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Encounters between the replication and transcription machineries occur frequently in bacterial cells and are detrimental to fitness. Here, Grossman, Wang and colleagues review the two different types of replication–transcription conflict and describe the mechanisms that bacteria use to prevent and resolve these conflicts.

Single-crystal 2D metals are stabilized at the interface between epitaxial graphene and silicon carbide, with strong internal gradients in bonding character. The confined 2D metals demonstrate compelling superconducting properties.

While biological fluoride ion channels display excellent F⁻ conductivity and selectivity, designing synthetic analogues remains highly challenging. Here the authors show that zirconium-based metal–organic frameworks with F⁻ binding sites and sub-1-nanometer channels exhibit ultrahigh F⁻ conductivity and selectivity.

The mechanisms regulating regeneration of the earthworm are unclear. Here, the authors use genomic and transcriptomic analysis of the earthworm Eisenia andrei together with Hi-C analysis to identify genes involved and show activation of LINE2 transposable elements on regeneration.

Realizing efficient n-doping in organic thermoelectrics remains a challenge due to dopant-semiconductor immiscibility, poor dopant stability and low doping efficiency. Here, the authors use computer-assisted screening to develop n-dopants for thermoelectric polymers that show record power factors.

AMP-activated protein kinase (AMPK) has a central role in sensing cellular metabolic levels. Crystal structures of the AMPK core in the presence of AMP or ATP suggest that the third nucleotide-binding site in the γ subunit is important for allosteric regulation of kinase activity.

Fine-tuning the RoseTTAFold structure prediction network on protein structure denoising tasks yields a generative model for protein design that achieves outstanding performance on a wide range of protein structure and function design challenges.

Metal potassium anodes show great potential in high energy density batteries. However, their practical application is hindered by the unstable nature of the highly active metal surface. Here, authors propose a “metal skin” approach that stabilizes the surface of the metal, resulting in improved cycle life of potassium metal anode-based batteries.

Nucleotides pppGpp and ppGpp regulate bacterial responses to nutritional and other stresses, while the potential roles of the related pGpp are unclear. Here, Yang et al. systematically identify proteins interacting with these nucleotides in Bacillus, and show that pGpp has roles distinct from those of (p)ppGpp.

Aqueous sodium-ion batteries could be a potential solution for large-scale energy storage, but the conventional negative electrodes are not efficient. Here, the authors report a titanium-substituted tunnel-type Na_0.44MnO₂material as a promising negative electrode for aqueous sodium-ion batteries.

Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers and have genetic overlap. Here, the authors use a multi-trait genetic and phenotypic analysis to reveal susceptibility loci for BCC and SCC, and report an optimised polygenic risk score for risk stratification.

Orbital multiferroicity reported in pentalayer rhombohedral graphene features ferro-orbital-magnetism and ferro-valleytricity, both of which can be controlled by an electric field.

Thorp et al. use symptom-level genetic modelling to identify 61 and 73 genomic loci associated with depression and anxiety, respectively, and reveal that they possess highly similar genetic architectures.

Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs). Here authors unveil a mechanism by which PI(4,5)P₂/PI(3,4)P₂ allosterically enhances ORP1-mediated cholesterol exit from LELs.

The combination of piezoresponse force microscopy and optical measurements reveals the influence of strain in the formation of one-dimensional moiré patterns and the resulting behaviour of interlayer excitons in van der Waals heterostructures.

Analyses of genetic variation and population structure based on over 3,000 cultivated rice (Oryza sativa) genomes reveal subpopulations that correlate with geographic location and patterns of introgression consistent with multiple rice domestication events.

The mode of action of Ap4A on IMPDH to regulate GTP production in Bacillus subtilis is identified.

Low-cost targeted approach to construct haplotype-resolved assemblies is needed to facilitate population genetic studies. Here, the authors demonstrate assembling high-quality MHC haplotypes with CRISPR-based enrichment and long-read sequencings.

Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia, and there is currently no treatment. Here, the authors report and utilize small molecule positive regulators of GRN expression to boost progranulin levels from the remaining functional GRN allele, thus restoring progranulin levels back to normal within the brain.

Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold selectivity for GluN2C/2D compared to GluN2A.

Runx family proteins direct lineage-fate decisions in multiple cell types. Here, Rothenberg and colleagues show how limited Runx protein abundance dictates T cell lineage developmental kinetics through competition for binding by its protein interaction partners.

Multitrait genome-wide association analyses identify hundreds of risk loci for primary open-angle glaucoma. Integration with other data types highlights potential new drug targets, including proteins likely to act via the optic nerve.

Pentalayer graphene in the rhombohedral stacking order exhibits rich phases including a correlated insulator, isospin-polarized metals and Chern insulators. These findings demonstrate electron-correlated and topological states in crystalline 2D materials without the need for a moiré superlattice.

Primary dysmenorrhoea, the most common gynaecologic complaint, remains genetically and pathophysiologically elusive. Here, Li and colleagues identify common variants inZMIZ1 and near NGFconferring risk for primary dysmenorrhoea using genome-wide association study in a Chinese population.

Li Yu, Ya-Ping Zhang, Chung-I Wu and colleagues report the de novo genome of the black snub-nosed monkey Rhinopithecus bieti and the genomic sequences of four other Rhinopithecus species, including three high-altitude and two lowland species. The species- and population-level genomic analyses as well as the transcriptomic analysis and functional assays find adaptive signatures associated with adaptation to high altitude.

There are currently no validated methods for the diagnosis of prion disease at the preclinical stage. Here the authors show that serial protein misfolding cyclic amplification and real-time quaking-induced conversion can be used to detect prions in the skin of prion-inoculated hamsters and humanized transgenic mice at early preclinical stages.

Light-responsive smart materials hold promise for a solution to water desalination. Here the authors report an adsorbent based on a metal–organic framework that quickly adsorbs multiple ions from water in the dark, followed by release of these salts on exposure to sunlight.

Here, using an interfacial growth strategy, UiO-66 MOF nanocrystals are asymmetrically embedded into conical pores in a polymer membrane. These pores have a mono/divalent cation selectivity of 10³, which can be tuned by pH, and act as ionic rectifiers.

H3K27me3 binding to the EED pocket of the Polycomb repressive complex 2 (PRC2) is required to activate PRC2. An allosteric small-molecule inhibitor of PRC2 was identified that binds to the EED pocket and blocks PRC2 methyltransferase activity in cells.

Poor electrochemical reversibility of the conversion-type cathode materials remains an important challenge for their practical applications. Here, the authors report a highly reversible fluoride cathode material with low hysteresis through concerted doping of cobalt and oxygen into iron fluoride.

Hyperinsulinemia can precede the development of insulin resistance. Here the authors identify a PKD2 mutation that leads to hyperinsulinemia and insulin resistance in Rhesus monkey and show that PKD2 deficiency promotes beta cell insulin secretion by activating L-type Ca2+ channels.

The formation of electrochemically inactive, or “dead”, lithium limits the reversibility of lithium metal batteries. Here the authors elucidate the (electro)chemical roles of ethylene gas produced from electrolyte decomposition on the formation of inactive lithium.

The fabrication of synthetic nanochannels for ion separation is challenging. Here, the authors synthesize angstrom-scale ion channels featuring one-dimensional to three-dimensional pore configurations by growing metal‒organic frameworks into nanochannels; the structure of the pore influences the ion transport performance.