Nature Search

A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function

Here they combine in vivo imaging with proteomics to characterize a protein complex comprised of Ccdc78 and Ccdc33 that acts at the extreme distal tip of 9 + 2 motile cilia to control tip architecture, cilia length, and cilia beating.

Juyeon Hong
Chanjae Lee
John B. Wallingford
ResearchOpen Access21 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Near-infrared long lifetime upconversion nanoparticles for ultrasensitive microRNA detection via time-gated luminescence resonance energy transfer

Kim, Park, and colleagues present near-infrared long-lifetime upconversion nanoparticles combined with time-gated detection. These nanoparticles allow for improved performance of luminescence-based biosensing for sensitive and accurate microRNA analysis in cancer diagnostics.

Suyeon Kim
Yeonkyung Park
Joonseok Lee
ResearchOpen Access14 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining

Acquiring subcellular-level three-dimensional (3D) tissue structures efficiently without damaging the tissue remains challenging in histopathology. Here, the authors integrate holotomography with deep learning to generate 3D virtual H&E staining images from label-free thick cancer tissues, and apply this approach to colon and gastric cancer samples.

Juyeon Park
Su-Jin Shin
YongKeun Park
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-16
Structural basis for the recognition and ubiquitylation of type-2 N-degron substrate by PRT1 plant N-recognin

PRT1 is an E3 ligase that recognizes type-2 hydrophobic aromatic Arg/N-degrons. Here, the authors reveal the structure of the ZZ domain of Arabidopsis PRT1 bound to bulky hydrophobic type-2 N-degrons, showing a unique binding site formed by a substantial conformational change of two loops and uncovering an intramolecular tandem RING dimer essential for its ubiquitylation activity.

Woo Seok Yang
Seu Ha Kim
Hyun Kyu Song
ResearchOpen Access21 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Author Correction: Intracellular spatial transcriptomic analysis toolkit (InSTAnT)

Anurendra Kumar
Alex W. Schrader
Saurabh Sinha
Amendments and CorrectionsOpen Access25 Oct 2024
Nature Communications

Volume: 15, P: 1
Quasi-spatial single-cell transcriptome based on physical tissue properties defines early aging associated niche in liver

Tissue aging is associated with pro-fibrotic changes and stiffening of the extracellular matrix. Here the authors present FiNi-seq, a method that enriches fibrotic tissue based on its physical properties and thus captures aging-associated cell types. The study characterizes early fibrotic changes in liver tissue.

Kwon Yong Tak
Juyeon Kim
Jong-Eun Park
Research05 May 2025
Nature Aging

Volume: 5, P: 929-949
A vacuum-deposited polymer dielectric for wafer-scale stretchable electronics

A thin and stretchable polymer layer can be fabricated over large areas with high uniformity using a vacuum-deposition method and used as the gate dielectric in stretchy carbon-nanotube-based transistors and circuits that can function at 40% strain.

Ja Hoon Koo
Juyeon Kang
Donghee Son
Research02 Feb 2023
Nature Electronics

Volume: 6, P: 137-145
Crbn modulates calcium influx by regulating Orai1 during efferocytosis

Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.

Hyunji Moon
Chanhyuk Min
Daeho Park
ResearchOpen Access30 Oct 2020
Nature Communications

Volume: 11, P: 1-13
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel

Here the authors present the cryo-EM structures of heteromeric TRPC1/TRPC4 channel and provide structure–function insights into its heteromer-specific properties.

Jongdae Won
Jinhyeong Kim
Hyung Ho Lee
Research30 Oct 2024
Nature Structural & Molecular Biology

Volume: 32, P: 326-338
Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus

Rapid detection of antiviral resistant strains is important for effective clinical treatment. Here the authors develop an antibody which specifically binds to multidrug-resistant influenza virus and demonstrated detection in a number of different systems using the antibody.

Kyeonghye Guk
Hyeran Kim
Juyeon Jung
ResearchOpen Access09 Jul 2020
Nature Communications

Volume: 11, P: 1-11
Catalyst-free synthesis of sub-5 nm silicon nanowire arrays with massive lattice contraction and wide bandgap

The preparation of quantum silicon nanowires, materials with potential application in high-performance nanodevices, is challenging. Here, the authors synthesize vertically aligned sub-5 nm silicon nanowires via a vapor phase silicon etching process; the resulting material features unusual lattice reduction and significant phonon and electronic confinement effects.

Sen Gao
Sanghyun Hong
Yung Joon Jung
ResearchOpen Access20 Jun 2022
Nature Communications

Volume: 13, P: 1-9
Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

The type III secretion system effectors NleB and SseK are glycosyltransferases (GT) that specifically glycosylate arginine residues. Here the authors provide insights into their mechanism by combining X-ray crystallography, NMR, enzyme kinetics measurements, molecular dynamics simulations and in vivo experiments and show that SseK/NleB enzymes are retaining GTs.

