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Quantitative methods to assess the quality of hPSC-derived organoids have not been developed. Here they present a prediction algorithm to assess the transcriptomic similarity between hPSC-derived organoids and the corresponding human target organs and perform validation on lung bud organoids, antral gastric organoids, and cardiomyocytes.

The ability to control the arrangement of plasmonic nanoparticles offers a promising approach to modulating optical properties. Here, the authors report on magnetically controllable assemblies of plasmonic nanoparticles in dispersion that exhibit dynamic birefringence and chirality.

Interactions between alveolar epithelial cells and macrophages shape lung development and function. Here Kang et al. develop alveolar assembloids by co-culturing alveolar organoids with macrophages providing a platform to model lung diseases.

Ferrimagnetic multilayers and alloys are shown to have an interesting thickness dependence of spin coherence length and spin torque efficiency. These results pave the way toward energy-efficient spintronics.

A portable device integrating reverse transcription, fast thermocycling and in situ fluorescence detection accurately detects SARS-CoV-2 RNA in patient samples in 17 min.

Doil Choi and colleagues report the genome sequence of the hot pepper, Capsicum annuum, as well as the resequencing of two cultivated peppers and a wild species, Capsicum chinense. Comparative genomic analysis across Solanaceae provides insights into genome expansion, pungency, ripening and disease resistance in hot peppers.

Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.

Longitudinal spin pumping is experimentally demonstrated using the magnetic phase transition of iron–rhodium, and the observed inverse spin Hall signal indicates that longitudinal spin pumping is driven by quantum fluctuations.

3D photonic nanostructures can manipulate the amplitude, phase, and polarization of light, but their bottom-up fabrication is hindered by limited structural control. Here, the authors present chiral 3D structures through multi-dimensional transfer printing of multilayer quantum dot patterns.

Analysis of genomic and transcriptomic data from 462 patient-derived tumor cell (PDC) samples across 14 cancer types, along with pharmacological responses to 60 agents, indicates that PDC-derived drug sensitivities might be predictive of clinical response to targeted therapies.

Analysis of 2,096 single-cell clones from three tissues of 31 healthy donors characterizes mitochondrial DNA mosaicism and highlights the following two origins of mtDNA variants: heteroplasmy in the fertilized egg and postzygotic mutations.

It is known that torques can be exerted on spins in a ferromagnet (FM) layer when an in-plane electric current is injected into a heavy metal (HM) layer in contact with the FM layer. Here, the authors demonstrate that torques can be generated without the current injection by shining instead circularly polarized light on the HM.

Tobacco smoking is an important risk factor for lung cancer. Here the authors report that tobacco carcinogens promote metabolic syndrome and metabolic reprogramming of macrophages, associated with lung cancer progression in preclinical models.

Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the activation of STAT3.

High-concentration lithium polysulfides in lean electrolyte lithium–sulfur batteries hinder stable cycling. Here, authors introduce a reversible calcium additive that regulates polysulfides chemistry and catalyzes sulfur redox reactions, improving energy density with stable cycling.

Practical electrochemical N₂ reduction reaction is challenged by competing side reactions. Here a combination of DFT and mikrokinetic modelling reveals the potential-dependent competition between electrochemical ammonia production and hydrogen evolution on a single-site iron catalyst embedded in N-doped graphene.

It is challenging to realize doping and surface passivation simultaneously in colloidal quantum dot inks. Here Choi et al. employ a cascade surface modification approach to solve the problem and obtain record high efficiency of 13.3% for bulk homojunction solar cells based on these inks.

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Improved design of three-dimensionally nanostructured catalysts for oxygen evolution reaction (OER) can play a key role in maximizing the catalytic performance. Here, the authors show that woodpile-structured iridium consisting of 3D-printed, highly-ordered nanowire building blocks significantly improve OER mass activity.

A new method ‘hypotaxy’ enables wafer-scale, single-crystal transition metal dichalcogenides growth directly on crystalline, lattice-mismatched and amorphous substrates.

Quorum sensing signaling molecules are known to be critical determinants in bacterial pathogenesis. Here the authors show the quorum sensing molecule cFP from Vibrio vulnificus inhibits the RIG-I mediated antiviral interferon response and enhances susceptibility to viral infection.

As perovskite-based solar cells are reaching high efficiency, issues of stability and end-of-life become predominant. Here, Kim et al. selectively dissolve the perovskite layer and reuse the electron transport layer to fabricate devices with efficiency and stability comparable to those of the original solar cells.

Glioblastoma is one of the most intractable tumors and presents a hypoxic and immunologically cold microenvironment. Lee and colleagues demonstrate that normalizing oxygen tension unleashes γδ T cell anti-glioblastoma function.

Protein nanocages are multimeric molecular structures that can be engineered to mimic conformations of microorganisms. Here the authors display antigen and adjuvant on ferritin nanocage and use as a mucosal vaccine showing induction of protective immunity in a murine model of Streptococcus pneumoniae infection.

Electrotactile systems can have inconsistent tactile results due to variations in pressure between the device and finger. Here, the authors report a transparent electrotactile device with pressure-sensitive transistors, enabling consistent electrotactility while interference stimulation maximizes the performance.

The genetic link between placenta function and congenital heart defects has been established, though the cellular mechanisms underlying this connection is less clear. Here they show that PIBF1 regulates syncytiotrophoblast fusion and that loss of PIBF1 also negatively impacts heart development, providing a potential link between the development of these two organs.

Pretreating rats with amine-modified single-walled carbon nanotubes can decrease brain injury and enhance recovery of behavioural functions after a stroke.

NF-κB activation contributes to colitis-associated colorectal cancer (CAC). Here the authors show that NF-κB subunit, p65 stabilizes ITF2, which then suppresses NF-κB downstream genes and inhibits CAC progression.

The limited operational stability of multi-resonance thermally activated delayed fluorescence emitters often constrains their practical application. Here, the authors report a direct correlation between device lifetime and Faradaic yield for oxidative degradation of emitter molecules.

The role of 3D genome organization is not well understood in the transcriptional regulation of dendritic cells. Here the authors show that activation of dendritic cells in vitro induces dynamic reprogramming of the chromatin looping and enhancer activity linked to changes in gene expression and implicates a role for the chromatin architecture protein CTCF in the inflammatory response of dendritic cells.