The molecular mechanisms underlying thrombosis in acute myeloid leukemia (AML), which contribute to poor clinical outcomes, remain to be explored. Here, the authors show that hexokinase 2 (HK2)-mediated glycolysis leads to lactate-driven histone lactylation, inducing thrombosis in AML.
- Qin Bai
- Yu-Xiang Qiu
- Xiao-Zhong Wang
