The tumour suppressor p53 can mediate both cell-cycle arrest and apoptosis. Apak binds and acetylates p53 by recruiting KAP-1 and HDAC1 to specifically suppress p53 regulated pro-apoptotic genes. Stress-induced phosphorylation of Apak by ATM relieves this inhibition.
- Chunyan Tian
- Guichun Xing
- Fuchu He
