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Showing 1–50 of 66 results

Advanced filters: Author: Kensuke Yoshida Clear advanced filters

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
CT-based phenotyping of COVID-19: cluster analysis of pulmonary and extrapulmonary imaging markers from a multicentre retrospective cohort study

Shiro Otake
Naoya Tanabe
Koichi Fukunaga
ResearchOpen Access26 Nov 2025
Scientific Reports

Volume: 15, P: 1-13
Reversible Formation of Interpenetrating Polymer Network Structure in Organic-Inorganic Polymer Hybrids

Yusuke Imai
Kensuke Naka
Yoshiki Chujo
Research01 Dec 1998
Polymer Journal

Volume: 30, P: 990-995
Thermoresponsive Organic–Inorganic Polymer Hybrids from Poly(N-isopropylacrylamide)

Yusuke Imai
Naoki Yoshida
Yoshiki Chujo
Research01 Mar 1999
Polymer Journal

Volume: 31, P: 258-262
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Synthesis and Optical Properties of Soluble Isoxazole-Containing Poly(p-phenylene)-Related Polymer

Kensuke Naka
Etsuo Horii
Yoshiki Chujo
Research01 Jan 2000
Polymer Journal

Volume: 32, P: 73-74
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Preparation of Soluble Poly(azomethine)s Having the β-Diketonate Metal Complex in the Main Chain

Kensuke Naka
Etsuo Horii
Yoshiki Chujo
Research01 Apr 2000
Polymer Journal

Volume: 32, P: 316-320
Novel Aprotic Polar Polymers IV. Synthesis of Poly[N-bis(dimethylamino)phosphorylethylenimine] as a Polymer Homolog of Hexamethylphosphoramide

Toshiyuki Oyama
Yasushi Ohkubo
Yoshiki Chujo
Research01 Dec 1998
Polymer Journal

Volume: 30, P: 1008-1010
Linearly Extended π-Conjugated Dithiafulvene Polymer Formed Soluble Charge-Transfer Complex with 7,7,8,8-Tetracyanoquinodimethane

Kensuke Naka
Takashi Uemura
Yoshiki Chujo
Research01 May 2000
Polymer Journal

Volume: 32, P: 435-439
Synthesis and Characterization of New Side-Chain Liquid Crystalline Polyoxazolines

Kyung-Min Kim
Yusuke Imai
Yoshiki Chujo
Research01 Aug 2000
Polymer Journal

Volume: 32, P: 657-664
Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model

Here, the authors develop a PMO-based heteroduplex oligonucleotide technology that enhances PMO delivery to tissues and normalizes motor/cardiac function and CNS symptoms in a mouse model of Duchenne muscular dystrophy.

Juri Hasegawa
Tetsuya Nagata
Takanori Yokota
ResearchOpen Access26 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Synthesis of Poly(N,N-dimethylacrylamide)/Silica Gel Polymer Hybrids by in situ Polymerization Method

Ryo Tamaki
Kensuke Naka
Yoshiki Chujo
Research01 Jan 1998
Polymer Journal

Volume: 30, P: 60-65
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Adsorption of Enzymes at Silica-Gel with Amphiphilic Block Copolymers

Kensuke Naka
Kaoru Iwaki
Shigeru Maeda
Research01 Oct 1996
Polymer Journal

Volume: 28, P: 911-915
Synthesis of Poly(cyclodiborazane)s by Hydroboration Polymerization Using Mesitylborane

Noriyoshi Matsumi
Kensuke Naka
Yoshiki Chujo
Research01 Oct 1998
Polymer Journal

Volume: 30, P: 833-837
Novel Aprotic Polar Polymers V. Synthesis of Poly(HMPA) by Ring-Opening Polymerization

Toshiyuki Oyama
Yasushi Ohkubo
Yoshiki Chujo
Research01 Jun 1999
Polymer Journal

Volume: 31, P: 506-509
Introduction of Ag and Ag₂S Nanoparticles into Nylon 6 Film and Fiber

Yasuo Gotoh
Takashi Kanno
Shigehito Deki
Research01 Dec 2003
Polymer Journal

Volume: 35, P: 960-964
Gas Permeation Properties of Conducting Polymer/Porous Media Composite Membranes II

