The omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid alleviate inflammatory pain in patients. Ru-Rong Ji and his colleagues find that the resolvins RvE1 and RvD1, which are derived from omega-3 fatty acids, potently reduce pain in a number of animal models of inflammatory pain. These effects are mediated by both peripheral and central mechanisms and suggest that resolvins may represent a new class of analgesics for inflammatory pain (pages 518–520).
- Zhen-Zhong Xu
- Ling Zhang
- Ru-Rong Ji
