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Showing 1–50 of 52 results

Advanced filters: Author: Koichi Iwata Clear advanced filters

Haloaldehyde Polymers LXII. High Resolution Solid State ¹³C NMR Spectra of Chloral and Bromal Polymers

Koichi Hatada
Koichi Ute
Otto Vogl
Research01 Mar 1994
Polymer Journal

Volume: 26, P: 267-271
Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Understanding the genomic features of dedifferentiated liposarcoma (DDLPS) is likely to uncover new options for management. Here, the authors reveal three prognostic groups, and highlight molecular markers associated with malignant transformation.

Makoto Hirata
Naofumi Asano
Koichi Matsuda
ResearchOpen Access12 Dec 2019
Nature Communications

Volume: 10, P: 1-12
Population-specific putative causal variants shape quantitative traits

Genome-wide association and fine-mapping analyses in approximately 260,000 Japanese individuals combined with a newly constructed Japanese-specific genotype reference panel identify hundreds of new loci and putative causal variants for 63 quantitative traits.

Satoshi Koyama
Xiaoxi Liu
Chikashi Terao
ResearchOpen Access03 Oct 2024
Nature Genetics

Volume: 56, P: 2027-2035
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

In breast cancer, genome-wide associations studies (GWAS) have highlighted loci associated with disease risk. Here, the authors perform a meta-analysis of GWAS data from Asian populations, discovering 31 potential new risk loci, 10 of which are validated in an independent disease cohort.

Xiang Shu
Jirong Long
Wei Zheng
ResearchOpen Access05 Mar 2020
Nature Communications

Volume: 11, P: 1-9
Incidence and site specific characteristics of angiosarcoma in Japan using a population-based national cancer registry from 2016 to 2019

Toshiyuki Takemori
Koichi Ogura
Akira Kawai
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-9
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Structural basis for hepatitis B virus restriction by a viral receptor homologue

Here the authors look at why macaque is non-susceptible to hepatitis B virus by focusing on the protein structure of the host receptor homolog. They show that macaque-derived host receptor homolog has multiple structural defects against virus binding.

Kaho Shionoya
Jae-Hyun Park
Koichi Watashi
ResearchOpen Access25 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Structural basis of hepatitis B virus receptor binding

In this study, Asami et al. present the cryo-EM structure of the complex between hepatitis B virus protein and its host entry receptor NTCP, which provide a blueprint for the rational design of anti-HBV drugs targeting virus entry.

Jinta Asami
Jae-Hyun Park
Umeharu Ohto
Research17 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 447-454
Publisher Correction: Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Makoto Hirata
Naofumi Asano
Koichi Matsuda
Amendments and CorrectionsOpen Access19 Feb 2020
Nature Communications

Volume: 11, P: 1
Structural insights into the HBV receptor and bile acid transporter NTCP

Cryo-electron structures of the hepatitis B virus receptor NTCP show a distinct membrane topology compared with other SLC10 proteins, but a common bile acid transport mechanism that is shared with related mammalian and bacterial proteins.

Jae-Hyun Park
Masashi Iwamoto
Sam-Yong Park
ResearchOpen Access17 May 2022
Nature

Volume: 606, P: 1027-1031
The impact of landscape structure on pesticide exposure to honey bees

Pesticides must be evaluated for their exposure to honey bees across diverse landscapes. This study reveals that both agricultural lands and urban areas resulted in higher pesticide exposure of bees, whereas forests were considered pesticide mitigation areas.

Shumpei Hisamoto
Makihiko Ikegami
Yoshiko Sakamoto
ResearchOpen Access22 Oct 2024
Nature Communications

Volume: 15, P: 1-11
GML sensitizes cancer cells to Taxol by induction of apoptosis

Yasutoshi Kimura
Tomohisa Furuhata
Takashi Tokino
Research11 Sept 1997
Oncogene

Volume: 15, P: 1369-1374
Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome

Kazuchika Nishitsuji
Syunsuke Watanabe
Koichi Tsuneyama
ResearchOpen Access01 Nov 2018
Scientific Reports

Volume: 8, P: 1-10
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits

Matoba et al. performed GWAS on 13 dietary habits in Japanese individuals, identifying ten new associations in eight traits and five dietary-trait-associated loci with pleiotropic effects on multiple human disease and clinical measurements.