Kensuke Kamada
Jun Kamo
Hiroshi Hosokawa
Research01 Jul 1994
Polymer Journal

Volume: 26, P: 833-839
Development and validation of predictive model for emesis in cervical cancer patients receiving concurrent chemoradiotherapy based on multi-institutional retrospective study

Kensuke Yoshida
Hajime Morita
Munetoshi Sugiura
ResearchOpen Access27 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Chiral symmetry restoration at high matter density observed in pionic atoms

In quantum chromodynamics, the condensation of quark–antiquark pairs breaks the chiral symmetry of vacuum. Experiments with pionic tin atoms demonstrate that the symmetry is partially restored at high densities.

Takahiro Nishi
Kenta Itahashi
Koichi Yoshida
Research23 Mar 2023
Nature Physics

Volume: 19, P: 788-793
DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo

Using gene silencing to regulate lymphocyte function is a promising therapeutic approach for autommunity, inflammation and cancer. Here the authors use a heteroduplex oligonucleotide for improved potency, efficacy and longer retention times.

Masaki Ohyagi
Tetsuya Nagata
Takanori Yokota
ResearchOpen Access22 Dec 2021
Nature Communications

Volume: 12, P: 1-12
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS

Genes in the rodent brain are knocked down by DNA/RNA heteroduplexes injected intravenously.

Tetsuya Nagata
Chrissa A. Dwyer
Takanori Yokota
Research12 Aug 2021
Nature Biotechnology

Volume: 39, P: 1529-1536
Butterfly-shaped magnetoresistance in triangular-lattice antiferromagnet Ag₂CrO₂

Hiroki Taniguchi
Mori Watanabe
Yasuhiro Niimi
ResearchOpen Access13 Feb 2020
Scientific Reports

Volume: 10, P: 1-7
Increased blood pressure variability during the subacute phase of ischemic stroke is associated with poor functional outcomes at 3 months

Hiroyuki Naito
Naohisa Hosomi
Hirofumi Maruyama
ResearchOpen Access21 Jan 2020
Scientific Reports

Volume: 10, P: 1-7
A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer

Advanced colorectal cancers are characterised by intra-tumour heterogeneity dictated by neutral evolution. Here the authors analyse early colorectal tumours by whole-exome sequencing and find that Darwinian evolution determines the fate of early lesions in colorectal adenoma and carcinoma in situ.

Tomoko Saito
Atsushi Niida
Koshi Mimori
ResearchOpen Access23 Jul 2018
Nature Communications

Volume: 9, P: 1-11
Proliferating coacervate droplets as the missing link between chemistry and biology in the origins of life

Coacervate droplets (CDs) are a model for protocells formed by liquid-liquid phase separation (LLPS), but protocell models able to proliferate remain undeveloped. Here, the authors report a proliferating peptide-based CD using synthesised amino acid thioesters as monomers, which could concentrate RNA and lipids, enabling RNA to protect the droplet from dissolution by lipids.

Muneyuki Matsuo
Kensuke Kurihara
ResearchOpen Access24 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Synthesis of Electron-Donating Polymer Having Vinylogous TTF in the Main Chain

Shinsuke Inagi
Kensuke Naka
Yoshiki Chujo
Reviews04 Oct 2006
Polymer Journal

Volume: 38, P: 1146-1151
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Autoimmune pancreatitis and IgG4-related sclerosing disease

Autoimmune pancreatitis (AIP) is a unique form of pancreatitis that is suspected to involve autoimmune mechanisms. Given that AIP responds dramatically to steroid therapy, it is important to distinguish it from pancreatic cancer. AIP may be one manifestation of IgG4-related sclerosing disease, which is a systemic disease in which IgG4-positive plasma cells and T lymphocytes extensively infiltrate various organs. Kamisawa and colleagues describe the clinical and pathophysiological features of AIP and IgG4-related sclerosing disease.

