Nature Search

Determinants of genetic variation across eco-evolutionary scales in pinnipeds

Using comparative population genomics across pinnipeds, this study explores how demographic change and life-history traits are correlated to the effective size of a population and conservation status.

Claire R. Peart
Sergio Tusso
Jochen B. W. Wolf
Research08 Jun 2020
Nature Ecology & Evolution

Volume: 4, P: 1095-1104
Missense glucokinase mutation in maturity–onset diabetes of the young and mutation screening in late–onset diabetes

M. Stoffel
P. Patel
J.S. Wainscoat
Research01 Oct 1992
Nature Genetics

Volume: 2, P: 153-156
Low magnetic flux noise observed in laser-deposited in situ films of YB₂Cu₃O_y and implications for high- T_c SQUIDs

M. J. Ferrari
Mark Johnson
T. Venkatesan
Research26 Oct 1989
Nature

Volume: 341, P: 723-725
A mouse model for the human lysosomal disease aspartylglycosaminuria

Vesa Kaartinen
Ilkka Mononen
John Groffen
Research01 Dec 1996
Nature Medicine

Volume: 2, P: 1375-1378
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

Nanda A. Singh
Carole Charlier
Mark Leppert
Research01 Jan 1998
Nature Genetics

Volume: 18, P: 25-29
Iron absorption and loss, and efficacy of iron supplementation with and without prebiotics in children with virally suppressed HIV: three prospective studies in South Africa

Children living with HIV face a heightened risk of iron deficiency, yet optimal prevention and treatment strategies remain elusive. In these three prospective studies in South African children living with HIV, the authors show reduced dietary iron absorption but adequate absorption from iron supplements. Prebiotics may enhance efficacy and safety of oral iron supplementation in iron-deficient children living with HIV.

Jeannine Baumgartner
Renée Blaauw
Michael B. Zimmermann
ResearchOpen Access13 Nov 2025
Nature Communications

Volume: 16, P: 1-15
A novel therapeutic strategy for pancreatic neoplasia using a novel RNAi platform targeting PDX-1

Zhaohui Wang
Kelly Stehling
Marie-Claude Gingras
ResearchOpen Access22 Jun 2011
Nature Precedings

P: 1
MyomiR-133 regulates brown fat differentiation through Prdm16

Brown adipose tissue generates heat on exposure to cold temperatures. Stoffel and colleagues identify a cold-regulated pathway that increases levels of the transcriptional regulator Prdm16 to promote brown adipogenesis.

Mirko Trajkovski
Kashan Ahmed
Markus Stoffel
Research11 Nov 2012
Nature Cell Biology

Volume: 14, P: 1330-1335
Transcribing diabetes

John A. Todd
News & Views05 Dec 1996
Nature

Volume: 384, P: 407-408
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

Gerene M. Denning
Matthew P. Anderson
Michael J. Welsh
Research27 Aug 1992
Nature

Volume: 358, P: 761-764
Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Recent work found that overexpression of short hairpin RNAs in cells could lead to mortality in mice, this was attributed to interference with the cellular machinery that makes miRNAs. This raised the issue of whether RNA interference-mediated silencing would be therapeutically possible. This paper shows that small interfering RNAs can be systemically administered and effectively suppress gene expression without compromising the activity of various liver miRNAs.

Matthias John
Rainer Constien
David Bumcrot
Research26 Sept 2007
Nature

Volume: 449, P: 745-747
Troponin T Expression in Normal and Pressure-Loaded Fetal Sheep Heart

John J McAuliffe
Jeffrey Robbins
Research01 Jun 1991
Pediatric Research

Volume: 29, P: 580-585
Demographic histories and genetic diversity across pinnipeds are shaped by human exploitation, ecology and life-history

Historical hunting has caused documented declines in pinnipeds, but the extent to which hunting caused genetic bottlenecks among species was unknown. Here, the authors show evidence of severe bottlenecks in several pinniped species, particularly those that breed on land.

