Nature Search

De novo and inherited dominant variants in U4 and U6 snRNA genes cause retinitis pigmentosa

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

Mathieu Quinodoz
Kim Rodenburg
Carlo Rivolta
ResearchOpen Access09 Jan 2026
Nature Genetics

Volume: 58, P: 169-179
Neutrophils preserve energy storage in sympathetically activated adipocytes

Neutrophil-derived IL-1β has a role in preserving lipid stores during metabolic stress.

Seunghwan Son
Cindy Xu
Alan R. Saltiel
Research10 Dec 2025
Nature

P: 1-9
Air Raid Precautions

J. D. BERNAL
J. H. FREMLIN
W. A. WOOSTER
Research01 May 1937
Nature

Volume: 139, P: 760-761
Vitamin E Affects Lung Biochemical and Morphologic Response to Hyperoxia in the Newborn Rabbit

David F Wender
Gunilla E Thulin
Joseph B Warshaw
Research01 Mar 1981
Pediatric Research

Volume: 15, P: 262-268
Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma

Jill M. Lahti
Marcus Valentine
Vincent J. Kidd
Research01 Jul 1994
Nature Genetics

Volume: 7, P: 370-375
Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

Joseph P. Steiner
Maureen A. Connolly
Solomon H. Snyder
Research01 Apr 1997
Nature Medicine

Volume: 3, P: 421-428
Effect of Hyperoxia on Antioxidants in Neonatal Rat Type II Cells in Vitro and in Vivo

Kathleen A Kennedy
Louis S Crouch
Joseph B Warshaw
Research01 Nov 1989
Pediatric Research

Volume: 26, P: 400-403
Response of the Testicular Capsule to Acetylcholine and Noradrenaline

JOSEPH R. DAVIS
GEORGE A. LANGFORD
Research26 Apr 1969
Nature

Volume: 222, P: 386-387
The Responses of Glutathione and Antioxidant Enzymes to Hyperoxia in Developing Lung

Joseph B Warshaw
Charlie W Wilson III
Russell A Prough
Research01 Aug 1985
Pediatric Research

Volume: 19, P: 819-823
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor

Joseph P. Brown
Daniel R. Twardzik
George J. Todaro
Research07 Feb 1985
Nature

Volume: 313, P: 491-492
Effect of Lead Exposure on the Activity of Some Hepatic Enzymes in the Rat

Gabriel Dinari
Michael I Cohen
Joseph A Kochen
Research01 May 1979
Pediatric Research

Volume: 13, P: 644-646
SNM1A is crucial for efficient repair of complex DNA breaks in human cells

Broken chromosomes are lethal to cells with breaks ends often containing complex DNA damage. Here, the authors reveal a key role for the SNM1A enzyme in cleaning up break ends. Key anticancer drugs, and therapeutic radiation produce complex DNA breaks, making SNM1A an appealing therapeutic target.

Lonnie P. Swift
B. Christoffer Lagerholm
Peter J. McHugh
ResearchOpen Access25 Jun 2024
Nature Communications

Volume: 15, P: 1-17
Late Cretaceous and paroxysmal Cretaceous/Tertiary extinctions

Charles B. Officer
Anthony Hallam
Joseph D. Devine
Reviews01 Mar 1987
Nature

Volume: 326, P: 143-149
Measuring the semantic priming effect across many languages

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Erin M. Buchanan
Kelly Cuccolo
Savannah C. Lewis
Research24 Sept 2025
Nature Human Behaviour

Volume: 10, P: 182-201
A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex

The authors describe an integrated atlas of the diverse cell types in the mouse primary motor cortex.

Zizhen Yao
Hanqing Liu
Eran A. Mukamel
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 103-110
Multiple Leukocyte Abnormalities in Chronic Granulomatous Disease: A Familial Study

William D Rutenberg
Mei C Yang
Joseph A Bellanrti
Research01 Mar 1977
Pediatric Research

Volume: 11, P: 158-163
Single-cell RNA sequencing reveals plasmid constrains bacterial population heterogeneity and identifies a non-conjugating subpopulation

Transcriptional heterogeneity in isogenic bacterial populations can play various roles in bacterial evolution, but its detection remains technically challenging. Here, Cyriaque et al. use microbial split-pool ligation transcriptomics to study the relationship between bacterial subpopulation formation and plasmid-host interactions at the single-cell level, providing insights into plasmid-bacteria dynamics.

