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Showing 1–3 of 3 results
Advanced filters: Author: Jonathan R. Chekan Clear advanced filters
  • A two-enzyme complex works as a cyclodehydratase to form TOMM natural products, but the roles of each protein have been unclear. Structural and biochemical analysis deconvolutes the roles of each protein and identifies a new ATP-binding motif.

    • Kyle L Dunbar
    • Jonathan R Chekan
    • Douglas A Mitchell
    Research
    Nature Chemical Biology
    Volume: 10, P: 823-829
  • Aromatic side-chain crosslinking is emerging as a widespread and biosynthetically diverse feature in the RiPP natural products. This Review summarizes and unifies recent advancements, focusing on key enzymes that catalyze these modifications.

    • Sanath K. Kandy
    • Michael A. Pasquale
    • Jonathan R. Chekan
    Reviews
    Nature Chemical Biology
    Volume: 21, P: 168-181