Jun Bae Park
Young Hun Kim
Hyun-Soo Cho
ResearchOpen Access16 Oct 2018
Nature Communications

Volume: 9, P: 1-15
ANCA: artificial nucleic acid circuit with argonaute protein for one-step isothermal detection of antibiotic-resistant bacteria

Antibiotic-resistant bacteria pose a growing threat to global health. Here, the authors present an artificial nucleic acid circuit with argonaute protein (ANCA) for one-step, amplification-free, and isothermal detection of carbapenemase-producing Klebsiella pneumoniae.

Hyowon Jang
Jayeon Song
Taejoon Kang
ResearchOpen Access05 Dec 2023
Nature Communications

Volume: 14, P: 1-13
Intracellular spatial transcriptomic analysis toolkit (InSTAnT)

Here, the authors introduce the Intracellular Spatial Transcriptomic Analysis Toolkit (InSTAnT), which allows researchers to study the information encoded in the physical proximity of individual transcripts by detecting persistent subcellular patterns.

Anurendra Kumar
Alex W. Schrader
Saurabh Sinha
ResearchOpen Access06 Sept 2024
Nature Communications

Volume: 15, P: 1-19
Molecular architecture of the Gα_i-bound TRPC5 ion channel

Ion channels could be directly regulated by the alpha subunit of heterotrimeric G-proteins. Here, authors present the cryo-EM structure of an ion channel-Gα complex, TRPC5-Gα_i3, and present functional insights into their direct interaction.

Jongdae Won
Jinsung Kim
Hyung Ho Lee
ResearchOpen Access03 May 2023
Nature Communications

Volume: 14, P: 1-16
Artificial intelligence-enabled quantitative phase imaging methods for life sciences

This Perspective introduces advances in quantitative phase imaging and artificial intelligence-based image analysis and further describes how the two technologies intersect and synergize to enable biomedical research.

Juyeon Park
Bijie Bai
YongKeun Park
Reviews23 Oct 2023
Nature Methods

Volume: 20, P: 1645-1660
Dissecting phenotypic responses of the druggable targetome in cancers

Euna Jeong
Choa Park
Sukjoon Yoon
ResearchOpen Access29 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
Peptidoglycan binding protein (PGBP)-modified magnetic nanobeads for efficient magnetic capturing of Staphylococcus aureus associated with sepsis in blood

Jaewoo Lim
Jongmin Choi
Eun-Kyung Lim
ResearchOpen Access15 Jan 2019
Scientific Reports

Volume: 9, P: 1-7
Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival

In this study, the authors report that target-derived NGF signaling induces the expression of Coronin-1, which consequently gets recruited to the NGF-TrkA–carrying signaling endosome, where it regulates endosomal fusion with lysosomes, trafficking and recycling. In addition, Coronin-1 appears to be necessary for NGF-dependent signaling events such as CREB phosphorylation, Ca²⁺ release and activation of calcineurin.

Dong Suo
Juyeon Park
Christopher D Deppmann
Research24 Nov 2013
Nature Neuroscience

Volume: 17, P: 36-45
Machine-learning-based diagnosis of thyroid fine-needle aspiration biopsy synergistically by Papanicolaou staining and refractive index distribution

Young Ki Lee
Dongmin Ryu
Eun Kyung Lee
ResearchOpen Access17 Jun 2023
Scientific Reports

Volume: 13, P: 1-9
A scaffold for signaling of Tim-4-mediated efferocytosis is formed by fibronectin

Juyeon Lee
Boyeon Park
Daeho Park
Research19 Nov 2018
Cell Death & Differentiation

Volume: 26, P: 1646-1655
Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery

Kyunghee Noh
Soyeon Yi
Juyeon Jung
ResearchOpen Access10 Jul 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-15
Blockade of the vaspin–AP-1 axis inhibits arthritis development

Jimin Jeon
Chanmi Cho
Siyoung Yang
ResearchOpen Access03 Mar 2025
Experimental & Molecular Medicine

Volume: 57, P: 628-636
Modulatory effects of cinnamomi cortex and its components epicatechin and linalool on skin circadian rhythms

Ji-Young Kim
Juyeon Lee
Kyung-Ha Lee
ResearchOpen Access06 Feb 2025
Scientific Reports

Volume: 15, P: 1-13
Nationwide association between ambient ozone and sudden cardiac arrests in South Korea

Cinoo Kang
Yejin Kim
Whanhee Lee
ResearchOpen Access06 Jun 2025
Scientific Reports

Volume: 15, P: 1-11
Development of novel Meju starter culture using plant extracts with reduced Bacillus cereus counts and enhanced functional properties

Shruti Shukla
Juyeon Park
Myunghee Kim
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
Prognostic value of soluble PD-L1 and exosomal PD-L1 in advanced gastric cancer patients receiving systemic chemotherapy

Kabsoo Shin
Joori Kim
In-Ho Kim
ResearchOpen Access28 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Tim-4 functions as a scavenger receptor for phagocytosis of exogenous particles

