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Targeting IP₆ signaling to destabilize homologous recombination proteins to overcome PARP inhibitor resistance

Homologous recombination (HR) safeguards genome stability, but the regulation of HR proteins remains unclear. Here, the authors show that the compound UNI418 inhibits lipid kinases PIKfyve and PIP5K1C, reducing IP6 levels and triggering Cul4A–WDR5 dependent degradation of HR proteins, thereby suppressing HR and overcoming PARP inhibitor resistance.

Seon-gyeong Lee
Yuri Seo
Kyungjae Myung
ResearchOpen Access04 Apr 2026
Nature Communications

P: 1-17
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Amendments and Corrections11 Mar 2026
Nature Medicine

Volume: 32, P: 1160
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

Lee et al. identify SHMT and one-carbon metabolism as a metabolic vulnerability conferred by LKB1 and KEAP1 loss in KRAS-mutant lung cancer.

Hyun Min Lee
Nefertiti Muhammad
Jiyeon Kim
Research14 Jun 2024
Nature Metabolism

Volume: 6, P: 1310-1328
Author Correction: ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells

Jiyeon Lee
Haeryung Lee
Soochul Park
Amendments and CorrectionsOpen Access09 Apr 2024
Nature Communications

Volume: 15, P: 1-2
TMEM145 is a key stereociliary component in the link structures of outer hair cells and mediates the secretion of stereocilin and tubby

The authors identify TMEM145 as a critical protein in cochlear outer hair cells, responsible for linking their stereocilia. Mice lacking TMEM145 develop severe hearing loss at an early age, providing new insights into hearing loss mechanisms.

Jae Won Roh
Kyung Seok Oh
Heon Yung Gee
ResearchOpen Access01 Dec 2025
Nature Communications

Volume: 17, P: 1-17
Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK

SARS-CoV-2 infection has been linked to various persistent or new-onset health consequences, including disruption of the immune system. Here, the authors investigate the risk of new-onset allergic diseases following SARS-CoV-2 infection using data from South Korea, Japan, and the UK.

Jiyeon Oh
Myeongcheol Lee
Dong Keon Yon
ResearchOpen Access02 Apr 2024
Nature Communications

Volume: 15, P: 1-10
ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells

LRP1 plays a key role in the clearance of Aβ peptides across the blood-brain barrier. Here, the authors report that ANKS1A promotes the LRP1-mediated Aβ clearance in brain endothelium, providing insights into the pathology of Alzheimer’s disease.

Jiyeon Lee
Haeryung Lee
Soochul Park
ResearchOpen Access20 Dec 2023
Nature Communications

Volume: 14, P: 1-20
High-performance and stable photoelectrochemical water splitting cell with organic-photoactive-layer-based photoanode

While organic semiconductors may be useful in photoelectrochemical water-splitting materials, they show low stability in water. Here, the authors report high-performance and stable organic-semiconductor-based photoanodes passivated using nickel foils, GaIn eutectic, and layered double hydroxides.

Je Min Yu
Jungho Lee
Ji-Wook Jang
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-9
Surveillance of avian influenza viruses from 2009 to 2013 in South Korea

Jeong-Hyun Nam
Erica Españo
Jeong-Ki Kim
ResearchOpen Access14 Dec 2021
Scientific Reports

Volume: 11, P: 1-7
Breakdown of chiral recognition of amino acids in reduced dimensions

Yongchan Jeong
Hyo Won Kim
Jungpil Seo
ResearchOpen Access30 Sept 2020
Scientific Reports

Volume: 10, P: 1-8
Comparison of ophthalmic toxicity of light-emitting diode and organic light-emitting diode light sources

Ikhyun Jun
Soo Jung Han
Kyoung Yul Seo
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-10
Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway

Jiyeon Seo
Hongik Hwang
Mikyoung Park
ResearchOpen Access25 Nov 2022
Molecular Psychiatry

Volume: 28, P: 1351-1364
Cumulative abdominal obesity exposure and progressive risk of endometrial cancer in young women: a nationwide cohort study

Min-Kyung Lee
Jung Heo
Yong Sang Song
Research22 Aug 2025
International Journal of Obesity

Volume: 49, P: 2094-2101
Narrow bandgap silver mercury telluride alloy semiconductor nanocrystal for self-powered midwavelength-infrared photodiode

Infrared colloidal quantum dots are interesting due to their low-cost fabrication and wavelength tunability for optoelectronic applications. Here, air-stable low-noise mid-infrared photodiode devices are fabricated using hole-doped Ag-HgTe nanocrystals.

Haemin Song
So Young Eom
Kwang Seob Jeong
ResearchOpen Access24 Apr 2024
Communications Materials

Volume: 5, P: 1-9
National and regional trends in the prevalence of type 2 diabetes and associated risk factors among Korean adults, 2009–2021

Jiyeon Oh
Soeun Kim
Dong Keon Yon
ResearchOpen Access04 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
High-Performance Conducting Polymer Nanotube-based Liquid-Ion Gated Field-Effect Transistor Aptasensor for Dopamine Exocytosis

Seon Joo Park
Jiyeon Lee
Oh Seok Kwon
ResearchOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
National prevalence of smoking among adolescents at tobacco tax increase and COVID-19 pandemic in South Korea, 2005–2022

Seohyun Hong
Selin Woo
Dong Keon Yon
ResearchOpen Access03 Apr 2024
Scientific Reports

Volume: 14, P: 1-11
Peroxiredoxin 1 inhibits streptozotocin-induced Alzheimer’s disease-like pathology in hippocampal neuronal cells via the blocking of Ca²⁺/Calpain/Cdk5-mediated mitochondrial fragmentation

Junghyung Park
Jinyoung Won
Youngjeon Lee
ResearchOpen Access08 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Automated detection of intracranial aneurysms using skeleton-based 3D patches, semantic segmentation, and auxiliary classification for overcoming data imbalance in brain TOF-MRA

Sungwon Ham
Jiyeon Seo
Namkug Kim
ResearchOpen Access25 Jul 2023
Scientific Reports

Volume: 13, P: 1-9
Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea

Shin Young Park
Sunmi Han
Mi-sun Park
ResearchOpen Access28 Jan 2020
Scientific Reports

Volume: 10, P: 1-10

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