Nature Search

Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling

Resistance to immune checkpoint blockade (ICB) is a challenge in hepatocellular carcinoma therapy. Here, the authors show that targeting PRMT3 markedly improves the anticancer efficacy of ICB via interrupting HSP60 methylation and oligomerization, damaging mitochondrial integrity, and thereby activating cGAS/STING-mediated anti-tumor immunity.

Yunxing Shi
Zongfeng Wu
Binkui Li
ResearchOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1-21
A microfluidically controlled concave–convex membrane lens using an addressing operation system

Shouju Yao
Zhou Zhou
Daoheng Sun
ResearchOpen Access18 May 2020
Microsystems & Nanoengineering

Volume: 6, P: 1-9
PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer

Despite being an effective treatment for hepatocellular carcinoma (HCC), resistance to oxaliplatin presents a major obstacle. Here, the authors identify PRMT3-induced methylation of IGF2BP1 resulting in HEG1 stabilisation as a mechanism of oxaliplatin resistance in HCC.

Yunxing Shi
Yi Niu
Binkui Li
ResearchOpen Access06 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance

The bone tumour microenvironment plays an essential role in multiple myeloma (MM) development. Here, the authors show that bone collagen degradation provides glycine to support MM progression through glutathione and purine synthesis.

Jiliang Xia
Jingyu Zhang
Wen Zhou
ResearchOpen Access11 Jul 2022
Nature Communications

Volume: 13, P: 1-16
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

The molecular mechanisms underlying the development of thrombocytopenia in multiple myeloma (MM) remain to be explored. Here, the authors show an association of thrombocytopenia with poor prognosis in MM and identify serine as a key metabolic regulator of thrombocytopenia.

Chunmei Kuang
Meijuan Xia
Wen Zhou
ResearchOpen Access13 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Simultaneous bilateral total knee arthroplasty in patients with end-stage hemophilic arthropathy: a mean follow-up of 6 years

Chao Jiang
Yan Zhao
Xisheng Weng
ResearchOpen Access25 Jan 2018
Scientific Reports

Volume: 8, P: 1-8
Unlocking high photosensitivity direct laser writing and observing atomic clustering in glass

Ag clusters dispersed in glass are critical for optical storage media. The authors present fluorine-modified glass with high Ag⁺ ion solubility, enhancing the formation of Ag clusters under low-energy laser irradiation. The inert network effectively confines Ag clusters uniformly within the glass.

Wenyan Zheng
Zhuo Wang
Xianping Fan
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-10
METTL9-SLC7A11 axis promotes hepatocellular carcinoma progression through ferroptosis inhibition

Fangfang Bi
Yuxiong Qiu
Jiliang Qiu
ResearchOpen Access28 Nov 2023
Cell Death Discovery

Volume: 9, P: 1-11
NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3

Yuanping Zhang
Dinglan Zuo
Binkui Li
ResearchOpen Access04 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-11
Insufficient ablation induces E3-ligase Nedd4 to promote hepatocellular carcinoma progression by tuning TGF-β signaling

Kai Li
Yi Niu
Binkui Li
Research30 Apr 2022
Oncogene

Volume: 41, P: 3197-3209
Continuous electroproduction of formate via CO₂ reduction on local symmetry-broken single-atom catalysts

Atomic-level coordination influences the properties of single-atom-catalysts but is difficult to precisely engineer. Here, authors study the role of local symmetry manipulation, finding planar-symmetry-broken CuN₃ catalysts outperform highly symmetrical CuN₄ for CO₂ electroreduction to formic acid.

Juncai Dong
Yangyang Liu
Shenlong Zhao
ResearchOpen Access27 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Identification breeds equity: the regulation effect of group decision-making on beauty premium

Lu Cheng
Qingguo Ma
Wenwei Qiu
ResearchOpen Access09 May 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-15
Dual frequency sound absorption with an array of shunt loudspeakers

Pengju Zhang
Chaonan Cong
Xiaojun Qiu
ResearchOpen Access02 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Elevator fault diagnosis based on digital twin and PINNs-e-RGCN

Qibing Wang
Luqiang Chen
Jiawei Lu
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-24
Modification of Fe₃O₄ magnetic nanoparticles for antibiotic detection

Min Sun
Xue Bai
YuLou Qiu
ResearchOpen Access08 Feb 2025
Scientific Reports

Volume: 15, P: 1-19
Multiple objectives escaping bird search optimization and its application in stock market prediction based on transformer model

Dedai Wei
Zimo Wang
Kaichen Ouyang
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-51
Unique dynamic mode between Artepillin C and human serum albumin implies the characteristics of Brazilian green propolis representative bioactive component

Fan Wu
Xin-Mi Song
Hong-Liang Li
ResearchOpen Access14 Oct 2020
Scientific Reports

Volume: 10, P: 1-10

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