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Functionalization of remote C(sp³)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

Sonogashira cross-coupling is a powerful strategy to prepare functionalized internal alkynes. Here, the authors report a domino sequence for the generation of γ-/δ-alkynyl nitriles and γ-alkynyl ketones from the coupling of terminal alkynes with O-acyloximes derived from cycloalkanones and acylic ketones, respectively.

Zhaodong Li
Rubén O. Torres-Ochoa
Jieping Zhu
ResearchOpen Access21 Jan 2020
Nature Communications

Volume: 11, P: 1-7
Unified divergent strategy towards the total synthesis of the three sub-classes of hasubanan alkaloids

Several Hasubanan alkaloids have been synthesized in the past decades, however a divergent approach to access the 3 subclasses of such natural products has not been reported yet. Here, the authors show the enantioselective total syntheses of four representative members via a unified strategy leading to the three topologically different classes of alkaloids.

Guang Li
Qian Wang
Jieping Zhu
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-7
CRX is an intrinsic suppressor of epithelial‒mesenchymal transition in retinal pigment epithelial cells: a promising therapeutic avenue for subretinal fibrosis

Dongli Li
Qingjian Ou
Haibin Tian
ResearchOpen Access31 Dec 2025
Cell Death & Disease

Volume: 17, P: 1-15
EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress

A new study shows EMP1 protects hematopoietic stem cells by suppressing sphingolipid metabolism and ER stress. EMP1 interacts with CERS2 to limit dihydroceramide production, which causes protein aggregation when elevated.

Lei Li
Yufei Lei
Yu Hou
ResearchOpen Access07 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Generalized biological foundation model with unified nucleic acid and protein language

He and colleagues develop LucaOne, a biological foundation model pre-trained on nucleic acid and protein sequences from 169,861 species. It shows an emerging understanding of molecular biology’s central dogma, enhancing bioinformatics analysis and helping explore unknown aspects of molecular biology.

Yong He
Pan Fang
Zhaorong Li
ResearchOpen Access18 Jun 2025
Nature Machine Intelligence

Volume: 7, P: 942-953
Genome-wide dissection of changes in maize root system architecture during modern breeding

The root-related changes in maize domestication, improvement and modern breeding were systematically investigated, and candidate genes related to maize root system architecture were identified for future genetic improvement.

Wei Ren
Longfei Zhao
Qingchun Pan
Research17 Nov 2022
Nature Plants

Volume: 8, P: 1408-1422
Synthesis and Characterization of Poly(ethylene-co-vinyl alcohol)-graft-poly(ε-caprolactone)

Hongjin Jiang
Junpo He
Yuliang Yang
Research01 Sept 2002
Polymer Journal

Volume: 34, P: 682-686
Crystallization and Morphology Development of Binary Crystalline Poly(ethylene succinate)/Poly(ethylene oxide) (PES/PEO) Blend with Non-Isothermal Crystallization

Shuangai He
Jieping Liu
Research17 Apr 2007
Polymer Journal

Volume: 39, P: 537-542
QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrb^sl mutations

Jieping Huang
Ruihua Dang
Takashi Agui
ResearchOpen Access22 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
A novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells

Huanhuan Qin
Meixi Peng
Yu Hou
ResearchOpen Access05 Jul 2024
Cell Death & Disease

Volume: 15, P: 1-14
Whole genome sequencing identifies pathogenic genetic variants in Han Chinese patients with familial venous thromboembolism

Whole-genome sequencing coupled with whole-exome sequencing validation in Han Chinese patients reveals a diverse genetic basis for venous thromboembolism, and identifies GP6, TET2, and JAK2 as novel risk factors in East Asian populations.

Zhu Zhang
Haobo Li
Chen Wang
ResearchOpen Access12 Apr 2025
Communications Biology

Volume: 8, P: 1-9
Evolutionary diagnosis method for variants in personal exomes

Sudhir Kumar
Maxwell Sanderford
Li Liu
Correspondence30 Aug 2012
Nature Methods

Volume: 9, P: 855-856
Reply to: "Proper reporting of predictor performance"

Sudhir Kumar
Jieping Ye
Li Liu
Correspondence30 Jul 2014
Nature Methods

Volume: 11, P: 781-782
Correction: SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression

Yali Zhang
Yanni Ma
Xi Li
Amendments and CorrectionsOpen Access08 Apr 2025
Cell Death Discovery

Volume: 11, P: 1-4
Combined use of a microbial restoration substrate and avirulent Ralstonia solanacearum for the control of tomato bacterial wilt

Xuefang Zheng
Yujing Zhu
Bo Liu
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

Xiujian Wang
Xiao Tao
He Huang
ResearchOpen Access22 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-19
A Cdh1–FoxM1–Apc axis controls muscle development and regeneration

Zhe Chen
Lei Li
Yu Hou
ResearchOpen Access09 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-16
Association between serum creatinine and type 2 diabetes in the Chinese population: a retrospective cohort study

