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Showing 1–16 of 16 results
Advanced filters: Author: Justin G. Fedor Clear advanced filters

  • The heteromeric insect TRPV channel, Nanchung-Inactive, is a previously structurally uncharacterized insecticide target. Here, Fedor et al. provide insights into how an insecticide and a natural agonist modulate channel behavior, paving the way for future insecticide development.

    • Justin G. Fedor
    • Ramani Kandasamy
    • Seok-Yong Lee
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

    • Alec Eickbusch
    • Matt McEwen
    • Alexis Morvan
    ResearchOpen Access
    Nature Physics
    Volume: 21, P: 1994-2001

  • URAT1 is the target for gout drugs that block urate reuptake in the kidneys, however current treatments have limitations. Here, authors show how urate-lowering drugs inhibit URAT1, facilitating antigout drug development.

    • Yang Suo
    • Justin G. Fedor
    • Seok-Yong Lee
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

    • Dmitry A. Abanin
    • Rajeev Acharya
    • Nicholas Zobrist
    ResearchOpen Access
    Nature
    Volume: 646, P: 825-830

  • The respiratory complex I (NADH:ubiquinone oxidoreductase) is a large redox-driven proton pump that initiates respiration in mitochondria. Here, the authors present the 3.0 Å cryo-EM structure of complex I from mouse heart mitochondria with the ubiquinone-analogue inhibitor piericidin A bound in the active site and with kinetic measurements and MD simulations they further show that this inhibitor acts competitively against the native ubiquinone-10 substrate.

    • Hannah R. Bridges
    • Justin G. Fedor
    • Judy Hirst
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • In this study, Wrigth et al. use structural, medicinal chemistry, and behavioral approaches to examine how equilibrative nucleoside transporter subtype 1 (ENT1) exerts its functions; and their findings reveal ENT1 as a potential target for analgesia.

    • Nicholas J. Wright
    • Yutaka Matsuoka
    • Seok-Yong Lee
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • We present the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference.

    • Arang Rhie
    • Sergey Nurk
    • Adam M. Phillippy
    Research
    Nature
    Volume: 621, P: 344-354

  • A study establishes a scalable approach to engineer and characterize a many-body-localized discrete time crystal phase on a superconducting quantum processor.

    • Xiao Mi
    • Matteo Ippoliti
    • Pedram Roushan
    ResearchOpen Access
    Nature
    Volume: 601, P: 531-536

  • Cryo-EM often yields multiple protein conformations within a single dataset. Using the thermal titration methods and cryo-EM, Do Hoon Kwon et al. elucidate the conformational trajectory of the TRPV1 with resiniferatoxin (RTx) bound.

    • Do Hoon Kwon
    • Feng Zhang
    • Seok-Yong Lee
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Structural, functional and computational studies uncover the molecular details of antiviral drug recognition and membrane translocation by a concentrative nucleoside transporter.

    • Nicholas J. Wright
    • Feng Zhang
    • Seok-Yong Lee
    Research
    Nature Chemical Biology
    Volume: 20, P: 1144-1153

  • Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

    • Rajeev Acharya
    • Dmitry A. Abanin
    • Nicholas Zobrist
    ResearchOpen Access
    Nature
    Volume: 638, P: 920-926

  • Organic cation transporters (OCTs) are responsible for the hepatic uptake and renal clearance of well over 250 US Food and Drug Administration-approved drugs. Suo et al. solved cryo-electron microscopy structures of OCT variants in complex with xenobiotics, providing insights into drug recognition by OCTs.

    • Yang Suo
    • Nicholas J. Wright
    • Seok-Yong Lee
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 1001-1011

  • Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

    • Kevin C. Miao
    • Matt McEwen
    • Yu Chen
    ResearchOpen Access
    Nature Physics
    Volume: 19, P: 1780-1786