Loh et al. investigate the role of LRP5 mutations in adipose tissue biology. They demonstrate that LRP5 promotes lower-body fat distribution and enhances systemic and adipocyte insulin sensitivity, which suggests that pharmacological activation of LRP5 could prevent age-related fat redistribution and metabolic complications.
- Nellie Y. Loh
- Senthil K. Vasan
- Constantinos Christodoulides
