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Showing 1–13 of 13 results
Advanced filters: Author: Jonathan R. Brestoff Clear advanced filters

  • Intercellular mitochondria transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticism. In this Viewpoint, different experts in mitochondrial biology share their personal view on the topic.

    • Navdeep S. Chandel
    • Marni J. Falk
    • Rubén Quintana-Cabrera
    Reviews
    Nature Metabolism
    Volume: 7, P: 1716-1719

  • Administration of exogenous mitochondria from mice or humans, or stimulation of mitochondria transfer from haematopoietic cells through bone marrow transplant from wild-type mice, is shown to improve morbidity and mortality in a mouse model of the mitochondrial disease Leigh syndrome.

    • Ritsuko Nakai
    • Stella Varnum
    • Jonathan R. Brestoff
    Research
    Nature Metabolism
    Volume: 6, P: 1886-1896

  • A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes in adipose tissue thermogenesis is identified.

    • Xuejing Liu
    • Anyuan He
    • Irfan J. Lodhi
    ResearchOpen Access
    Nature
    Volume: 646, P: 1223-1231

  • Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering the circulation. Here, we briefly review the state of research into mitochondria transfer, and discuss a methodological framework for studying the process.

    • Snigdha Tiash
    • Jonathan Robert Brestoff
    • Clair Crewe
    Comments & Opinion
    Nature Cell Biology
    Volume: 25, P: 1551-1553

  • The mechanisms by which mitochondria are transferred between cells and how intercellular mitochondria transfer regulates physiological processes and disease pathogenesis are discussed.

    • Nicholas Borcherding
    • Jonathan R. Brestoff
    Reviews
    Nature
    Volume: 623, P: 283-291

  • Group 2 innate lymphoid cells are shown to have a critical role in energy homeostasis by producing methionine-enkephalin peptides in response to interleukin 33, thus promoting the beiging of white adipose tissue; increased numbers of beige (also known as brown-like or brite) fat cells in white adipose tissue leads to increased energy expenditure and decreased adiposity.

    • Jonathan R. Brestoff
    • Brian S. Kim
    • David Artis
    Research
    Nature
    Volume: 519, P: 242-246