Nature Search

Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity

Chaoyi Xia
Xue Sun
Qiang Zhang
ResearchOpen Access14 Feb 2026
Cell Death & Disease

P: 1-11
New Late Pleistocene age for the Homo sapiens skeleton from Liujiang southern China

Here the authors provide new radiocarbon, U-series, and OSL dates for Homo sapiens fossils from Tongtianyan cave, southern China, placing them at 33-23 thousand years ago and indicating widespread presence of Homo sapiens across eastern Asia in the Late Pleistocene.

Junyi Ge
Song Xing
Qingfeng Shao
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-13
Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression

The functions of microvesicles (MVs) in gastric cancer are less studied compared to other types of extracellular vesicles. Here, the authors report that in Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC), Olfactomedin 4 protein is enriched in secreted MVs to promote EBVaGC progression by inhibiting the Hippo signaling in tumor cells.

Fuping Wen
Yi Han
Shi Jiao
ResearchOpen Access04 Dec 2024
Nature Communications

Volume: 15, P: 1-17
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression

Multi-omic analysis of 100 clear cell renal cell carcinomas identifies four transcriptomic subgroups (IM1–IM4). IM4 is a high-risk subtype characterized by specific metabolic changes and a loss of lipid droplets.

Junyi Hu
Shao-Gang Wang
Ke Chen
ResearchOpen Access15 Feb 2024
Nature Genetics

Volume: 56, P: 442-457
Broken symmetries associated with a Kagome chiral charge order

The symmetry and mechanism underlying unconventional charge orders in Kagome materials are under debate. Here, the authors uncover a longitudinal and helicity-dependent photocurrent in KV₃Sb₅ that indicates broken symmetries and intrinsic chirality.

Zi-Jia Cheng
Md Shafayat Hossain
M. Zahid Hasan
ResearchOpen Access22 Apr 2025
Nature Communications

Volume: 16, P: 1-8
Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment

Risk prediction for prognosis in colorectal cancer is an important tool. Here, the authors utilise GWAS from 5 cohorts of colorectal cancer patients, and show a healthy lifestyle is associated with a 7.6% improvement in overall survival among patients with high pathologic and genetic risk.

Junyi Xin
Dongying Gu
Meilin Wang
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-11
Mapping the neural and molecular basis underlying fatigue in Parkinson’s disease

Futing Yang
Junyi Shen
Jiaojian Wang
ResearchOpen Access29 Nov 2025
npj Parkinson's Disease

Volume: 12, P: 1-11
Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Platinum-based chemotherapeutics can be locally released in tumours by leveraging the radiation-induced reduction of platinum prodrugs.

Qunfeng Fu
Shuren Zhang
Zhibo Liu
Research18 Jul 2024
Nature Biomedical Engineering

Volume: 8, P: 1425-1435
Short-term effects of ambient air pollution and childhood lower respiratory diseases

Liyang Zhu
Xuhua Ge
Meilin Wang
ResearchOpen Access30 Jun 2017
Scientific Reports

Volume: 7, P: 1-7
Enhanced low-temperature proton conductivity in hydrogen-intercalated brownmillerite oxide

Solid oxide ionic conductors typically require elevated temperature to activate ionic transport. Here the authors report unusually high proton conductivity close to room temperature in a hydrogenated oxide, HSrCoO_2.5, which they attribute to the intrinsically ordered oxygen vacancy channels and high proton concentration.

Nianpeng Lu
Zhuo Zhang
Pu Yu
Research08 Dec 2022
Nature Energy

Volume: 7, P: 1208-1216
The Born in Guangzhou Cohort Study enables generational genetic discoveries

Analysis of data from the Born in Guangzhou Cohort Study comprising mainly of trios and mother–infant pairs reveals novel East Asian-specific genetic associations with maternal bile acid, gestational weight gain and infant cord blood traits.

Shujia Huang
Siyang Liu
Xiu Qiu
Research31 Jan 2024
Nature

Volume: 626, P: 565-573
USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1

Junyi Duan
Daoyuan Huang
Genze Shao
ResearchOpen Access06 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-15
Linc00423 as a tumor suppressor in retroperitoneal liposarcoma via activing MAPK signaling pathway through destabilizing of NFATC3

Yong Zhang
Hanxing Tong
Yuhong Zhou
ResearchOpen Access03 Jun 2019
Cell Death & Disease

Volume: 10, P: 1-13
The deubiquitinating enzyme USP4 regulates BRCA1 stability and function

Xueyuan Guo
Yanfang Ma
Genze Shao
ResearchOpen Access11 May 2024
npj Breast Cancer

Volume: 10, P: 1-14
The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis

The BRCC36 isopeptidase complex (BRISC) is identified as the deubiquitinating enzyme for Lys63-linked ubiquitination of Aurora B, and hyperactivated Aurora B in the absence of BRISC leads to erroneous chromosome–microtubule attachment during mitosis.

Qin Li
Yanfang Ma
Li Li
ResearchOpen Access06 Dec 2022
Communications Biology

Volume: 5, P: 1-16

Search

Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity

New Late Pleistocene age for the Homo sapiens skeleton from Liujiang southern China

Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression

Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression

Broken symmetries associated with a Kagome chiral charge order

Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment

Mapping the neural and molecular basis underlying fatigue in Parkinson’s disease

Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Short-term effects of ambient air pollution and childhood lower respiratory diseases

Enhanced low-temperature proton conductivity in hydrogen-intercalated brownmillerite oxide

The Born in Guangzhou Cohort Study enables generational genetic discoveries

USP11-mediated LSH deubiquitination inhibits ferroptosis in colorectal cancer through epigenetic activation of CYP24A1

Linc00423 as a tumor suppressor in retroperitoneal liposarcoma via activing MAPK signaling pathway through destabilizing of NFATC3

The deubiquitinating enzyme USP4 regulates BRCA1 stability and function

The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis

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