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Showing 1–6 of 6 results
Advanced filters: Author: Kevin Meli Clear advanced filters

  • Fischer carbenes are typically synthesized by addition of pyrophoric reagents to toxic metal carbonyls. Now access to α-siloxycarbenes from thioesters has been reported via reductive silylation of cobalt acyls, providing a platform to harness carbene reactivity from carboxylates via metal acyls and allowing several new reactions occur, including heterodimerization to acyloin-type products.

    • Lingran Kong
    • Kevin Zong
    • Ryan Shenvi
    Research
    Nature Chemistry
    P: 1-8

  • A comparison of the repertoire of SARS-CoV-2-specific epitopes targeted by T cells induced by vaccination or natural infection reveals that T cells predominantly target non-spike epitopes in convalescent individuals, while there is a broader spike-specific CD8+ T-cell response in vaccinees. Despite differences in T-cell response, the targeted T-cell epitopes were conserved between the wild-type and Omicron variants in both groups.

    • Julia Lang-Meli
    • Hendrik Luxenburger
    • Christoph Neumann-Haefelin
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 675-679

  • Despite often being poorly immunogenic, some subsets of patients with hormone receptor-positive, HER2-negative (HR + /HER2-) breast cancer benefit from immunotherapy. Here, the authors present a randomised pilot clinical trial comparing a neoadjuvant run-in of either nab-paclitaxel or pembrolizumab (anti-PD-1) monotherapy, followed by the combination, in patients with stage II-III HR + /HER2- breast cancer.

    • Adrienne G. Waks
    • Jingxin Fu
    • Sara M. Tolaney
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Vaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 memory T cell pool, thereby permitting reactivation of spike-specific CD8 + T cells upon breakthrough infection or 4th vaccination.

    • Matthias Reinscheid
    • Hendrik Luxenburger
    • Maike Hofmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Longitudinal analyses of SARS-CoV-2 mRNA vaccine-elicited epitope-specific CD8+ T cell responses shows that CD8+ T cells are rapidly induced after prime vaccination and stably maintained after boost vaccination.

    • Valerie Oberhardt
    • Hendrik Luxenburger
    • Maike Hofmann
    ResearchOpen Access
    Nature
    Volume: 597, P: 268-273

  • A technique using barcoded beads for DNA sequencing within tissue sections enables spatial resolution of tumour clonal heterogeneity and can be multiplexed with other analytical techniques for analysis of complex cellular phenotypes.

    • Tongtong Zhao
    • Zachary D. Chiang
    • Fei Chen
    Research
    Nature
    Volume: 601, P: 85-91