The authors profiled differentially expressed microRNAs between parental adherent breast cancer cells and breast cancer stem cell (BCSC) -mimicking mammospheres, and identified hsa-miR-27a as a negative regulator for survival and chemoresistance of BCSCs by downregulating genes essential for detoxification of ROS and impairing of autophagy. Enhancement of the hsa-miR-27a signaling pathway may be a potential therapeutic modality for breast cancer.
- Shinobu Ueda
- Masakatsu Takanashi
- Masahiko Kuroda
