Several essential brain micro-environments like pH, salt, and metal ions play a vital role in modulating the amyloid-ß fibrillation, however, the cooperative modulation of these variables remains poorly understood. Here, the authors investigate multivariate effects of pH, ionic strength, and Zn2+ ions on Aß40 peptide fibrillation.
- Hongzhi Wang
- Jinming Wu
- Jinghui Luo