Rugang Li
Min He
Jieping Huang
ResearchOpen Access26 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Direct conversion of human umbilical cord mesenchymal stem cells into retinal pigment epithelial cells for treatment of retinal degeneration

Xiaoman Zhu
Zhiyang Chen
Haibin Tian
ResearchOpen Access12 Sept 2022
Cell Death & Disease

Volume: 13, P: 1-15
Genetic deconvolution of fetal and maternal cell-free DNA in maternal plasma enables next-generation non-invasive prenatal screening

Chenming Xu
Jianli Li
Jinglan Zhang
ResearchOpen Access13 Oct 2022
Cell Discovery

Volume: 8, P: 1-22
Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites

Rongsong Li
Jieping Yang
Tzung K. Hsiai
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
Genomic architecture of fetal central nervous system anomalies using whole-genome sequencing

Ying Yang
Sheng Zhao
Xinlin Chen
ResearchOpen Access13 May 2022
npj Genomic Medicine

Volume: 7, P: 1-10
Deletion of soluble epoxide hydrolase suppressed chronic kidney disease-related vascular calcification by restoring Sirtuin 3 expression

Wanbing He
Jieping Huang
Hui Huang
ResearchOpen Access23 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-10
A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis

Yeming Yang
Xiao Li
Xianjun Zhu
ResearchOpen Access29 Oct 2021
Cell Death & Disease

Volume: 12, P: 1-15
Effects of a microbial restoration substrate on plant growth and rhizosphere bacterial community in a continuous tomato cropping greenhouse

Xuefang Zheng
Ziran Wang
Bo Liu
ResearchOpen Access13 Aug 2020
Scientific Reports

Volume: 10, P: 1-11
Depletion of Ars2 inhibits cell proliferation and leukemogenesis in acute myeloid leukemia by modulating the miR-6734-3p/p27 axis

Xiaoye Hu
Shuangnian Xu
Ning Gao
ResearchOpen Access05 Dec 2018
Leukemia

Volume: 33, P: 1090-1101
Mechanistic insights into manganese oxidation of a soil-borne Mn(II)-oxidizing Escherichia coli strain by global proteomic and genetic analyses

Zhiyong Wang
Jieping Wang
Lin Li
ResearchOpen Access02 May 2017
Scientific Reports

Volume: 7, P: 1-13
Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity

Si Shi
Huijie Gu
Lixia Lu
ResearchOpen Access01 May 2023
Experimental & Molecular Medicine

Volume: 55, P: 898-909
Effects of donor-specific antibodies on engraftment and long-term survival after allogeneic hematopoietic stem cell transplantation—A systematic review and meta-analysis

Yarui Huang
Chengxin Luo
Shuangnian Xu
Research13 Feb 2023
Bone Marrow Transplantation

Volume: 58, P: 544-551
Cell-autonomous effect of cardiomyocyte branched-chain amino acid catabolism in heart failure in mice

Jia-yu Yu
Nancy Cao
Chen Gao
ResearchOpen Access29 Mar 2023
Acta Pharmacologica Sinica

Volume: 44, P: 1380-1390
Myeloablative conditioning regimens in adult patients with acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation in complete remission: a systematic review and network meta-analysis

Chengxin Luo
Guixian Wu
Shuangnian Xu
Research10 Nov 2022
Bone Marrow Transplantation

Volume: 58, P: 175-185
Small molecules in the treatment of COVID-19

Sibei Lei
Xiaohua Chen
Ke Men
ReviewsOpen Access05 Dec 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-39
SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression

Yali Zhang
Yanni Ma
Xi Li
ResearchOpen Access26 Jul 2021
Cell Death Discovery

Volume: 7, P: 1-10
Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia

Chengfang Zhou
Mei Kuang
Yu Hou
Research11 Oct 2021
Leukemia

Volume: 36, P: 834-846
Efficacy and safety of new anti-CD20 monoclonal antibodies versus rituximab for induction therapy of CD20⁺ B-cell non-Hodgkin lymphomas: a systematic review and meta-analysis

Chengxin Luo
Guixian Wu
Xi Li
ResearchOpen Access05 Feb 2021
Scientific Reports

Volume: 11, P: 1-14
BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity

Wen Jiang
Songjie Feng
Xingxu Huang
Research06 Jun 2018
Cell Research

Volume: 28, P: 855-861
Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial

Susanne M. Henning
Jieping Yang
Zhaoping Li
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
Health benefit of vegetable/fruit juice-based diet: Role of microbiome

Susanne M. Henning
Jieping Yang
Zhaoping Li
ResearchOpen Access19 May 2017
Scientific Reports

Volume: 7, P: 1-9
Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia

Liang Huang
Dan Liu
Qian-fei Wang
Research17 Nov 2017
Cell Research

Volume: 28, P: 172-186

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