Valentine Cyriaque
Rodrigo Ibarra-Chávez
Jonas Stenløkke Madsen
ResearchOpen Access12 Jul 2024
Nature Communications

Volume: 15, P: 1-10
Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: the HGB-205 trial

The final report of the phase 1/2 lentiviral gene therapy trial in severe β-hemoglobinopathies, HGB-205, shows a long-term safety profile and sustained reduction of transfusion requirements in patients with β-thalassemia and of sickle cell crises in patients with sickle cell disease.

Elisa Magrin
Michaela Semeraro
Marina Cavazzana
Research24 Jan 2022
Nature Medicine

Volume: 28, P: 81-88
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

Increased glycogen metabolism in adipocytes leads to expression of uncoupling protein 1, thereby linking glucose metabolism to thermogenesis.

Omer Keinan
Joseph M. Valentine
Alan R. Saltiel
Research27 Oct 2021
Nature

Volume: 599, P: 296-301
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Large-scale Mendelian randomization and colocalization analyses using gene expression and soluble protein data for 1,263 actionable druggable genes, which encode protein targets for approved drugs or drugs in clinical development, identify IFNAR2 and ACE2 as the most promising therapeutic targets for early management of COVID-19.

Liam Gaziano
Claudia Giambartolomei
Juan P. Casas
Research09 Apr 2021
Nature Medicine

Volume: 27, P: 668-676
A multimodal cell census and atlas of the mammalian primary motor cortex

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Edward M. Callaway
Hong-Wei Dong
Susan Sunkin
ResearchOpen Access06 Oct 2021
Nature

Volume: 598, P: 86-102
Structure and reactivity of a mononuclear non-haem iron(III)–peroxo complex

Jaeheung Cho
Sujin Jeon
Wonwoo Nam
Research26 Oct 2011
Nature

Volume: 478, P: 502-505
Heme is involved in microRNA processing

Michael Faller
Michio Matsunaga
Feng Guo
Research10 Dec 2006
Nature Structural & Molecular Biology

Volume: 14, P: 23-29
Genome sequence, comparative analysis and haplotype structure of the domestic dog

Kerstin Lindblad-Toh
Claire M Wade
Eric S. Lander
Research08 Dec 2005
Nature

Volume: 438, P: 803-819
Evolution of genes and genomes on the Drosophila phylogeny

An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

Andrew G. Clark
Michael B. Eisen
Iain MacCallum
Research08 Nov 2007
Nature

Volume: 450, P: 203-218
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

The genome of the grey short-tailed opossum Monodelphis domestica has been sequenced and analyzed, giving a first peek at a marsupial's genetic code. Of particular interest are the genetics of the immune system, which has been studied as a model for humans, and of the X chromosome for historical reasons.

Tarjei S. Mikkelsen
Matthew J. Wakefield
Kerstin Lindblad-Toh
Research10 May 2007
Nature

Volume: 447, P: 167-177
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Subcontinental heat wave triggers terrestrial and marine, multi-taxa responses

Katinka X. Ruthrof
David D. Breshears
Giles E. St. J. Hardy
ResearchOpen Access30 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
Serotonin Transporter and Seasonal Variation in Blood Serotonin in Families with Obsessive-Compulsive Disorder

Gregory L Hanna
Joseph A Himle
Edwin H Cook Jr
Research01 Feb 1998
Neuropsychopharmacology

Volume: 18, P: 102-111
Probing magnon–magnon coupling in exchange coupled Y\(_3\)Fe\(_5\)O\(_{12}\)/Permalloy bilayers with magneto-optical effects

Yuzan Xiong
Yi Li
Wei Zhang
ResearchOpen Access28 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Structure and specificity of the Type VI secretion system ClpV-TssC interaction in enteroaggregative Escherichia coli

Badreddine Douzi
Yannick R. Brunet
Christian Cambillau
ResearchOpen Access04 Oct 2016
Scientific Reports

Volume: 6, P: 1-13
OptiJ: Open-source optical projection tomography of large organ samples

Pedro P. Vallejo Ramirez
Joseph Zammit
Clemens F. Kaminski
ResearchOpen Access30 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Inhibition of HECT E3 ligases as potential therapy for COVID-19

Giuseppe Novelli
Jing Liu
Pier Paolo Pandolfi
ResearchOpen Access24 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-18
New and developing diagnostic technologies for urinary tract infections

Timely and accurate identification and determination of the antimicrobial susceptibility of uropathogens is central to the management of UTIs and antimicrobial stewardship. In this Review, Davenport and colleagues discuss emerging technologies including biosensors, microfluidics, and other integrated platforms that could improve UTI diagnosis and treatment choice.

Michael Davenport
Kathleen E. Mach
Joseph C. Liao
Reviews01 Mar 2017
Nature Reviews Urology

Volume: 14, P: 296-310
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

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