ResearchOpen Access03 Oct 2024
Light: Science & Applications

Volume: 13, P: 1-10

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Lifelike agility and play in quadrupedal robots using reinforcement learning and generative pre-trained models

AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis

Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis

Architecture of mammalian respiratory complex I

Transforming an ATP-dependent enzyme into a dissipative, self-assembling system

Comprehensive genomic insights into the genetic causality and comorbidity in urological cancers

High-resolution in situ structures of mammalian respiratory supercomplexes

Structures of the CcmABCD heme release complex at multiple states

Dynamic behaviors of approximately ellipsoidal microbubbles photothermally generated by a graphene oxide-microheater

Structure of mammalian respiratory complex I

Preparing a microemulsion-loaded hydrogel for cleaning wall paintings and coins

Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products

The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity

The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression

UWB/MEMS IMU integrated positioning method based on NLOS angle discrimination and MAP constraints

Efficient photon-pair generation in layer-poled lithium niobate nanophotonic waveguides

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