Nana Matoba
Masato Akiyama
Yukinori Okada
Research20 Jan 2020
Nature Human Behaviour

Volume: 4, P: 308-316
Soft chromophore featured liquid porphyrins and their utilization toward liquid electret applications

Though electret materials are attractive for realizing flexible mechanoelectrical devices, these materials are typically solid films. Here, the authors report stretchable ‘liquid-electret’ devices consisting solvent-free liquid porphyrins that show piezoelectric and electroacoustic functionality.

Avijit Ghosh
Manabu Yoshida
Takashi Nakanishi
ResearchOpen Access30 Sept 2019
Nature Communications

Volume: 10, P: 1-9
Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome

Kazuchika Nishitsuji
Jinzhong Xiao
Koichi Tsuneyama
ResearchOpen Access20 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score

Takehiko Yamanashi
Pedro S. Marra
Gen Shinozaki
ResearchOpen Access09 Jul 2021
Scientific Reports

Volume: 11, P: 1-8
Supramolecular fluorescence sensor for liquefied petroleum gas

Sensing dilute hydrocarbons such as liquefied petroleum gas presents challenges for selectivity and sensitivity. Here a cube-shaped assembly of amphiphiles selectively exhibits fluorescence in the presence of alkanes in water at room temperature, with a response time on the order of seconds.

Yi-Yang Zhan
Jingyuan Liao
Shuichi Hiraoka
ResearchOpen Access13 Sept 2019
Communications Chemistry

Volume: 2, P: 1-7
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

A genome-wide association study (GWAS) of 58 traits using data from the Biobank Japan Project identifies 1,407 loci, 679 of which are novel. Comparison with disease GWASs and analysis of genetic correlations and cell-type enrichment show that these clinical measurements are relevant to human disease.

Masahiro Kanai
Masato Akiyama
Yoichiro Kamatani
ResearchOpen Access05 Feb 2018
Nature Genetics

Volume: 50, P: 390-400
A BF subtype “Fb1” is a marker gene of some mongoloid populations

Koichi Suzuki
Shinya Mutoh
Hideo Matsumoto
Research01 Jun 1990
Japanese journal of human genetics

Volume: 35, P: 169-177
Mechanical properties of cold-drawn films of ultrahigh-molecular-weight poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Haloferax mediterranei

We investigated the biosynthesis and properties of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) produced by Haloferax mediterranei from glucose. Size-exclusion chromatography revealed that PHBV produced by H. mediterranei in flask cultures had a weight-average molecular weight of 4.7 × 10⁶ g/mol, demonstrating production of ultrahigh-molecular-weight (UHMW) PHBV. The UHMW-PHBV (7 mol% 3-hydroxyvalerate, M_w = 4.4 × 10⁶ g/mol) obtained by jar fermenter cultivation was used to produce tenfold cold-drawn films with a tensile strength of 258.7 MPa. This suggests that UHMW-PHBV has a potential for practical, strong films.

Kotaro Ino
Shun Sato
Tomotake Morita
Research25 Jun 2020
Polymer Journal

Volume: 52, P: 1299-1306
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

Yoichiro Kamatani and colleagues perform a genome-wide association study (GWAS) for body mass index using data from 173,430 Japanese individuals. They find 85 significant loci, 51 of which are novel, and use trans-ancestral meta-analysis of GWAS from European samples to identify 61 additional new loci.

Masato Akiyama
Yukinori Okada
Yoichiro Kamatani
Research11 Sept 2017
Nature Genetics

Volume: 49, P: 1458-1467
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

Qiuyin Cai and colleagues report a genome-wide association analysis for breast cancer in 22,780 cases and 24,181 controls from 14 studies as part of the Asia Breast Cancer Consortium. They identify three loci newly associated with breast cancer susceptibility.

Qiuyin Cai
Ben Zhang
Wei Zheng
Research20 Jul 2014
Nature Genetics

Volume: 46, P: 886-890
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Genome-wide analysis in 212,453 Japanese individuals identifies loci associated with 42 diseases. Comparative analysis with European populations identifies East Asian–specific associations.

Kazuyoshi Ishigaki
Masato Akiyama
Yoichiro Kamatani
Research08 Jun 2020
Nature Genetics

Volume: 52, P: 669-679
Metabolic profiling of Alzheimer's disease brains

Koichi Inoue
Haruhito Tsutsui
Toshimasa Toyo'oka
ResearchOpen Access06 Aug 2013
Scientific Reports

Volume: 3, P: 1-9
Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan

Kennosuke Tsuda
Takeo Mukai
Kayo Yoshikawa
ResearchOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

Genome-wide association analyses identify 28 new susceptibility loci for type 2 diabetes in the Japanese population. Transethnic comparisons highlight the key role of beta cell dysfunction in type 2 diabetes across different ancestry groups.

