Optically pure phosphonates are crucial in pharmaceuticals, yet the development of chiral H-phosphonates has been stagnant for decades. Here, the authors report an H-phosphonate derived from camphor-derived 2,3-diols (CAMDOL), that enables efficient stereoselective Pudovik reactions and yields diverse bioactive molecules, with significant implications for asymmetric synthesis.
- Ning Li
- Qian Wu
- Junhua Xiao
