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Memory-centric computing refers to computing designs where the memory, rather than the processor is central in the architecture. Here, the authors demonstrate a self-rectifying resistive memory cell that exhibits impressive endurance, and low power consumption, making it suitable for memory-centric applications.

The research to utilize chemical potential mismatch for materials synthesis has been limited across the oxide interface. Here, the authors show that directional ionic transport from the VO₂ layers stabilizes the rutile TiO₂ phase at extremely low temperatures, at which epitaxy is difficult, by effectively lowering the activation barrier for crystallization.

Unrestricted integration of single-crystal oxide films on Si substrates allows for exploitation of emerging functionality of new materials in mature silicon devices. Here the authors integrate epitaxial oxide films with sharp metal-insulator transition on Si substrates by epitaxial lift-off of a freestanding nanomembrane.

Adipose CoA handling is critical for lipid metabolism and homeostasis. Here, the authors identify TMEM120A as an ER-resident CoA binding protein enriched in adipocytes that promotes fatty acid recycling to support energy metabolism and limit lipotoxic stress, while its loss leads to adipose inflammation and metabolic dysfunction under high-fat diet conditions.

People can easily extract task-relevant gist features from visual scenes and hold those features in working memory. Here, the authors show that this gist information is gradually abstracted from posterior to anterior regions of the brain and stably represented at the anterior region.

It is shown that vanadium dioxide thin films can reversibly accommodate hydrogen within their lattice structures, while demonstrating an insulator–metal–insulator phase modulation with hydrogen doping.

Mast cells play a key role in obesity and insulin resistance through incompletely understood mechanisms. Here the authors report that loss of sirtuin 6 in mast cells promotes inflammation, fibrosis, and metabolic dysfunction in obesity via galectin-3 in mice.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Iron-based superconductors exhibit complex couplings between different electronic degrees of freedom, leading to unusual correlated phases. Ok et al. show that Sr₂VO₃FeAs develops a hidden order state due to frustrated interactions between the magnetic fluctuations of its SrVO₃ and SrFeAs layers.

In proliferative retinopathies, pathological vessels replace healthy ones, impairing vision. Here, the authors show that reprogramming the metabolic environment of retinal blood vessels from fatty acid oxidation to glycolysis promotes healthy revascularization and improves vision in proliferative retinopathy.

The insulator-to-metal transition in vanadium dioxide still has many unexplored properties. Here the authors use multi-modal THz and mid-IR nano-imaging to examine the phase transition in VO₂ thin films, and discuss the unexpectedly smooth transition at THz frequencies in the context of a dimer Hubbard model.

This study shows that long-term exercise improves brain waste clearance by enhancing glymphatic influx and mLV flow through neuroinflammation reduction, highlighting exercise as a promising non-drug strategy to prevent neurodegenerative diseases.

The conventional solid-state reaction suffers from the low diffusivity, high energy consumption, and uncontrolled morphology. Here, the authors report a low-temperature solid-state reaction under water vapour for synthesis of various electrodes for lithium ions batteries.

The intermediate states in photo-excited phase transitions are expected to be inhomogeneous. However, ultrafast X-ray imaging shows the early part of the metal–insulator transition in VO₂ is homogeneous but then becomes heterogeneous.

Aqueous zinc ion batteries are good systems for large-scale energy storage. Here, the authors report that the corrosion of zinc metal anode is the origin of limited lifetime of vanadium oxide-based aqueous zinc ion batteries, and supressing corrosion improves the calendar and cycle lifetime markedly.

Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.

This study reveals that SHANK3 deficiency in brain endothelial cells disrupts BBB function during the neonatal period through β-Catenin imbalance, leading to ASD-related neuronal and behavioral abnormalities.

Controlling phase transitions in solids is crucial for many applications. Ultrafast laser pulses have now been shown to enable the energy-efficient generation of structural fluctuations in VO₂ by harnessing the correlated disorder in the material.

Sodium-ion batteries are promising low-cost alternatives to lithium-ion systems yet limited by underperforming anodes. This Review highlights advances and challenges in hard carbon and alloy-based anodes, outlining design strategies to boost capacity, stability and commercial viability of next-generation high-energy sodium-ion batteries.

A general synthetic solution toward high-oxidation state securinega alkaloids could be useful for systematic biological studies. Here, the authors report a divergent synthesis of C4-oxygenated securinega alkaloids via stereocontrolled diversifications on the piperidine core.

An atomic stencilling method based on the co-adsorption of iodide and 2-naphthalenethiol on gold is described, yielding more than 20 different types of nanoparticle with masked and painted regions and patchy particle morphologies not reported previously.

No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice.

In this work, Beyer and colleagues have utilized display screening technologies to comprehensively chart RAS proteins “druggability” and in doing so unravel a targetable ligand-induced pocket in RAS opening unprecedented anti-RAS targeted opportunities.

Electrochromic materials reversibly change their colour upon application of an electric field. Seidelet al. measure the optical properties of doped bismuth ferrite and report the largest electrochromic response for an inorganic material, which they attribute to the melting of oxygen-vacancy ordering.

The mechanisms for disease progression in alcohol-related steatohepatitis are incompletely understood. Here the authors report that binge drinking on top of chronic alcohol consumption in mice triggers the release of glutamate by hepatocytes, leading to liver inflammation via mGluR5/NOX2 -mediated reactive oxygen species production in Kupffer cells.

Cryo-EM visualization of the bacterial pore-forming toxin VopQ bound to its host V-ATPase membrane-domain target reveals how cytotoxic effector proteins promote membrane disruption and inhibit ATPase function.

The mammalian circadian clock is composed of clock genes forming transcriptional feedback loops. Here, the authors identify a key role of the secondary feedback loop that is interlocked with the core loop to establish a perturbation-resilient clock system.

Regular physical activity reduces the risk of chronic disease and mortality, but the mechanisms underpinning this protective effect are poorly understood. Here, Kim et al. review candidate genes and pathways implicated in human performance by genetic, genomic and multi-omic studies.

Mitochondrial biogenesis is stimulated to meet energy requirements in response to extracellular signals including exercise. TAZ is revealed as a novel stimulator for mitochondrial biogenesis and facilitates exercise-induced muscle adaptation.

Brown adipose tissue (BAT) is a specialized thermogenic organ that undergoes high demands of protein synthesis during thermogenic adaptation. Here, the authors show that the cold responsive phosphatase Ssu72 is required for mRNA translation that affects thermogenic adaptation in BAT.

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial role for it in maintaining brown adipocyte mitochondrial OXPHOS and thermogenesis upon cold stimulus.

A newly identified exercise-induced signalling metabolite—an amidated conjugate of lactate and phenylalanine—can reduce food intake and improve blood glucose homeostasis.

Direct methane protonic ceramic fuel cells are promising electrochemical energy conversion devices. However, their performance and stability remain challenging. Here, the authors develop a self-assembled Ni-Rh bimetallic catalyst which shows great enhancements in power output and long-term operational sustainability.