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Showing 1–38 of 38 results
Advanced filters: Author: Kelly Rae Chi Clear advanced filters

  • Single-cell genome and transcriptome sequencing methods are generating a fresh wave of biological insights into development, cancer and neuroscience. Kelly Rae Chi reports.

    • Kelly Rae Chi
    News
    Nature Methods
    Volume: 11, P: 13-17

  • After a long period of measured development and a recent surge of technical advances driven by physicists, super-resolution fluorescence microscopy emerged in 2008 as a powerful tool for biologists. Kelly Rae Chi reports.

    • Kelly Rae Chi
    News
    Nature Methods
    Volume: 6, P: 15-18

  • Rapid technological developments have spurred big changes in the requisite genome-sequencing jobs. Kelly Rae Chi assesses the sequencing assembly line.

    • Kelly Rae Chi
    Comments & Opinion
    Nature
    Volume: 465, P: 256-257

  • Project management requires a subtle set of skills that many researchers find hard to master. Kelly Rae Chi provides a guide.

    • Kelly Rae Chi
    Comments & Opinion
    Nature
    Volume: 467, P: 240-241

  • In 2007, the next-generation sequencing technologies have come into their own with an impressive array of successful applications. Kelly Rae Chi reports.

    • Kelly Rae Chi
    News
    Nature Methods
    Volume: 5, P: 11-14

  • Genome-wide association studies have identified hundreds of genetic clues to disease. Kelly Rae Chi looks at three to see just how on-target the approach seems to be.

    • Kelly Rae Chi
    News
    Nature
    Volume: 461, P: 712-714

  • Applying systems biology to cancer research has become a growth area for computationally minded scientists. Kelly Rae Chi tallies the possibilities.

    • Kelly Rae Chi
    Comments & Opinion
    Nature
    Volume: 464, P: 1090-1091

  • Overcoming the limitations of spatial and temporal resolution to image within a cell is no easy feat. Kelly Rae Chi examines the latest diffraction-busting technologies.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 462, P: 676-678

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

    • George Crowley
    • Robert C. Jones
    • Stephen R. Quake
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Little is known about the function of most long non-coding RNAs. But a suite of new tools might change that.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 529, P: 423-425

  • Inflammatory bowel disease is a growing problem in Asia. But that increase presents a golden opportunity for research.

    • Kelly Rae Chi
    Comments & Opinion
    Nature
    Volume: 540, P: S100-S102

  • Research-tool developers must be creative, innovative and willing to collaborate with people from a variety of fields.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 497, P: 653-655

  • Scientists are uncovering the hidden switches in our genome that dial gene expression up and down, but much work lies ahead to peel back the many layers of regulation.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 538, P: 275-277

  • Before data were so abundant, computer models of the brain were simple. Information is now much more plentiful — but some argue that models should remain uncomplicated.

    • Kelly Rae Chi
    Comments & Opinion
    Nature
    Volume: 531, P: S16-S17

  • Historically, women have been the focus of body-image studies. But as men pay more attention to their appearance, researchers are forming a clearer picture of male self-image.

    • Kelly Rae Chi
    Comments & Opinion
    Nature
    Volume: 526, P: S12-S13

  • Cancer vaccines have long shown lots of potential but few results. Signs of success now suggest opportunities.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 471, P: 537-538

  • Problems with the lysosome cause more than just lysosomal storage disorders. This crucial cellular component has a surprising role in several common and complex conditions.

    • Kelly Rae Chi
    Comments & Opinion
    Nature
    Volume: 537, P: S148-S150

  • As researchers open up to the reality of RNA modification, an expanded epitranscriptomics toolbox takes shape.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 542, P: 503-506

  • Birthweight has been found to associate with later-life health outcomes. Here the authors perform a meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, identifying differentially methylated CpGs in neonatal blood that associate with birthweight.

    • Leanne K. Küpers
    • Claire Monnereau
    • Janine F. Felix
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Liquid biopsies can detect cancer signs from a blood sample, without the need for invasive procedures. But further work is needed before they can become reliable diagnostic tools.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 532, P: 269-271

  • In designing microscopy software to take advantage of better hardware, developers are facing challenges of accessibility, functionality and usability.

    • Kelly Rae Chi
    Special Features
    Nature Methods
    Volume: 5, P: 651-658

  • Beginners hoping to initiate and complete a clinical trial must understand the complexities of the process.

    • Kelly Rae Chi
    Special Features
    Nature
    Volume: 493, P: 565-567

  • Stem cell technology and computational modelling offer the promise of reducing the current burden of cardiotoxicity assessment.

    • Kelly Rae Chi
    News
    Nature Reviews Drug Discovery
    Volume: 12, P: 565-567

  • Intercept Pharmaceuticals has announced plans for the first ever pivotal trial in non-alcoholic steatohepatitis (NASH), setting a high bar for a growing pipeline of drugs against the liver disease.

    • Kelly Rae Chi
    News
    Nature Reviews Drug Discovery
    Volume: 14, P: 447-448

  • The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

    • Marie-Christine Birling
    • Atsushi Yoshiki
    • Stephen A. Murray
    Comments & Opinion
    Nature Genetics
    Volume: 53, P: 416-419

  • Tuberculous menigitis (TBM) presents a major health burden around the world, especially in individuals with concomitant HIV infection, in whom mortality is nearly 50%. Here, members of the TBM International Research Consortium summarize our current understanding of TBM pathogenesis, diagnosis and management, and discuss key avenues for future research.

    • Robert J. Wilkinson
    • Ursula Rohlwink
    • Guy E. Thwaites
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 581-598