Ken Suzuki
Masato Akiyama
Takashi Kadowaki
Research04 Feb 2019
Nature Genetics

Volume: 51, P: 379-386
GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture

Matoba et al. examine genetic components of smoking behaviours in the Japanese population, identifying seven novel loci and 11 diseases that share genetic bases with smoking behaviours.

Nana Matoba
Masato Akiyama
Yoichiro Kamatani
Research25 Mar 2019
Nature Human Behaviour

Volume: 3, P: 471-477
Comparison of Renal and Vascular Protective Effects between Telmisartan and Amlodipine in Hypertensive Patients with Chronic Kidney Disease with Mild Renal Insufficiency

Tsukasa Nakamura
Teruo Inoue
Koichi Node
Research01 May 2008
Hypertension Research

Volume: 31, P: 841-850
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone

Ken-ichi Yoshida
Yoshiko Nakano
Akihiko Yoshida
Research08 Jul 2019
Modern Pathology

Volume: 32, P: 1751-1761
Phylogeographic analysis suggests two origins for the riparian azalea Rhododendron indicum (L.) Sweet

Watanabe Yoichi
Izumi Kawamata
Motomi Ito
Research26 Feb 2018
Heredity

Volume: 121, P: 594-604
Topological data analysis (TDA) enhances bispectral EEG (BSEEG) algorithm for detection of delirium

Takehiko Yamanashi
Mari Kajitani
Gen Shinozaki
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells

Ken-Ichi Suehiro
Akira Suto
Hiroshi Nakajima
Research09 Mar 2020
Cellular & Molecular Immunology

Volume: 18, P: 1729-1738
Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model

Takehiko Yamanashi
Masaaki Iwata
Koichi Kaneko
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-11
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Involvement of oxidative stress in orofacial mechanical pain hypersensitivity following neonatal maternal separation in rats

Chihiro Soma
Suzuro Hitomi
Masamichi Shinoda
ResearchOpen Access20 Dec 2023
Scientific Reports

Volume: 13, P: 1-9
Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats

Jo Otsuji
Yoshinori Hayashi
Masamichi Shinoda
ResearchOpen Access11 Nov 2022
Scientific Reports

Volume: 12, P: 1-14
Severe Fever with Thrombocytopenia Syndrome Phlebovirus causes lethal viral hemorrhagic fever in cats

Eun-sil Park
Masayuki Shimojima
Shigeru Morikawa
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-18
The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage

Norihiko Sakai
Gretchen Bain
Takashi Wada
ResearchOpen Access15 May 2019
Scientific Reports

Volume: 9, P: 1-14
Trehalose ameliorates peritoneal fibrosis by promoting Snail degradation and inhibiting mesothelial-to-mesenchymal transition in mesothelial cells

Taito Miyake
Norihiko Sakai
Takashi Wada
ResearchOpen Access31 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association

Yu Fujinami-Yokokawa
Kaoru Fujinami
Yasuhiro Murakawa
ResearchOpen Access12 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency

Lizhu Yang
Kaoru Fujinami
Yasuhiro Murakawa
ResearchOpen Access26 Mar 2020
Scientific Reports

Volume: 10, P: 1-10
Association of fronto-temporal function with cognitive ability in schizophrenia

Shenghong Pu
Kazuyuki Nakagome
Koichi Kaneko
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
A Guide to Design Functional Molecular Liquids with Tailorable Properties using Pyrene-Fluorescence as a Probe

Fengniu Lu
Tomohisa Takaya
Takashi Nakanishi
ResearchOpen Access13 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia

Shenghong Pu
Kazuyuki Nakagome
Koichi Kaneko
ResearchOpen Access01 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Associations between depressive symptoms and fronto-temporal activities during a verbal fluency task in patients with schizophrenia

Shenghong Pu
Kazuyuki Nakagome
Koichi Kaneko
ResearchOpen Access28 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

Takehiko Yamanashi
Masaaki Iwata
Koichi Kaneko
ResearchOpen Access09 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Correction: Prenatal metal concentrations and physical abnormalities in the Japan environment and children’s study

Yuichi Nakamura
Sumitaka Kobayashi
Takahiko Katoh
Amendments and Corrections08 Mar 2024
Pediatric Research

Volume: 95, P: 1659-1661

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