Terumi Kamisawa
Kensuke Takuma
Tsuneo Sasaki
Reviews15 Jun 2010
Nature Reviews Gastroenterology & Hepatology

Volume: 7, P: 401-409
Author Correction: Shotgun crystal structure prediction using machine-learned formation energies

Chang Liu
Hiromasa Tamaki
Ryo Yoshida
Amendments and CorrectionsOpen Access20 Jun 2025
npj Computational Materials

Volume: 11, P: 1
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Postnatal Blocking of Interferon-γ Function Prevented Atherosclerotic Plaque Formation in Apolipoprotein E–Knockout Mice

Mitsuhisa Koga
Hisashi Kai
Tsutomu Imaizumi
Research01 Mar 2007
Hypertension Research

Volume: 30, P: 259-267
Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10)

Rurika Okuda
Yotaro Ochi
Seishi Ogawa
ResearchOpen Access23 Dec 2024
Leukemia

Volume: 39, P: 760-764
Prevalence of erectile dysfunction as long-COVID symptom in hospitalized Japanese patients

Hideaki Kato
Nao Ichihara
Hayato Taniguchi
ResearchOpen Access21 Feb 2025
Scientific Reports

Volume: 15, P: 1-7
A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling

Abe et al. profile, characterize and compare non-haematopoietic cells in normal human lymph nodes versus nodal lymphomas from patients, providing insights into stromal modelling in health and disease.

Yoshiaki Abe
Mamiko Sakata-Yanagimoto
Shigeru Chiba
ResearchOpen Access24 Mar 2022
Nature Cell Biology

Volume: 24, P: 565-578
Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion

Ryo Tomita
Takeshi Iwase
Hiroko Terasaki
ResearchOpen Access08 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Shotgun crystal structure prediction using machine-learned formation energies

Chang Liu
Hiromasa Tamaki
Ryo Yoshida
ResearchOpen Access20 Dec 2024
npj Computational Materials

Volume: 10, P: 1-14
Collagen-Binding Hepatocyte Growth Factor (HGF) alone or with a Gelatin- furfurylamine Hydrogel Enhances Functional Recovery in Mice after Spinal Cord Injury

Kentaro Yamane
Tetsuro Mazaki
Akihiro Matsukawa
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment

Tatsuya Maruhashi
Yoshihiko Kinoshita
Yukihito Higashi
Research07 Mar 2019
Hypertension Research

Volume: 42, P: 1175-1185
Escape hematopoiesis by donor-derived 6pLOH(+) hematopoietic stem cells in a marrow transplant recipient with late graft failure

Toshiya Hino
Tatsuya Imi
Kensuke Usuki
Correspondence10 Jan 2019
Bone Marrow Transplantation

Volume: 54, P: 1129-1132
First evidence for the existence of pennate diatom viruses

Yuji Tomaru
Kensuke Toyoda
Keizo Nagasaki
Research12 Jan 2012
The ISME Journal

Volume: 6, P: 1445-1448
Author Correction: Butterfly-shaped magnetoresistance in triangular-lattice antiferromagnet Ag₂CrO₂

Hiroki Taniguchi
Mori Watanabe
Yasuhiro Niimi
Amendments and CorrectionsOpen Access18 Mar 2020
Scientific Reports

Volume: 10, P: 1
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans

Jean-Michel Fustin
Shiqi Ye
Hitoshi Okamura
Amendments and CorrectionsOpen Access04 Jun 2020
Communications Biology

Volume: 3, P: 1
Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine

Eizoh Gondoh
Yusuke Hamada
Minoru Narita
Research09 Aug 2022
British Journal of Cancer

Volume: 127, P: 1565-1574
Intratumour Fusobacterium nucleatum and immune response to oesophageal cancer

Keisuke Kosumi
Yoshifumi Baba
Hideo Baba
Research04 Jan 2023
British Journal of Cancer

Volume: 128, P: 1155-1165
E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis

The authors show that the transcription factor E4BP4 mediates the production of anti-inflammatory components that reduce the magnitude of intestinal inflammation in mice.

Yasuko Kajimura
Akihiko Taguchi
Yasuharu Ohta
ResearchOpen Access07 May 2024
Communications Biology

Volume: 7, P: 1-13

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