Chanhyuk Min
Jeongjun Park
Daeho Park
ResearchOpen Access23 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-10
Rapid and simple detection of Tamiflu-resistant influenza virus: Development of oseltamivir derivative-based lateral flow biosensor for point-of-care (POC) diagnostics

Seul Gee Hwang
Kab Ha
Eun-Kyung Lim
ResearchOpen Access29 Aug 2018
Scientific Reports

Volume: 8, P: 1-11
Author Correction: SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion

Sunho An
Tam Thuy Lu Vo
Ji Hae Seo
Amendments and CorrectionsOpen Access29 Jul 2025
Experimental & Molecular Medicine

Volume: 57, P: 1618-1619
Loss of Mob1a/b impairs the differentiation of mouse embryonic stem cells into the three germ layer lineages

June Sung Bae
Sun Mi Kim
Ho Lee
ResearchOpen Access14 Nov 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-12
Deep learning model to predict Epstein–Barr virus associated gastric cancer in histology

Yeojin Jeong
Cristina Eunbee Cho
Sangjeong Ahn
ResearchOpen Access02 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Intermolecular steric inhibition of Ephexin4 is relieved by Elmo1

Kwanhyeong Kim
Juyeon Lee
Daeho Park
ResearchOpen Access30 Jun 2017
Scientific Reports

Volume: 7, P: 1-10
Functional and evolutionary analysis of Korean bob-tailed native dog using whole-genome sequencing data

Daehwan Lee
Dajeong Lim
Jaebum Kim
ResearchOpen Access11 Dec 2017
Scientific Reports

Volume: 7, P: 1-8
Soluble RAGE attenuates AngII-induced endothelial hyperpermeability by disrupting HMGB1-mediated crosstalk between AT1R and RAGE

Jisu Jeong
Jiye Lee
Sungha Park
ResearchOpen Access27 Sept 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-15
Toward a unified framework for interpreting machine-learning models in neuroimaging

Neuroimaging-based machine-learning models should be interpretable to neuroscientists and users in applied settings. This protocol describes how to assess the interpretability of models based on fMRI.

Lada Kohoutová
Juyeon Heo
Choong-Wan Woo
Protocols18 Mar 2020
Nature Protocols

Volume: 15, P: 1399-1435
Chiral Separation by Flows: The Role of Flow Symmetry and Dimensionality

Sunghan Ro
Juyeon Yi
Yong Woon Kim
ResearchOpen Access14 Oct 2016
Scientific Reports

Volume: 6, P: 1-10
MicroRNA-7-5p mediates the signaling of hepatocyte growth factor to suppress oncogenes in the MCF-10A mammary epithelial cell

Dawoon Jeong
Juyeon Ham
Sun Jung Kim
ResearchOpen Access13 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Automatic segmentation of inconstant fractured fragments for tibia/fibula from CT images using deep learning

Hyeonjoo Kim
Young Dae Jeon
Do-Kun Yoon
ResearchOpen Access22 Nov 2023
Scientific Reports

Volume: 13, P: 1-12
SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion

Sunho An
Tam Thuy Lu Vo
Ji Hae Seo
ResearchOpen Access03 Apr 2023
Experimental & Molecular Medicine

Volume: 55, P: 779-793
Internalization of apoptotic cells during efferocytosis requires Mertk-mediated calcium influx

Susumin Yang
Chanhyuk Min
Daeho Park
ResearchOpen Access30 Jun 2023
Cell Death & Disease

Volume: 14, P: 1-11
Frequent patient retraining at home reduces the risks of peritoneal dialysis-related infections: A randomised study

Jae Hyun Chang
Jieun Oh
Kook-Hwan Oh
ResearchOpen Access27 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
A chimeric antibody to L1 cell adhesion molecule shows therapeutic effect in an intrahepatic cholangiocarcinoma model

Eung Suk Lee
Mun Sik Jeong
Hyo Jeong Hong
ResearchOpen Access17 Jan 2012
Experimental & Molecular Medicine

Volume: 44, P: 293-302
After cell death: the molecular machinery of efferocytosis

Byeongjin Moon
Susumin Yang
Daeho Park
ReviewsOpen Access23 Aug 2023
Experimental & Molecular Medicine

Volume: 55, P: 1644-1651
A chromosome-level genome assembly of the Korean crossbred pig Nanchukmacdon (Sus scrofa)

Daehong Kwon
Nayoung Park
Jaebum Kim
ResearchOpen Access03 Nov 2023
Scientific Data

Volume: 10, P: 1-11
Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization

Juyeon Jo
Seol Hee Im
Michael J Galko
ResearchOpen Access11 May 2017
Cell Death & Disease

Volume: 8, P: e2786
A novel HSP90 inhibitor SL-145 suppresses metastatic triple-negative breast cancer without triggering the heat shock response

Ji Young Kim
Tae-Min Cho
Jae Hong Seo
ResearchOpen Access02 May 2022
Oncogene

Volume: 41, P: 3289-3297

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