M. A. Stoffel
E. Humble
J. I. Hoffman
ResearchOpen Access16 Nov 2018
Nature Communications

Volume: 9, P: 1-12
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Base editors are effective and safe for cholesterol reduction in non-human primates.

Tanja Rothgangl
Melissa K. Dennis
Gerald Schwank
ResearchOpen Access19 May 2021
Nature Biotechnology

Volume: 39, P: 949-957
Interfering with disease: a progress report on siRNA-based therapeutics

RNA interference (RNAi) has rapidly advanced since its initial discovery to form the basis of a new class of therapeutics. De Fougerolles and colleagues discuss the challenges in the development of RNAi-based therapeutics, focusing on lead identification/optimization and effective delivery, and review the latest clinical results.

Antonin de Fougerolles
Hans-Peter Vornlocher
Judy Lieberman
Reviews01 Jun 2007
Nature Reviews Drug Discovery

Volume: 6, P: 443-453
Factors impacting bowel symptoms in a contemporary spinal cord injury cohort: results from the Neurogenic Bladder Research Group Registry

John T. Stoffel
Paholo Barboglio-Romo
Blayne Welk
Research03 Aug 2021
Spinal Cord

Volume: 59, P: 997-1002
First study of incontinent ileovesicostomy in children

Although a moderate body of evidence supports the efficacy of ileovesicostomy for neurogenic bladder in adults, its use in children has been largely undocumented. However, recent data show that this procedure should be considered for a selected paediatric population.

John T. Stoffel
News & Views22 Oct 2013
Nature Reviews Urology

Volume: 10, P: 621-622
Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes

Andrew B West
Alexander Zimprich
Thomas Gasser
Research14 Sept 2001
European Journal of Human Genetics

Volume: 9, P: 659-666
LNA blockers for improved amplification selectivity

Jaime Prout
Michael Tian
John F. Thompson
ResearchOpen Access24 Mar 2023
Scientific Reports

Volume: 13, P: 1-13
Frequency of patient-reported UTIs is associated with poor quality of life after spinal cord injury: a prospective observational study

Katherine M. Theisen
Rachel Mann
Sean P. Elliott
Research14 May 2020
Spinal Cord

Volume: 58, P: 1274-1281
Patient subjective assessment of urinary tract infection frequency and severity is associated with bladder management method in spinal cord injury

Joshua D. Roth
Joseph J. Pariser
Sean P. Elliott
Research14 Mar 2019
Spinal Cord

Volume: 57, P: 700-707
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

Jürgen Soutschek
Akin Akinc
Hans-Peter Vornlocher
Research11 Nov 2004
Nature

Volume: 432, P: 173-178
MicroRNAs 103 and 107 regulate insulin sensitivity

Mirko Trajkovski
Jean Hausser
Markus Stoffel
Research08 Jun 2011
Nature

Volume: 474, P: 649-653
Molecular similarity of Drosophila melanogaster alcohol dehydrogenase thermostable alleles from populations on different continents

John B Gibson
Darryl Reed
Chengshan Jiang
Research01 Aug 1990
Heredity

Volume: 65, P: 1-6
A Y-like social chromosome causes alternative colony organization in fire ants

Fire ants (Solenopsis invicta) are socially polymorphic, with some workers tolerating several queens in their colony and others tolerating just one; this study shows that a non-recombining supergene is responsible for this social polymorphism, and the operation of this genomic region is remarkably similar to that of sex chromosomes.

John Wang
Yannick Wurm
Laurent Keller
Research16 Jan 2013
Nature

Volume: 493, P: 664-668
Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence03 Oct 2019
Nature Biotechnology

Volume: 37, P: 1261-1263
Virus Resistant Papaya Plants Derived from Tissues Bombarded with the Coat Protein Gene of Papaya Ringspot Virus

Maureen M. M. Fitch
Richard M. Manshardt
John C. Sanford
Research01 Nov 1992
Bio/Technology

Volume: 10, P: 1466-1472
Production of Recombinant Bovine Enterokinase Catalytic Subunit in Escherichia coli Using the Novel Secretory Fusion Partner DsbA

Lisa A. Collins-Racie
James M. McColgan
Edward R. LaVallie
Research01 Sept 1995
Bio/Technology

Volume: 13, P: 982-987
Limited genetic differentiation among wild Oryctolagus cuniculus L. (rabbit) populations in arid eastern Australia

Susan J Fuller
Peter B Mather
John C Wilson
Research01 Aug 1996
Heredity

Volume: 77, P: 138-145
Malignant neoplasms associated with cancer of the ampulla of Vater

Elizabeth E Hatch
Rochelle E Curtis
Joseph F Fraumeni Jr
Correspondence01 Dec 1992
British Journal of Cancer

Volume: 66, P: 1204
New Genetic Methods for Mammalian Cells

John M. Sedivy
Reviews01 Oct 1988
Bio/Technology

Volume: 6, P: 1192-1196
Psychosocial aspects of health-related quality of life and the association with patient-reported bladder symptoms and satisfaction after spinal cord injury

Odinachi Moghalu
John T. Stoffel
Jeremy Myers
Research25 Jan 2021
Spinal Cord

Volume: 59, P: 987-996
Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Christos Mikropoulos
Christina G Hutten Selkirk
Rosalind A Eeles
ResearchOpen Access04 Jan 2018
British Journal of Cancer

Volume: 118, P: 266-276

Search

Determinants of genetic variation across eco-evolutionary scales in pinnipeds

Missense glucokinase mutation in maturity–onset diabetes of the young and mutation screening in late–onset diabetes

Low magnetic flux noise observed in laser-deposited in situ films of YB₂Cu₃O_y and implications for high- T_c SQUIDs

A mouse model for the human lysosomal disease aspartylglycosaminuria

A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

Iron absorption and loss, and efficacy of iron supplementation with and without prebiotics in children with virally suppressed HIV: three prospective studies in South Africa

A novel therapeutic strategy for pancreatic neoplasia using a novel RNAi platform targeting PDX-1

MyomiR-133 regulates brown fat differentiation through Prdm16

Transcribing diabetes

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Troponin T Expression in Normal and Pressure-Loaded Fetal Sheep Heart

Demographic histories and genetic diversity across pinnipeds are shaped by human exploitation, ecology and life-history

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Interfering with disease: a progress report on siRNA-based therapeutics

Factors impacting bowel symptoms in a contemporary spinal cord injury cohort: results from the Neurogenic Bladder Research Group Registry

First study of incontinent ileovesicostomy in children

Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes

LNA blockers for improved amplification selectivity

Frequency of patient-reported UTIs is associated with poor quality of life after spinal cord injury: a prospective observational study

Patient subjective assessment of urinary tract infection frequency and severity is associated with bladder management method in spinal cord injury

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

MicroRNAs 103 and 107 regulate insulin sensitivity

Molecular similarity of Drosophila melanogaster alcohol dehydrogenase thermostable alleles from populations on different continents

A Y-like social chromosome causes alternative colony organization in fire ants

Chinese scientists and US leadership in the life sciences

Virus Resistant Papaya Plants Derived from Tissues Bombarded with the Coat Protein Gene of Papaya Ringspot Virus

Production of Recombinant Bovine Enterokinase Catalytic Subunit in Escherichia coli Using the Novel Secretory Fusion Partner DsbA

Limited genetic differentiation among wild Oryctolagus cuniculus L. (rabbit) populations in arid eastern Australia

Malignant neoplasms associated with cancer of the ampulla of Vater

New Genetic Methods for Mammalian Cells

Psychosocial aspects of health-related quality of life and the association with patient-reported bladder symptoms and satisfaction after spinal cord injury

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

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